DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and smz-2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_491965.1	Gene:	smz-2 / 172415	WormBaseID:	WBGene00020661	Length:	274	Species:	Caenorhabditis elegans

Alignment Length:	191	Identity:	41/191 - (21%)
Similarity:	72/191 - (37%)	Gaps:	63/191 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   989 EVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLS 1053
            |:.:...:||.||....:    .::.|.:.|..:|.      |:|.||||:..:||.:     ..
Worm     8 EICIDMEEGEPLGATPND----KLVITKIQAGTISE------GKLRIGDQVKKVNGQN-----CK 57

  Fly  1054 TCQSYIRNAKNQTAVKFTVVPCP--------------------PVVEVKILRPKALF-------- 1090
            .|..:.|      |::| ..||.                    |....||::.:..:
Worm    58 DCNDFFR------ALRF-AAPCAKITVNRDEKKAEELEARVHIPEDRAKIIQRREGYVYELATLV 115

  Fly  1091 ------QLGFSV---QNGVICSLL-RGGIAERGGVRVGHRIIEINNQSV--VAVPHDTIVK 1139
                  :||..:   ||.|:.|.: .|.:||:..| :|..:.:::...|  ..|..|.:||
Worm   116 WVQNGPKLGLGIKHFQNRVLVSRVDPGSLAEKCLV-LGDHLCDVDGIPVSDKDVARDLLVK 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919
		PDZ_signaling	988..1065	CDD:238492	18/75 (24%)
		PDZ_signaling	1092..1151	CDD:238492	16/54 (30%)
smz-2	NP_491965.1	PDZ_signaling	7..77	CDD:238492	22/90 (24%)
smz-2	NP_491965.1	PDZ_signaling	114..188	CDD:238492	16/63 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900