DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Grip2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006506166.1	Gene:	Grip2 / 243547	MGIID:	2681173	Length:	1049	Species:	Mus musculus

Alignment Length:	847	Identity:	152/847 - (17%)
Similarity:	256/847 - (30%)	Gaps:	323/847 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 GQRLARIPKDELYMVHRSPTKK----------PPSDQNPSTAYQEHNDIELYIDSNSRSSGDLAD 383
            |..|.|:..||:..:.::..::          ||:.:|......:..|:.||.:.||
Mouse   113 GIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNS-------- 169

  Fly   384 TELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFG---------KLYTSMPVLEDG 439
                                                      ||         .|:.|.|::...
Mouse   170 ------------------------------------------FGFVLRGGAHEDLHKSRPLVLTY 192

  Fly   440 LSSGHASDTENNVSVVCDKQQSSQSQPVH--EHNGNGERLENDYNVMSASLATLTTDASQSALIS 502
            :..|..:|.|.::. |.|:..|....|:|  .|              :.::||| ...|..||.
Mouse   193 VRPGGPADREGSLK-VGDRLLSIDGIPLHGASH--------------ATAIATL-QQCSHEALF- 240

  Fly   503 DFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALG-----GTHTEKSAG 562
                             |:|...|:..  .|.:|..||.........:|||     |:|..|.|.
Mouse   241 -----------------QVEYDVATPD--TVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAI 286

  Fly   563 SGLGVTP---VTAGGSL-----------PSQAASEIQEAMKEIRSALQRAKTQ------------ 601
            :...:.|   |...|:|           .|.....:.||.|.:.|..::.:.:
Mouse   287 TIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPSPQSRRPLK 351

  Fly   602 -PEKLKF---------------CDEVLPTDPDSPVWV---PRKGTTISTA-----------QGAA 636
             ||.::.               |....|:...:|.|.   |.:..::|:.           ..|.
Mouse   352 PPEAVRIQRSEQLHRWDPSAPSCHSPRPSHCRAPTWAAGGPDQSRSVSSTPFSSPTMNPAFPCAN 416

  Fly   637 ADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKP 701
            |...|...:......|::|...::..:..|||.:....|..|.   |...|......:|::
Mouse   417 ASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIV---HTETTEVVLCGDPLS---- 474

  Fly   702 QTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKS 766
                      |.|..|...       :..|: ::|||..::|
Mouse   475 ----------GFGLQLQGG-------IFATE-TLSSPPLVRF----------------------- 498

  Fly   767 RNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPE-GESQPSTE 830
                  :||                      ..|.:...::|..:.|..|..:|.| |..:.:.:
Mouse   499 ------IEP----------------------DSPAERCGLLQVGDRVLAINGIATEDGTMEEANQ 535

  Fly   831 V--DLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGD 893
            :  |..::.:.::.:..|:.|          |.|...|...|.:.:||.|...:...|.:...|
Mouse   536 LLRDAALARKVVLEIEFDVAE----------SVIPSSGTFHVKLPKRRGVELGITISSASRKRG- 589

  Fly   894 VPTPGIGEEESPPKEPL--------SKHNRT------PKMIC-------HVFESDEAQFIAQSIG 937
                          |||        |..:||      .|::.       |....|..|.:.|.
Mouse   590 --------------EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEDAVQILRQC-- 638

  Fly   938 QAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGV 1002
                              |.|.|....::..||     ||.|.........|:   |..|..||:
Mouse   639 ------------------EDLVKLKIRKDEDNS-----DEQESSGAVSYTVEL---KRYGGPLGI 677

  Fly  1003 VIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA 1067
            .|  ||.......::|:.|...|.|.|.|.:::||:::|||.:||.|.|||.....::.|.....
Mouse   678 TI--SGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVT 740

  Fly  1068 VK 1069
            :|
Mouse   741 LK 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	31/202 (15%)
		PDZ_signaling	988..1065	CDD:238492	26/76 (34%)
		PDZ_signaling	1092..1151	CDD:238492
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492	5/26 (19%)
		PDZ_signaling	160..243	CDD:238492	26/166 (16%)
		PDZ_signaling	258..341	CDD:238492	18/82 (22%)
		PDZ_signaling	463..551	CDD:238492	20/160 (13%)
		PDZ_signaling	564..647	CDD:238492	20/117 (17%)
		PDZ_signaling	664..744	CDD:238492	27/84 (32%)
		PDZ_signaling	947..1026	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900