DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and LNX2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_699202.1	Gene:	LNX2 / 222484	HGNCID:	20421	Length:	690	Species:	Homo sapiens

Alignment Length:	230	Identity:	52/230 - (22%)
Similarity:	87/230 - (37%)	Gaps:	65/230 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   987 QKEVVVPKAKGEILGVVIVESGWGSM---LPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLV 1048
            :|.:.|.|...|.||:. |..|.||.   || :.:.::...|..||.|::..||.|:.|||:.|.
Human   466 EKHITVKKEPHESLGMT-VAGGRGSKSGELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528

  Fly  1049 GLPLSTCQSYIR-----------------------NAKNQTA--------------------VKF 1070
            .|..|...:.::                       ||:.|.:                    :..
Human   529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593

  Fly  1071 TVVPCPPVVEVKILRPKALFQLGFSVQNG----------VICSLLRGGIAERGG-VRVGHRIIEI 1124
            |:..|..:|    ||...|...|||:..|          .|.:::.|..|...| ::.|..|:.:
Human   594 TLHSCHDIV----LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAV 654

  Fly  1125 NNQSVVAVPHDTIVKLLSSSVGEILMKTM--PTSM 1157
            |..|.|.:.|..:|.:|.....::.:..:  |.|:
Human   655 NGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSL 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919
		PDZ_signaling	988..1065	CDD:238492	27/102 (26%)
		PDZ_signaling	1092..1151	CDD:238492	16/69 (23%)
LNX2	NP_699202.1	mRING-HC-C3HC3D_LNX2	45..89	CDD:319694
		modified RING-HC finger (C3HC3D-type)	50..87	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..224
		NPXY motif	208..211
		PDZ	230..316	CDD:214570
		PDZ	336..422	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..455
		PDZ_signaling	466..542	CDD:238492	25/77 (32%)
		PDZ_signaling	599..683	CDD:238492	20/87 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900