DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and USH1C

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens

Alignment Length:	259	Identity:	61/259 - (23%)
Similarity:	98/259 - (37%)	Gaps:	62/259 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 LNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPK 907
            |.:.|:|.:.:|..||    .|.|             |.|.|....:..|......:.|:..||
Human   622 LPSALEEALSNHPFRT----GDTG-------------NPVEDWEAKNHSGKPTNSPVPEQSFPP- 668

  Fly   908 EPLSKHNRTPKMIC----------------HVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENE 956
                    |||..|                .|....|..||           |...:|:..:..|
Human   669 --------TPKTFCPSPQPPRGPGVSTISKPVMVHQEPNFI-----------YRPAVKSEVLPQE 714

  Fly   957 SLAKEMDYQEVLNS-----QEIFGDELEIFAKKELQ-KEVVVPKAKGEILGVVIVESGWGSMLPT 1015
            .|.:.:.||.....     :|.| |...:|..:::. |:|.:.:.|.|....:.:|.|..|.:..
Human   715 MLKRMVVYQTAFRQDFRKYEEGF-DPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGK 778

  Fly  1016 VVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA--VKFTVVPCPP 1077
            ||::.:...|||.|.|.:..||:::||||..:....|:..::.::.|.||..  :...|..|||
Human   779 VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPP 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	25/126 (20%)
		PDZ_signaling	988..1065	CDD:238492	22/76 (29%)
		PDZ_signaling	1092..1151	CDD:238492
USH1C	XP_016872564.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900