DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and PARD3B

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	750	Identity:	144/750 - (19%)
Similarity:	240/750 - (32%)	Gaps:	251/750 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 LIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQP 315
            |.|:|:.:::......|:.|          ..|:  |....||.|.:....:.||....:|:.:|
Human    73 LADVVEDKDKLIAVFEEQEP----------LHKI--ESPSGNPADRQSPDAFETEVAAQLAAFKP 125

  Fly   316 --QEYPATPMEQAYIGQRLARIPKDELYMVHRS--PTKKPPSDQNPSTAYQEHNDIELYIDSNSR 376
              .|...|| ....:|..|         :|.||  |...||:|..||.::.....::|.:..
Human   126 IGGEIEVTP-SALKLGTPL---------LVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPD--- 177

  Fly   377 SSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFGKL-------YTSMP 434
            |:.:|.|.|:   |.........||.|.|      .|..::..:....:.|.|       ::|:.
Human   178 STQNLEDREV---LNGVQTELLTSPRTKD------TLSDMTRTVEISGEGGPLGIHVVPFFSSLS 233

  Fly   435 -----VLEDGLSSGHASDTE------------NNVSVVCDK---------QQSSQSQPVHEH--- 470
                 :...|:.....|..|            |||.:| ||         :|:.:|..|..|
Human   234 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV-DKTFAQAQDVFRQAMKSPSVLLHVLP 297

  Fly   471 NGNGERLE----NDYNVMSASLATLTTDASQSALISDFASLPMPPAPPP--------------SS 517
            ..|.|:.|    ...|:...:...|.|                 ..|||              :.
Human   298 PQNREQYEKSVIGSLNIFGNNDGVLKT-----------------KVPPPVHGKSGLKTANLTGTD 345

  Fly   518 PPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAAS 582
            .|:   .|||.|:........|           .|||..:..|      ::|:...||
Human   346 SPE---TDASASLQQNKSPRVP-----------RLGGKPSSPS------LSPLMGFGS------- 383

  Fly   583 EIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPD----SPVWVPR---KGTTISTAQGAAADEE 640
              .:..|:|:..|::.   ||.|.|  .|:..|..    .|::|..   ||..|.
Human   384 --NKNAKKIKIDLKKG---PEGLGF--TVVTRDSSIHGPGPIFVKNILPKGAAIK---------- 431

  Fly   641 PDTDLET-DRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTY 704
             |..|:: ||:|.....|                          :.|.:.......:.::|....
Human   432 -DGRLQSGDRILEVNGRD--------------------------VTGRTQEELVAMLRSTKQGET 469

  Fly   705 STATIRQGIGTSL---TPNSPDICQIVGTTDISISSPEKLQF--TKSPTGSIKSLKDSANSDKKA 764
            ::..|.:..|..|   ....||.|.      :|:.:.|:|.|  ..:.:|| ..|..|...:|..
Human   470 ASLVIARQEGHFLPRELKGEPDCCA------LSLETSEQLTFEIPLNDSGS-AGLGVSLKGNKSR 527

  Fly   765 KSRNKEGLLEPKVLIEGVLFR-ARYLGSTQLVC-EGQPTKSTRMMQAEEAVSRIKALAPEGESQP 827
            ::....|:....::..|..|: .|...:.||:. .|:........:|.|.:.|  :::.||..:.
Human   528 ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR--SMSMEGNIRG 590

  Fly   828 STEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDL----------VVLMARRRFVPNSV 882
            ..::                  :::....|.:...|:.|..          .|..:||.
Human   591 MIQL------------------VILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRN------ 631

  Fly   883 VDPSITSPLGD-----------VPTPGIGEEESPP 906
             |.||..|||.           :|..|..|.|.||
Human   632 -DNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	28/154 (18%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873	22/99 (22%)
		PDZ_signaling	209..296	CDD:238492	16/87 (18%)
		PDZ_signaling	395..475	CDD:238492	19/121 (16%)
		PDZ_signaling	509..597	CDD:238492	17/108 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900