DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and sprt

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	137/762 - (17%)
Similarity:	207/762 - (27%)	Gaps:	259/762 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLH-----QIRLGRSPGSQFETRDVLPQGLASPGS 140
            |:|.|.|.....|..|.|..:..:........|     :.|.|.|.|           |..|..|
  Fly    29 LNPKGCGSAVKYSLHSTAETNQETASTTTTSTHCSTTGRRRKGGSLG-----------GTLSSRS 82

  Fly   141 PTDVGKADGQCLRDGEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEYEGSPRRF 205
            .....|.....|:|.|.|:.:                      |::...:|:||  ...|.|...
  Fly    83 TRSESKELRSALQDREAVIQN----------------------LRIQLCLGKLP--RPTGPPLDE 123

  Fly   206 GSQP----NTNTITMGGPRKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTL- 265
            ..:|    ..|.:......||           ..:.|..:|..|..:.:.||:...:.|....|
  Fly   124 SEKPAAEQKLNRLKTEAENKR-----------IKIKNLKSALEKLDITDNIDIRIRQAELEYALG 177

  Fly   266 REKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDV------------ASSQPQEY 318
            ||:   ...|....|.|.:.....|:.||.:..|.  ...||..:            |..|..:.
  Fly   178 REE---LQMLSIVEEARALQARLEKSKPEAQTLYN--IISSGVSLSLHAVHATSGRWAVQQRTDQ 237

  Fly   319 PATPMEQA------YIGQRLARI--------PKDEL-----------YMVHRSPTKKPPSDQNPS 358
            |...:|.|      |.|.|:..|        .|:||           .:|.|..:...|..|
  Fly   238 PGFYVEWALEGDGLYKGDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQ--- 299

  Fly   359 TAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCP 423
                                   .|.|.|.|:|...|...|..:..:..:
  Fly   300 -----------------------LDQEKENNMRLQHRISYLEEQVRELQT--------------- 326

  Fly   424 TDFGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASL 488
                            :...|.|..:       .:||..|..|......|.::
  Fly   327 ----------------VKEHHPSQQQ-------QQQQQQQQNPQQNPQQNPQQ------------ 356

  Fly   489 ATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALG 553
                |.::||..::..:.     :.|||:||                 :.||....|......:|
  Fly   357 ----TSSNQSQHVTSISI-----SSPPSTPP-----------------EKPLIFQRGNYITTLVG 395

  Fly   554 GTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDS 618
            |...| ..|..:..|. |..|.:......|  ....::|..|....:.|.|.....::
  Fly   396 GKPIE-LMGDDMASTQ-TPPGHVTKTLIKE--NTHIDLRDRLSHMYSMPSKSLSASKI------- 449

  Fly   619 PVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGH 683
                     :|::..........|.:...||   |.|...:|....|..........|...|..|
  Fly   450 ---------SINSDSAYMQHHRRDKERHRDR---QHRERPRDPLQQQQQLHREHLMSTHARSVEH 502

  Fly   684 LNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPT 748
            |      |:.|.::..:.      |.||....:|....|                       |..
  Fly   503 L------NHYNGLDRRRD------TPRQSESNTLRARLP-----------------------SDM 532

  Fly   749 GSIKSLK-DSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQL 794
            .|:|||. ||.|..|.|..........||..:...|.||:.|.:.:|
  Fly   533 RSVKSLDFDSENESKPATETRTTRPTPPKKPLRLSLQRAQSLQTVEL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	7/20 (35%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900