DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and whrna

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	991	Identity:	191/991 - (19%)
Similarity:	321/991 - (32%)	Gaps:	273/991 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NSNSCSDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNS 66
            ||.:.|..|..:.|...|..:|......:::...|.......:|.|:::      |.....:||.
Zfish    16 NSVASSARSLSANVKKLHNALNLLLSDLEREQFIHCLNVYHSKRNVYDL------VQTLKVILNV 74

  Fly    67 PDLNGELSYVPL---------------QGL-----------SPSGG--GVQGSGSYGSN------ 97
            |.....|..:.|               :||           .|.|.  |...|.::|:|
Zfish    75 PSKRQLLPMLRLVIPRSDQLLFDQYTSEGLYLKSEIHARNGDPDGAQEGANSSPTHGANFPASQV 139

  Fly    98 ---AGRDS---------------GSYYYQRP--QLHQIRLGR---SPGSQFETRDVLPQG----- 134
               ...||               |..:...|  ::.|:.|.|   :.|..|..|.....|
Zfish   140 ALRGSPDSISTSSDGTATLIPLLGRNFLPEPPGEIRQVILKRHKSNEGLGFSIRGGSEHGVGIYV 204

  Fly   135 -LASPGSPTDVGKADGQCLRDGEIV------VFDDIDTNWMNKASSGQRPGSNEDVLKVTK---- 188
             |..|||     .|:.:.||.|:.:      |||.:               ::.|.:||.|
Zfish   205 SLVEPGS-----LAEKEGLRMGDQIMKVNDKVFDRV---------------THADAVKVLKGSKK 249

  Fly   189 ------MIGQLP-------------------------IAEYEGSP-RRFGSQPNTN-TITMGGPR 220
                  .:|::|                         :||:..:. ||..||..:: .:...|..
Zfish   250 LCMSVRSVGRIPGGYITNHVYTWVDPQGRSVSPPPDLLAEHRSATLRRSNSQGRSHMQLLQDGDE 314

  Fly   221 K---------RPPGFPQRVSPTTSVANNATAAAKASVGNL--IDLVDHEEERSGTLREKTPTFDY 274
            |         |..|...|.....|:....|...:.|....  |.:.|...|.:|......|
Zfish   315 KKVNLVLDDGRSLGLMIRGGAEYSLGIYITGVDRGSAAECGGIKVGDQILEVNGRSFLSIP---- 375

  Fly   275 LYEFSETRKVLE--EFFKANPEDEKRYTDYTTESGDD--VASSQPQEYPAT------PMEQA--- 326
               ..|..:||:  .......:|..|.....|..|:.  :||||..:..|:      .::|.
Zfish   376 ---HDEAVRVLKSSHHLMMTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSVTGISLDQGAST 437

  Fly   327 ------YIGQRLARIPKDELYMVHRSPTKK-------PPSDQNPSTAYQEHNDIELYIDSNSRSS 378
                  |.|...:::....|....|:..::       .|..|......||:.|..:.::....:.
Zfish   438 SAKGGFYKGVAGSQVTLSSLVNQSRAMLEEQARHLLTEPERQTMGYYIQEYRDGHVGVEQLVMAL 502

  Fly   379 GDLADTELEANLRRHSRNFTLSPETTDYDSNC--GDLDSLSNDINCPTDFGKLYTSMPVLEDGLS 441
            .:|.:|..:.:|....|......:...:|...  .::|:|.........|...: ||....|.|:
Zfish   503 FELFNTHAKFSLLSEVRGIVTPQDVEKFDGLVLRREIDALKARQGGGAGFQDSF-SMVSYPDTLA 566

  Fly   442 SGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFAS 506
            |..||...|..      ..|:::..|.|:||....||:     |.:|..::.|...|.  ||
Zfish   567 SSSASFMTNTT------LSSARNDGVAENNGEQGSLEH-----SNALPDISLDEVHST--SD--- 615

  Fly   507 LPMPPAPPPSSPPQIEIADASE-SMTMVPDADNPLDSHYGAVYAAALGGTHTEKS----AGSGLG 566
              .||:..|..||.::...:.: :::..|.:    .|....:|..|...:||.:|    |.....
Zfish   616 --SPPSFKPPPPPGLQRRPSRKATLSKRPSS----SSSQSGLYFTAPSRSHTRESKHPKAPKAFM 674

  Fly   567 VTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDS------------- 618
            ..|.|....:|   ||::....:.......|.:: |.|.|......|..|.:
Zfish   675 SPPGTLKIDVP---ASQLSVVSQHPIGPFPRVQS-PNKAKPAQSSSPIPPPAPNVPAPPGPPPPP 735

  Fly   619 -----PVWVPRKGTTISTAQGA--------AADEEPDTDLETDRLLGQQRHDEQDFFAD--QSLA 668
                 |...|.|.|..|.|...        ..:.||  |:...|.|.|.|.......:|  |:|:
Zfish   736 PPPLPPPSCPDKPTPSSPASNQHFVMVEVHRPNAEP--DVNEVRPLPQVRGGTLSQLSDSGQTLS 798

  Fly   669 DNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPD---------- 723
            :::   |.||..:|.|   |.:.:|.|.....|        |.|.|...|...|.
Zfish   799 EDS---GVDIPESGRL---SKDTSPRPARTRAP--------RDGHGGGETSAKPPGLLEPMSTLV 849

  Fly   724 -ICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRAR 787
             :.:...|..|:|.....   |:.|...|.:::...::....:.:..:.:||    :.||..|.:
Zfish   850 RVAKSASTLGIAIEGGAN---TRQPLPRIVTIQRGGSAHNCGQLKVGQVILE----VNGVSLRGK 907

  Fly   788 -YLGSTQLVCEGQPTK 802
             :..:.:|:.|...||
Zfish   908 EHREAARLIAEAFKTK 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	7/29 (24%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822	12/82 (15%)
		PDZ_signaling	174..255	CDD:238492	22/100 (22%)
		PDZ_signaling	314..394	CDD:238492	15/86 (17%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	11/78 (14%)
		PDZ_signaling	848..919	CDD:238492	12/77 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900