DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and GRIP1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	954	Identity:	183/954 - (19%)
Similarity:	305/954 - (31%)	Gaps:	303/954 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EFFKANPEDEKRYTDYT--TESGDDVASSQPQEYPATPMEQAYIGQRLARIPKDELYMVHRSPTK 349
            ||...:..||..||...  |:..|...:.:.|..|     :.:.|..:..:.|.|...:..:.:.
Human    86 EFLAKSNSDESPYTKSASQTKPPDGALAVRRQSIP-----EEFKGSTVVELMKKEGTTLGLTVSG 145

  Fly   350 KPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLR--RHSRNFTLSPETTDYDSNCGD 412
            ....|..|..:......|.  ..|:....||........||.  ||....:|.       .|.|:
Human   146 GIDKDGKPRVSNLRQGGIA--ARSDQLDVGDYIKAVNGINLAKFRHDEIISLL-------KNVGE 201

  Fly   413 LDSLSNDINCPTDFGKLYTSMPVLEDGLS---------------------SGHASDTENN---VS 453
            ...|..:...|          ||...|.|                     .|.|.|..|.   |.
Human   202 RVVLEVEYELP----------PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVV 256

  Fly   454 VVCDK-----QQSSQSQPVHEHNGNGERLENDYNVM------SASLATLTTDASQSALISDFASL 507
            :.|.:     .:....:|       |:||.:...:.      :.:::.|.....::||:.::...
Human   257 ITCVRPGGPADREGTIKP-------GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS 314

  Fly   508 PMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTA 572
            .|......|.|..:|:|                                  |:.|:.|||...|
Human   315 VMDSVATASGPLLVEVA----------------------------------KTPGASLGVALTT- 344

  Fly   573 GGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAA 637
                 |...::....:.:|:||  ....:...|...|.:|..|..|..:     .|::.|....|
Human   345 -----SMCCNKQVIVIDKIKSA--SIADRCGALHVGDHILSIDGTSMEY-----CTLAEATQFLA 397

  Fly   638 DEEPDTDLE-----TDRL-------LGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDN 690
            :......||     ..||       :..||.|.|..:      |:.|:..:.:.:|.|.|
Human   398 NTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQLTW------DSWASNHSSLHTNHHYN----- 451

  Fly   691 NNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKS-PTGSIKSL 754
                        ||                .||.|::...|           |.|: |..|..:|
Human   452 ------------TY----------------HPDHCRVPALT-----------FPKAPPPNSPPAL 477

  Fly   755 KDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAL 819
            ..|:.|.....:.:...      |..|.|.|:.|..|.      :.|...|.::.::..|.:
Human   478 VSSSFSPTSMSAYSLSS------LNMGTLPRSLYSTSP------RGTMMRRRLKKKDFKSSL--- 527

  Fly   820 APEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVD 884
                 |..|:.|.|     ...|::|:..|:::     |...:...|   :.:....|...::..
Human   528 -----SLASSTVGL-----AGQVVHTETTEVVL-----TADPVTGFG---IQLQGSVFATETLSS 574

  Fly   885 PSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLK 949
            |.:.|.:         |.:||.:.            |.|.:          ||.       ..:.
Human   575 PPLISYI---------EADSPAER------------CGVLQ----------IGD-------RVMA 601

  Fly   950 ANGIENESLAKEMDYQEVLNSQ-------EIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVES 1007
            .|||..|....|...|.:.:|.       ||..|..|..........|.:||.....||:.|  |
Human   602 INGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITI--S 664

  Fly  1008 GWGSMLP--TVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKF 1070
            ...|..|  .:||:::.....|.|.|.|.:||:|:||:.:.|            .|...:.||:.
Human   665 SPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRL------------DNCSMEDAVQI 717

  Fly  1071 TVVPCPPVVEVKILRPK----------ALF----------QLGFSVQNG-------VICSLLRGG 1108
             :..|..:|::||.:.:          |:.          .||.::...       :|.||.:||
Human   718 -LQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGG 781

  Fly  1109 IAER-GGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMK 1151
            :||| |.:.:|.||:.||:.|:...|....:.||..:...:.:|
Human   782 LAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLK 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	30/178 (17%)
		PDZ_signaling	988..1065	CDD:238492	22/78 (28%)
		PDZ_signaling	1092..1151	CDD:238492	20/66 (30%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	16/88 (18%)
		PDZ_signaling	227..310	CDD:238492	13/89 (15%)
		PDZ_signaling	325..408	CDD:238492	23/129 (18%)
		PDZ_signaling	545..633	CDD:238492	21/133 (16%)
		PDZ_signaling	646..730	CDD:238492	27/98 (28%)
		PDZ_signaling	746..827	CDD:238492	21/80 (26%)
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900