Protein Alignment X11L and X11Lbeta

DIOPT Version :9

• Sequence 1: NP_001285376.1
• Gene: X11L / 252671
• FlyBaseID: FBgn0026313
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_727440.3
• Gene: X11Lbeta / 31997
• FlyBaseID: FBgn0052677
• Length: 2139
• Species: Drosophila melanogaster
• Alignment Length: 1501
• Identity: 577/1501 - (38%)
• Similarity: 698/1501 - (46%)
• Gaps: 512/1501 - (34%)

  Fly    12 ESMVNPPHIQMNFGQQAQQQQSHQHQQQQQ---QQERYVWEMRTRS-----PNVTPASTVLNSPD 68
            :.:::||...........|||.:|.|||||   ||:.:...|.:.|     .|..|.|:..|:.|
  Fly   809 QRIISPPSRDPRSSSPPLQQQQYQQQQQQQLQHQQQHFASLMSSHSNNNSNTNKQPLSSDNNAED 873

  Fly    69 LNGELSYVPLQGLSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQ 133
            .:.::|.:               |:...          ...|:...:.:|.:.|.........||
  Fly   874 TSNDVSEI---------------GTISD----------LTTPEAVGLSIGIAAGEMASRASTPPQ 913

  Fly   134 GLASPGSPTDVGKADGQCLRDGEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEY 198
            ...:|  ||.|.                                ||..:
  Fly   914 TAQAP--PTAVA--------------------------------GSTAN---------------- 928

  Fly   199 EGSPRRFGSQPNTNTITMGGPRKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSG 263
                   |:.....|.|                      .|||||. :.:|.|
  Fly   929 -------GTGSGNGTAT----------------------GNATAAG-SGLGPL------------ 951

  Fly   264 TLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQPQ------------ 316
            :|..|:.||||||||||||||||||||....||:.    ..|:|.||.|...|
  Fly   952 SLHTKSSTFDYLYEFSETRKVLEEFFKCPSTDEQP----IMENGSDVDSIDIQYEFHSNFERDEE 1012

  Fly   317 -------------------------EYPATPMEQAYIGQRLARIPK-----DELYMVH----RSP 347
                                     |....|:||.......|:.|.     |...:|:    :.|
  Fly  1013 DLAEEEEAEDDEEVDDDADEENDEAEDEDEPLEQDRDQNYRAQAPPQSGHIDSERLVYSGYGQQP 1077

  Fly   348 TKKPPSDQNPSTAYQEH-------NDIELYIDSNSRSSGD-------LADTELEANLRRH----- 393
            ..:......|.:..:.|       .|.:.::||.|||||:       |...:|.:....|
  Fly  1078 QLQAQLTAQPMSGARRHYSGSPLMRDFDFFLDSTSRSSGERDADQDGLNHNQLLSTSSGHGGGVG 1142

  Fly   394 -----------SRNFTLSPETTDYDSNCGDLDSLSNDIN------CPTDFGKLYTS-MPVLEDGL 440
                       ..|:..||||||||||||||||||.::|      | :::.|.|.| ||||||||
  Fly  1143 VSGGLGVGPGGGHNYRYSPETTDYDSNCGDLDSLSGEMNGGVSTSC-SNYAKFYASAMPVLEDGL 1206

  Fly   441 SSGHASDTENNVSVVCDKQQSSQSQ----PVH-----EHNGNG--------ERLENDYNVMS--- 485
            ||||.||||||.:...:.|||:.:|    |..     ...|:|        :|:..::::.|
  Fly  1207 SSGHTSDTENNNNNQKNLQQSTVNQGGQCPTSLSGSTSIGGSGGISMLMDMKRISTNHSLNSMNN 1271

  Fly   486 -ASLATLTTDAS---------------------------QSALIS-------------------- 502
             .:.|:.|||::                           |:.|.|
  Fly  1272 QTTTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPKTLSLDQSPSNHSKVFK 1336

