DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and Ush1c

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	140/770 - (18%)
Similarity:	243/770 - (31%)	Gaps:	236/770 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 NDYNVMSAS----LATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNP 539
            |.|::.|.:    :..:.|..:.|..:.....:|:..:|                       :.|
  Rat   138 NGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSP-----------------------EEP 179

  Fly   540 LDSHYGAVYAAALGG-----------THTEKS-----AGS-GLGVTPVTAG-------------- 573
            |...|...:.:..||           |..||.     .|| |||.: :::|
  Rat   180 LKWQYVDQFVSESGGVRGGLSSPGNRTTKEKKVFISLVGSRGLGCS-ISSGPIQKPGIFVSNVKP 243

  Fly   574 GSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPR--KGTTISTAQGAA 636
            |||.::...|..:.:.|:..           :.|.:    .|....|.|.:  :..|||...||.
  Rat   244 GSLSAEVGLETGDQIVEVNG-----------IDFTN----LDHKEAVNVLKSSRSLTISIVAGAG 293

  Fly   637 ----------ADEEPDTDLETDRLLGQQR-----------HDEQDFFADQSLADNNANEGTDIAS 680
                      .:|....:|:...||.|:|           ..|.:....:.:|...|.|......
  Rat   294 RELFMTDRERLEEARQHELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358

  Fly   681 NGHLNGTSDNNNPNPMN-----NSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEK 740
              .:...|:........     .||.|.....||...:                 ..:.:..|:.
  Rat   359 --EMEQISEEEEKFKKQWEEDWGSKEQLILPKTITAEV-----------------HPVPLRKPKS 404

  Fly   741 LQFTKSPTGSIKSLKDSANSDKKAK-------SRNKEGL-LEPKVL--IEGVLFRARYLGSTQLV 795
            ..:.....|...:::..|...||||       .:||:.| .|.|:.  .|.:|.:.:.|...:|.
  Rat   405 FGWFYRYDGKFPTIRKKAKEKKKAKYDSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLA 469

  Fly   796 CEGQPTK------------------STRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEK--- 839
            .|...|:                  .||:.|...|.:.|..:. .|...|...|...:...:
  Rat   470 QEVSETEREDLEESEKTQYWVERLCQTRLQQISSAENEITEMT-TGPPPPPPSVSPLVPPLRRFA 533

  Fly   840 --IMVLNTDLKEIMMD---HALRTISYIADIGDLVVLMARRRFVPNSVVDPSI------------ 887
              |.:..|||.:|.:|   :..:|.|.:.     |:........|:.|..|.:
  Rat   534 GGIHLHTTDLDDIPLDMFYYPPKTPSALP-----VMPHPPPSNPPSKVPAPPVLPSSDHMSSSSS 593

  Fly   888 ------TSPLGDVPTPGIGEEESPPKEPLSK-----------------HNRT------------- 916
                  ..|:...|.|.|..::..|..||..                 |..|
  Rat   594 PWVQHTPPPIPIPPPPSIPTQDLTPTRPLPSALEEVLGNHPFRTGDPGHPATDWEANTHSGKPTS 658

  Fly   917 -----------PKMICHVFESDEAQFIAQ-----SIGQAFQVAYMEFLKANGIENESLAKEMDYQ 965
                       ||..|...:......::.     .:.|.....|...:|:..:..|.|.:.:.||
  Rat   659 SPTPERSFPPAPKTFCPSPQPPRGPGVSTISKPVMVHQEHNFVYRPAVKSEVLPQEMLKRMVVYQ 723

  Fly   966 EVLNS-----QEIFGDELEIFAKKELQ-KEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSS 1024
            .....     :|.| |...:|:.:::. |:|.:.:.|.|....:.:|.|..|.:..||::.:...
  Rat   724 TAFRQDFRKYEEGF-DPYSMFSPEQIAGKDVRLLRIKKEGSLDLALEGGVDSPVGKVVVSAVYEG 787

  Fly  1025 GAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA--VKFTVVPCPP 1077
            |||.|.|.:..||:::||||..:....|:..::.::.|.||..  :...|..|||
  Rat   788 GAAERHGGVVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPP 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	42/270 (16%)
		PDZ_signaling	988..1065	CDD:238492	22/76 (29%)
		PDZ_signaling	1092..1151	CDD:238492
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492	5/26 (19%)
		PDZ_signaling	209..289	CDD:238492	20/95 (21%)
		Cgr1	<316..>358	CDD:281823	8/41 (20%)
		PDZ_signaling	751..838	CDD:238492	24/86 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900