DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and Tamalin

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_620249.1	Gene:	Tamalin / 192254	RGDID:	70554	Length:	394	Species:	Rattus norvegicus

Alignment Length:	249	Identity:	54/249 - (21%)
Similarity:	88/249 - (35%)	Gaps:	53/249 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   893 DVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENES 957
            ::.|.|:...|....|.::       .:|.|.||..||....:.|..  :|.:..|...||.:..
  Rat   114 EIQTYGLHHREEQRVEMVT-------FVCRVHESSPAQLAGLTPGDT--IASVNGLNVEGIRHRE 169

  Fly   958 LAKEMDYQ-EVLNSQEIFGDEL---EIFAKKELQKEVVVPKAKGEILGVVIVESG--WGSMLPTV 1016
            :...:... .||..:.::|..:   |:.|:.:..|:.:..| .||...:::.|..  .|.::...
  Rat   170 IVDIIKASGNVLRLETLYGTSIRKAELEARLQYLKQTLYEK-WGEYRSLMVQEQRLVHGLVVKDP 233

  Fly  1017 VIANLMSS------GAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQT--AVKFT-- 1071
            .|.:.:.|      ||....|.|..|..|.|..|          .:...|.||..|  ||..|
  Rat   234 SIYDTLESVRSCLYGAGLLPGSLPFGPLLAAPGG----------ARGGSRRAKGDTDDAVYHTCF 288

  Fly  1072 -------VVPCPPVVEVKILRPKALFQLGFSVQN--GVICSLLRGGIAERGGVR 1116
                   .:|.||        |.|......|.:.  .|:|...|..::....||
  Rat   289 FGGAEPQALPPPP--------PPARAPGPGSAETPASVLCPAPRATLSRSASVR 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	14/60 (23%)
		PDZ_signaling	988..1065	CDD:238492	19/84 (23%)
		PDZ_signaling	1092..1151	CDD:238492	6/27 (22%)
Tamalin	NP_620249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		PDZ_signaling	99..184	CDD:238492	17/78 (22%)
		Interaction with PSCD3. /evidence=ECO:0000250	180..257		16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318		6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900