Protein Alignment X11L and Apba1

DIOPT Version :10

• Sequence 1: NP_001285376.1
• Gene: X11L / 252671
• FlyBaseID: FBgn0026313
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_796008.2
• Gene: Apba1 / 319924
• MGIID: 1860297
• Length: 842
• Species: Mus musculus
• Alignment Length: 1077
• Identity: 371/1077 - (34%)
• Similarity: 496/1077 - (46%)
• Gaps: 305/1077 - (28%)

  Fly   156 EIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMI-GQLPIAEYEGSPRRFGSQPNTNTITMGGP 219
            |:.|.|:        |..|:...|.|..|:..::: ||.|   ....|...|.:|..:   .|.|
Mouse     9 EVEVADE--------APGGEVNESVEADLEHPEVVEGQQP---SPSPPPPAGHEPEDH---RGHP 59

  Fly   220 RKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRK- 283
            ...||..||.                          :.||||...|.....|....:..::|.:
Mouse    60 APPPPPPPQE--------------------------EEEEERGECLARSASTESGFHNHTDTAEG 98

  Fly   284 ----VLEEFFKA----NPEDEKRYT--------DYTTES-GDDVASSQPQEYP----------AT 321
                ...:.::|    :.:||..|.        :||.:: .:.|.::|.:..|          ..
Mouse    99 DVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALPNHLHFHSLEHEE 163

  Fly   322 PMEQAYIG----QRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLA 382
            .|..||.|    .||....:||       |..:|.:|..   ..|||...|:         ||..
Mouse   164 AMNAAYSGYVYTHRLFHRAEDE-------PYAEPYADYG---GLQEHVYEEI---------GDAP 209

  Fly   383 DTELEANLRRHS---------RNFTLSPETTDYDSNC-GDLDSLSNDINCPTDFGKLYTSMPVLE 437
            :.|....||.:.         |...|......||... |:.||...:    .:|.. |..|...|
Mouse   210 ELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKE----AEFAP-YPRMDSYE 269

  Fly   438 DGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALIS 502
                     ..|:...:|.:.:||..||.:.:
Mouse   270 ---------QEEDIDQIVAEVKQSMSSQSLDK--------------------------------- 292

  Fly   503 DFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEK-----SAG 562
                                   |:|.|   |:|:..|:.      |...||.|.:.     .||
Mouse   293 -----------------------AAEDM---PEAEQDLER------APTPGGGHPDSPGLPAPAG 325

  Fly   563 SGLGVTPVTAGGSLPSQAASE-----IQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWV 622
            ....|.. |.|||...|..|:     |..|:|:|:.|::..||:..:..:    .|.:|..|:||
Mouse   326 QQQRVVG-TPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPY----TPDEPKEPIWV 385

  Fly   623 PRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGT 687
            .|:            |..|..|.:..|.:
Mouse   386 MRQ------------DISPTRDCDDQRPV------------------------------------ 402

  Fly   688 SDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIK 752
             |.::|:| .:|.|....:::|      .|.|..|        |:.|.:...:......||
Mouse   403 -DGDSPSP-GSSSPLGAESSSI------PLHPGDP--------TEASTNKESRKSLASFPT---- 447

  Fly   753 SLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIK 817
                         .....|..:|:.||:|::|.|.|||||||:.:..|:|:.|||||:|||||||
Mouse   448 -------------YVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIK 499

  Fly   818 AL---------APEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMA 873
            ..         ||||||||.|||||||||::|.|||.|.:|.||||.|||||||||||::|||||
Mouse   500 TAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMA 564

  Fly   874 RRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQ 938
            ||| :|.|                 ..:|......|.....|..|||||||||::||.|||||||
Mouse   565 RRR-MPRS-----------------NSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQ 611

  Fly   939 AFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVV 1003
            ||.|||.|||:||||..|.|::: :|.::||:|:::.|:|..|:|.|..|:|.:.|.||||||||
Mouse   612 AFSVAYQEFLRANGINPEDLSQK-EYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVV 675

  Fly  1004 IVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAV 1068
            ||||||||:||||:|||:|..|.|.:.|:||||||:::|||.||||||||||||.|:..|||:.|
Mouse   676 IVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRV 740

  Fly  1069 KFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVP 1133
            |..:|.||||..|.|.||...:|||||||||:||||:||||||||||||||||||||.|||||.|
Mouse   741 KLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATP 805

  Fly  1134 HDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            |:.||.:||::||||.|||||.:|:||||.||.|:||
Mouse   806 HEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	107/187 (57%)
		PDZ1_APBA1_3-like	988..1071	CDD:467203	57/82 (70%)
		PDZ2_APBA1_3-like	1082..1154	CDD:467255	54/71 (76%)
Apba1	NP_796008.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		30/151 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..349		34/190 (18%)
		Mint1_CID	348..393	CDD:439308	14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	366..439		23/140 (16%)
		PTB_X11	457..628	CDD:269919	108/188 (57%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	631..648		5/17 (29%)
		PDZ1_APBA1_3-like	660..745	CDD:467203	57/84 (68%)
		PDZ2_APBA1_3-like	749..826	CDD:467255	57/76 (75%)