DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Mpdz

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	1208	Identity:	233/1208 - (19%)
Similarity:	364/1208 - (30%)	Gaps:	476/1208 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DVGKADGQCLRDGEIVVFDDIDTN----------W--------MNKASSG--------QRPGSNE 181
            |:|:..|....:..::...|:|.|          |        :.|.|.|        |.|....
  Rat   652 DLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGIQAIELEKGSRGLGFSILDYQDPIDPA 716

  Fly   182 DVLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITMGGPRKRPPG----FPQRVSPTTSVANNATA 242
            :.:.|.:.:....|||.:|  |.|                  ||    |...::...|....|..
  Rat   717 NTVIVIRSLVPGGIAEKDG--RLF------------------PGDRLMFVNDINLENSTLEEAVE 761

  Fly   243 AAKASVGNLIDL-------VDHEEERSGTLREKTPTF--------------------DY-LYEFS 279
            |.|.:...::.:       :..||   |.:..|..||                    |. |.:..
  Rat   762 ALKGAPSGMVRIGVAKPLPLSPEE---GYVSAKEDTFLCSPHTCKEMGLSDKALFRADLALIDTP 823

  Fly   280 ETRKVLEEFFKA--NPEDEKRY-TDYTTESGDDVASSQPQEY----PATPMEQAYIGQRLA---R 334
            :...|.|..|::  :|:::..| |..:..|..|.|.|....|    |::|.:.......|.   .
  Rat   824 DAESVAESRFESQFSPDNDSVYSTQASVLSLHDGACSDGMNYGPSLPSSPPKDVTNSSDLVLGLH 888

  Fly   335 IPKDELY---MVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRN 396
            :..:|||   ::.|.....||:|.:|:.                 :||
  Rat   889 LSLEELYTQNLLQRQHAGSPPTDMSPAA-----------------TSG----------------- 919

  Fly   397 FTLSPETTDYDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQS 461
            ||:|    ||.    ..:::.....|........:.:|   .|||:     ||
  Rat   920 FTVS----DYT----PANAVEQKYECANTVAWTPSQLP---SGLST-----TE------------ 956

  Fly   462 SQSQPVHEHNGNGERLENDYNVMSASLATLTTD--ASQSALISDFASLPMPPAPPPSSPPQIEIA 524
                                  ::.:|..:...  ..||:|:||..|:.:......:....:.||
  Rat   957 ----------------------LAPALPAVAPKYLTEQSSLVSDAESVTLQSMSQEAFERTVTIA 999

  Fly   525 DASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMK 589
            ..|.|                      ||.|.:....|.|:.|..:..||::.......:.:.:.
  Rat  1000 KGSSS----------------------LGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCIL 1042

  Fly   590 EI-------------RSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEP 641
            .|             |:.|:|.......:||  ...|.|..:|.:|              ....|
  Rat  1043 SINEESTISLTNAQARAMLRRHSLIGPDIKF--SAAPADDRAPFYV--------------ITYVP 1091

  Fly   642 DTDLETDRL-LGQQRHD--EQDFFADQS------LADNNANEGTDIASNGHLNGTSDNNNPNPMN 697
            ...||..|: .|||...  ..|.|:..:      |.:....||.:                :.:.
  Rat  1092 AEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEE----------------SELQ 1140

  Fly   698 NSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDK 762
            |:   .||                            |.|.|.:::..:.|:   |||..|....:
  Rat  1141 NA---AYS----------------------------SWSQPRRVELWREPS---KSLGISIVGGR 1171

  Fly   763 KAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQP 827
            ...||...|.:...:.|:.||             |..|......::..:.:
  Rat  1172 GMGSRLSNGEVMRGIFIKHVL-------------EDSPAGKNGTLKPGDRI-------------- 1209

  Fly   828 STEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLG 892
             .|||           ..||::...:.|   :..|...|..||.|.:      |:|:....|||.
  Rat  1210 -VEVD-----------GMDLRDASHEQA---VEAIRKAGSPVVFMVQ------SIVNRPRKSPLP 1253

  Fly   893 DVP-------------------------TPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFI 932
            .:|                         .|...|.||......|..:.:|.:...: .||.||..
  Rat  1254 SLPHSLYPKCSFSSTNPFAESLQLTSDKAPSQSESESEKATLCSVPSSSPSVFSEM-SSDYAQPS 1317

  Fly   933 AQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKG 997
            |.::.                |:|....|..| ...|.||.:|.........||:|.
  Rat  1318 ATTVA----------------EDEDKEDEFGY-SWKNIQERYGTLTGQLHMIELEKG-------- 1357

  Fly   998 EILGVVIVESGWGSMLP--------TVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLST 1054
                    .||.|..|.        :|.|..:..:|||.|.|:|.|.|:|:.|||..|.|.....
  Rat  1358 --------HSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQN 1414

  Fly  1055 CQS------------YIRNAK--NQTAVKFTVVPCP-----PV-----------VEVKILR---- 1085
            ..|            :||||.  ||.||      ||     |:           ||..|..
  Rat  1415 ASSIIKCAPSKVKIIFIRNADAVNQMAV------CPGSAADPLPSTSESPQNKEVEPSITTSASA 1473

  Fly  1086 --------------PKALFQLGFSV-----QNGVICSLL--RGGIAERGGVRVGHRIIEINNQSV 1129
                          ||....||.::     .|||....|  |||.|:.|.::.|.||:.::::.|
  Rat  1474 VDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGAAKDGRLKPGDRILAVDDELV 1538

  Fly  1130 VAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETP 1167
            ...|   |.|.:|      |:||..|:: :|..|.|.|
  Rat  1539 AGCP---IEKFIS------LLKTAKTTV-KLTVGAENP 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	33/203 (16%)
		PDZ_signaling	988..1065	CDD:238492	26/98 (27%)
		PDZ_signaling	1092..1151	CDD:238492	20/65 (31%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	552..621	CDD:238492
		PDZ_signaling	693..776	CDD:238492	19/102 (19%)
		PDZ_signaling	993..1063	CDD:238492	15/91 (16%)
		PDZ_signaling	1150..1241	CDD:238492	25/135 (19%)
		PDZ	1348..1433	CDD:214570	25/100 (25%)
		PDZ_signaling	1482..1561	CDD:238492	26/88 (30%)
		MPDZ_u10	1563..1624	CDD:293272	2/4 (50%)
		PDZ	1625..1709	CDD:214570
		PDZ_signaling	1721..1801	CDD:238492
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900