DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Grip2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	829	Identity:	151/829 - (18%)
Similarity:	255/829 - (30%)	Gaps:	287/829 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 GQRLARIPKDELYMVHRSPTKK----------PPSDQNPSTAYQEHNDIELYIDSNSRSSGDLAD 383
            |.||.|:..||:..:.::..::          ||:.:|......:..|:.||.:.||
  Rat   106 GIRLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNS-------- 162

  Fly   384 TELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFG---------KLYTSMPVLEDG 439
                                                      ||         .|:.|.|::...
  Rat   163 ------------------------------------------FGFVLRGGAHEDLHKSRPLVLTY 185

  Fly   440 LSSGHASDTENNVSVVCDKQQSSQSQPVH--EHNGNGERLENDYNVMSASLATLTTDASQSALIS 502
            :..|..:|.|.::. |.|:..|....|:|  .|              :.::||| ...|..||.
  Rat   186 VRPGGPADREGSLK-VGDRLLSIDGIPLHGASH--------------ATAIATL-QQCSHEALF- 233

  Fly   503 DFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALG-----GTHTEKSAG 562
                             |:|...|:..  .|.:|..||.........:|||     |:|..|.|.
  Rat   234 -----------------QVEYDVATPD--TVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAI 279

  Fly   563 SGLGVTP---VTAGGSL-----------PSQAASEIQEAMKEIRSALQRAKTQ------------ 601
            :...:.|   |...|:|           .|.....:.||.|.:.|..::.:.:
  Rat   280 TIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLK 344

  Fly   602 -PEKLKF---------------CDEVLPTDPDSPVWVPR-------------KGTTISTAQGAA- 636
             ||.::.               |....|:...:|.|.|.             ...|::.|...|
  Rat   345 PPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPCAN 409

  Fly   637 ADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKP 701
            |...|...:......|::|...::..:..|||.:....|..|.   |...|......:|::
  Rat   410 ASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIV---HTETTEVVLCGDPLS---- 467

  Fly   702 QTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKS 766
                      |.|..|...       :..|: ::|||..::|
  Rat   468 ----------GFGLQLQGG-------IFATE-TLSSPPLVRF----------------------- 491

  Fly   767 RNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPE-GESQPSTE 830
                  :||                      ..|.:...::|..:.|..|..:|.| |..:.:.:
  Rat   492 ------IEP----------------------DSPAERCGLLQVGDRVLAINGIATEDGTMEEANQ 528

  Fly   831 V--DLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGD 893
            :  |..::.:.::.:..|:.|          |.|...|...|.:.:||.|...:...|.:...|
  Rat   529 LLRDAALARKVVLEIEFDVAE----------SVIPSSGTFHVKLPKRRGVELGITISSASRKRG- 582

  Fly   894 VPTPGIGEEESPPKEPLSKHNRTPKMICH---VFESDEAQFIAQSIGQAFQVAYMEFLKANGIEN 955
                          |||...:.....:.|   ..|..:......:|  ......||:......:.
  Rat   583 --------------EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNI--RLDHCPMEYAVQILRQC 631

  Fly   956 ESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIAN 1020
            |.|.|....::..||     ||.|.........|:   |..|..||:.|  ||.......::|:.
  Rat   632 EDLVKLKIRKDEDNS-----DEQESSGAVSYTVEL---KRYGGPLGITI--SGTEEPFDPIIISG 686

  Fly  1021 LMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVK 1069
            |...|.|.|.|.:::||:::|||.:||.|.|||.....::.|.....:|
  Rat   687 LTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	28/184 (15%)
		PDZ_signaling	988..1065	CDD:238492	26/76 (34%)
		PDZ_signaling	1092..1151	CDD:238492
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492	6/26 (23%)
		PDZ_signaling	153..236	CDD:238492	26/166 (16%)
		PDZ_signaling	251..334	CDD:238492	18/82 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		15/78 (19%)
		PDZ_signaling	456..544	CDD:238492	20/160 (13%)
		PDZ_signaling	557..640	CDD:238492	17/99 (17%)
		PDZ_signaling	657..737	CDD:238492	27/84 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900