DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Apba1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_796008.2	Gene:	Apba1 / 319924	MGIID:	1860297	Length:	842	Species:	Mus musculus

Alignment Length:	1077	Identity:	371/1077 - (34%)
Similarity:	496/1077 - (46%)	Gaps:	305/1077 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 EIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMI-GQLPIAEYEGSPRRFGSQPNTNTITMGGP 219
            |:.|.|:        |..|:...|.|..|:..::: ||.|   ....|...|.:|..:   .|.|
Mouse     9 EVEVADE--------APGGEVNESVEADLEHPEVVEGQQP---SPSPPPPAGHEPEDH---RGHP 59

  Fly   220 RKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRK- 283
            ...||..||.                          :.||||...|.....|....:..::|.:
Mouse    60 APPPPPPPQE--------------------------EEEEERGECLARSASTESGFHNHTDTAEG 98

  Fly   284 ----VLEEFFKA----NPEDEKRYT--------DYTTES-GDDVASSQPQEYP----------AT 321
                ...:.::|    :.:||..|.        :||.:: .:.|.::|.:..|          ..
Mouse    99 DVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALPNHLHFHSLEHEE 163

  Fly   322 PMEQAYIG----QRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLA 382
            .|..||.|    .||....:||       |..:|.:|..   ..|||...|:         ||..
Mouse   164 AMNAAYSGYVYTHRLFHRAEDE-------PYAEPYADYG---GLQEHVYEEI---------GDAP 209

  Fly   383 DTELEANLRRHS---------RNFTLSPETTDYDSNC-GDLDSLSNDINCPTDFGKLYTSMPVLE 437
            :.|....||.:.         |...|......||... |:.||...:    .:|.. |..|...|
Mouse   210 ELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKE----AEFAP-YPRMDSYE 269

  Fly   438 DGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALIS 502
                     ..|:...:|.:.:||..||.:.:
Mouse   270 ---------QEEDIDQIVAEVKQSMSSQSLDK--------------------------------- 292

  Fly   503 DFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEK-----SAG 562
                                   |:|.|   |:|:..|:.      |...||.|.:.     .||
Mouse   293 -----------------------AAEDM---PEAEQDLER------APTPGGGHPDSPGLPAPAG 325

  Fly   563 SGLGVTPVTAGGSLPSQAASE-----IQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWV 622
            ....|.. |.|||...|..|:     |..|:|:|:.|::..||:..:..:    .|.:|..|:||
Mouse   326 QQQRVVG-TPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPY----TPDEPKEPIWV 385

  Fly   623 PRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGT 687
            .|:            |..|..|.:..|.:
Mouse   386 MRQ------------DISPTRDCDDQRPV------------------------------------ 402

  Fly   688 SDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIK 752
             |.::|:| .:|.|....:::|      .|.|..|        |:.|.:...:......||
Mouse   403 -DGDSPSP-GSSSPLGAESSSI------PLHPGDP--------TEASTNKESRKSLASFPT---- 447

  Fly   753 SLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIK 817
                         .....|..:|:.||:|::|.|.|||||||:.:..|:|:.|||||:|||||||
Mouse   448 -------------YVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIK 499

  Fly   818 AL---------APEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMA 873
            ..         ||||||||.|||||||||::|.|||.|.:|.||||.|||||||||||::|||||
Mouse   500 TAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMA 564

  Fly   874 RRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQ 938
            ||| :|.|                 ..:|......|.....|..|||||||||::||.|||||||
Mouse   565 RRR-MPRS-----------------NSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQ 611

  Fly   939 AFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVV 1003
            ||.|||.|||:||||..|.|::: :|.::||:|:::.|:|..|:|.|..|:|.:.|.||||||||
Mouse   612 AFSVAYQEFLRANGINPEDLSQK-EYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVV 675

  Fly  1004 IVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAV 1068
            ||||||||:||||:|||:|..|.|.:.|:||||||:::|||.||||||||||||.|:..|||:.|
Mouse   676 IVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRV 740

  Fly  1069 KFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVP 1133
            |..:|.||||..|.|.||...:|||||||||:||||:||||||||||||||||||||.|||||.|
Mouse   741 KLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATP 805

  Fly  1134 HDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            |:.||.:||::||||.|||||.:|:||||.||.|:||
Mouse   806 HEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	107/187 (57%)
		PDZ_signaling	988..1065	CDD:238492	53/76 (70%)
		PDZ_signaling	1092..1151	CDD:238492	47/58 (81%)
Apba1	NP_796008.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		30/151 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..349		34/190 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..439		23/140 (16%)
		PTB_X11	457..628	CDD:269919	108/188 (57%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	631..648		5/17 (29%)
		PDZ	661..744	CDD:366185	56/82 (68%)
		PDZ_signaling	750..823	CDD:238492	53/72 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3706
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8726
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.750