  Fly   503 ----DFASL---------------PMPPAPPPSSPPQI------------EIADASESMTMVPDA 536
                :..||               |.||||.|...|..            .:|..|..:.::
  Fly  1337 NIDPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGGSNDVDLL--- 1398

  Fly   537 DNPLDSHYGAVYAAALG---------GTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKE-- 590
             .|...|  ...|||:.         .|.|....|:|.|.|. :||.:..|.|...:...:.|
  Fly  1399 -QPSSKH--TPLAAAISSTLQRSSPTSTITGNGIGNGSGKTR-SAGSNCSSSANGGMPPPIPERT 1459

  Fly   591 -IRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPR------------KGTTISTAQGAAADEEPD 642
             :.||:||:.:             ..|:||||:.|            .|:...:...:|.:|:.|
  Fly  1460 NLVSAVQRSPS-------------PGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVD 1511

  Fly   643 TDLETDRLLGQQRHDEQDFFADQSLADNNANE-GTDIASNGHLNGTSDNNNPNPMNNSKPQTYST 706
            ||||||||||.||.|:|.::.:....|..... .:.|:....:..|...|..|.:.:|.|:....
  Fly  1512 TDLETDRLLGHQRLDDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPP 1576

  Fly   707 ATIR--QGIGTSLT---PNSPDICQIVG---TTDISISSPE--KLQFTKSPT------------- 748
            ...:  .|:|..||   .|...:..:||   ...:|.||.|  :...:|.|.
  Fly  1577 IPPKGQSGLGLGLTLGAGNGGKLLDLVGGMVQRSLSRSSSEHSEKSLSKMPISGGDLCAGGVDVV 1641

  Fly   749 -------------------------GSIKSLKDSAN----------------------------- 759
                                     ||.:|..:.||
  Fly  1642 ASTVAATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIGTINGGSVMPLGSGSGT 1706

  Fly   760 -------------------------------------------------SDKKA-KSRNKEGLLE 774
                                                             .:||. ||::|||
  Fly  1707 GSGAGSGAGSGTGTNAAVVANSNANNNVGGGGGGGNNSSGSGAGSNSNSGEKKVKKSKSKEG--- 1768

  Fly   775 PKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEK 839
            ..||||||||||:||||||||||||||||||||||||||||||||||:|:.||||||||||||||
  Fly  1769 GAVLIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPDGDVQPSTEVDLFISTEK 1833

  Fly   840 IMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEES 904
            ||||||||||||||||||||||||||||||||||||||||..:         .|.|.|
  Fly  1834 IMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPQDI---------DDAPKP------- 1882

  Fly   905 PPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLN 969
                     |||||||||||||||||||||||||||||||||||||||||:....||||||||||
  Fly  1883 ---------NRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIEDHRFVKEMDYQEVLN 1938

  Fly   970 SQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLN 1034
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly  1939 SQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLN 2003

  Fly  1035 IGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNG 1099
            ||||||||||:|||||||||||:||:|.||||.||||||||.|||||||.||:..:|||||||||
  Fly  2004 IGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNG 2068

  Fly  1100 VICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQ 1164
            |||||||||||||||||||||||||||||||||||:.||.||::|||||||||||||||||||||
  Fly  2069 VICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQ 2133

  Fly  1165 ETPIYI 1170
            |.||||
  Fly  2134 ENPIYI 2139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	141/178 (79%)
		PDZ_signaling	988..1065	CDD:238492	72/76 (95%)
		PDZ_signaling	1092..1151	CDD:238492	53/58 (91%)
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	142/178 (80%)
		PDZ_signaling	1957..2042	CDD:238492	79/84 (94%)
		PDZ_signaling	2047..2120	CDD:238492	62/72 (86%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3583
eggNOG	1	0.900	-	-		E1_KOG3605
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1184
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12645at7147
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm6563
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	P	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.850