DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Apba2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001278095.1	Gene:	Apba2 / 11784	MGIID:	1261791	Length:	750	Species:	Mus musculus

Alignment Length:	882	Identity:	332/882 - (37%)
Similarity:	443/882 - (50%)	Gaps:	202/882 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 HRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELE-ANLRRHSRNFTLSPETTDYD 407
            ||:.....|.||.|     |..|.||.::|       ...|.|| ..||..|.    :||..:..
Mouse    16 HRARPGPIPHDQEP-----ESEDTELPLES-------YVPTGLELGTLRPESP----TPEEQECH 64

  Fly   408 SNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLS--------------------------SGHAS 446
            ::..|.||.|:.:|..::.......:|..|:|::                          ..|..
Mouse    65 NHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIRYCPEDDSYLEGMDCNGEEYIAHGAHPV 129

  Fly   447 DTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPP 511
            ||:.....|.| ...|.....|.|.....:...|                        ..||:
Mouse   130 DTDECQEAVED-WTDSVGPHTHSHGAENSQEYPD------------------------GHLPI-- 167

  Fly   512 APPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPV---TAG 573
              |...|..:|:.|..|            |.||.:...:.......|.:..:| |.:|.   ...
Mouse   168 --PEDDPTVLEVHDQEE------------DGHYCSSKESYQDYYPPETNGNTG-GASPYRMRRGD 217

  Fly   574 GSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAAD 638
            |.|..| ..:|.:.:.||:.:|..                             |:|::|..|:.:
Mouse   218 GDLEEQ-EEDIDQIVAEIKMSLSM-----------------------------TSITSASEASPE 252

  Fly   639 EEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQT 703
            ..|:.|                        ..::.|....:..||..|..: ..|..: |..|:.
Mouse   253 HMPELD------------------------PGDSTEACPPSDTGHGPGRQE-ARPKSL-NLPPEV 291

  Fly   704 YSTATIRQGIGT-SLTPN------SPDICQIVGTTDISISSPEKLQFT--KSPTGSIKSLKDSAN 759
            .....:::|:.| :.||.      ...:|.       .:..|.|.|.:  ..||       |:.|
Mouse   292 KHPGDLQRGLKTKTRTPEERPKWPQEQVCN-------GLEQPRKQQRSDLNGPT-------DNNN 342

  Fly   760 --SDKKAKSRNK----EGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKA 818
              ..||..|...    .|..|.:.||:|::|.|.|||||||:.|..|:|:.|||||:|||||:|.
Mouse   343 IPETKKVASFPSFVAVPGPCEAEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKR 407

  Fly   819 LA----------PEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMA 873
            :.          .||::|..|||||||||::|.|||.|.:|.||||||||||||||||::|||||
Mouse   408 MQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMA 472

  Fly   874 RRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQ 938
            ||| :|.|.....|.:      |||..|.:           :..|||||||||::||.|||||||
Mouse   473 RRR-MPRSASQDCIET------TPGAQEGK-----------KQYKMICHVFESEDAQLIAQSIGQ 519

  Fly   939 AFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVV 1003
            ||.|||.|||:||||..|.|::: :|.:::|:||::.|:|..|:..|..||:.:.|.||||||||
Mouse   520 AFSVAYQEFLRANGINPEDLSQK-EYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVV 583

  Fly  1004 IVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAV 1068
            :|||||||:||||::||:|:.|.|||.|:|:||||:::|||.|||||||:|||..|:..||||.|
Mouse   584 VVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQV 648

  Fly  1069 KFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVP 1133
            |..:|.||||..|.|.||...:|||||||||:||||:||||||||||||||||||||.|||||..
Mouse   649 KLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATA 713

  Fly  1134 HDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            |:.||:.||:|||||.|||||.:|||||||||||:||
Mouse   714 HEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	104/188 (55%)
		PDZ_signaling	988..1065	CDD:238492	50/76 (66%)
		PDZ_signaling	1092..1151	CDD:238492	47/58 (81%)
Apba2	NP_001278095.1	PTB_X11	365..536	CDD:269919	105/188 (56%)
		PDZ	569..652	CDD:395476	54/82 (66%)
		PDZ	662..733	CDD:395476	53/70 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		25/93 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..346		50/313 (16%)
		STXBP1-binding	185..271		20/140 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3706
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8726
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.800