DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and pdzd7a

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	1301	Identity:	225/1301 - (17%)
Similarity:	366/1301 - (28%)	Gaps:	570/1301 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDSSNESMVNPPHIQMNFGQQAQQQ-QSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSP--- 67
            ||::.:.|.|..|.....|...... ..:.|::||:|:     .:|:.||  .....::|:|
Zfish     5 SDTARKDMTNGAHPSAQPGPSGTSTLPRYLHKKQQRQR-----GVRSSSP--MGRVILINAPVDG 62

  Fly    68 -DLNGELSYVPLQ-------GLSPSGGGVQGSGSYGSNAGRDS---------------------- 102
             |.:.::..:.:.       |.|..||...|.|.:.|....||
Zfish    63 GDDSEDIHTITVDKSEDGHLGFSVRGGSEHGLGIFVSKVEDDSTAEMAGLCVGDKLVEVNGISLE 127

  Fly   103 ------------GSYYYQRPQLHQIRLGRSPGSQF-----------ETRDVLPQGLASPGSPTDV 144
                        |:   .|.::...|:|:.||.::           ..|.|:.:...:|...:..
Zfish   128 SITMSSAVKVLTGN---NRLRMVVRRVGKVPGIRYSKEKTTWVDLIHRRMVVEESGRTPSEASSD 189

  Fly   145 G----------KADGQCL----RDGEI--------------------------------VVFDDI 163
            |          .:|..||    |.|:.                                |.|:||
Zfish   190 GALRRIVHLYTTSDDYCLGFNIRGGKEFGLGIYVSKLDPGGLAEQNGIKMGDQILAANGVSFEDI 254

  Fly   164 ---------------------------------DTNWMNKASSGQRPGSNE--DVLKVTKMIGQ- 192
                                             :.:|:||.::|.:|.|::  |....|..:..
Zfish   255 THSNAVEVLKSHTHVMLTIKEAGRYPAYKEMVAEYSWLNKLANGGQPSSSQGSDSYSSTSSLSSG 319

  Fly   193 LPIAEYEG-----SPRRFGSQPNTNTITMGGPRKRP------------PGFPQRVSPTTSVANNA 240
            .|::...|     .|..|||:.....|:.....:||            |..|..:|.|:.|.:..
Zfish   320 TPVSSLSGLSQVTFPPAFGSEMVDVCISTEDRSRRPSSERIETAIQTDPQDPDTISRTSRVMSTE 384

  Fly   241 TAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTE 305
            |:   ..||..:.|.| ...|.||...:|.||                                .
Zfish   385 TS---RMVGETVLLKD-TVIRRGTAHSRTRTF--------------------------------S 413

  Fly   306 SGDDVASSQPQEYPATPMEQAYIGQRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELY 370
            :||    .:..:.|.|.:..|....|.|         :.||               |.|..:..:
Zfish   414 AGD----KETLDSPKTAVLMALSKPRKA---------IRRS---------------QSHITVSEF 450

  Fly   371 IDSNSRSS-----GDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFGKLY 430
            ..:..|:|     ...:..|.:...|:|.:               |.:::..:.:    ...|.:
Zfish   451 WFATERASCLCGCTSRSRQEDKQKKRKHQK---------------GKVETEGSTL----QRSKTF 496

  Fly   431 TSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNG-ERLENDYNVMSASLATLTTD 494
            .::| .:.|.....:|..:...:...|..:.....|.|..|..| ||.....|::|:...|....
Zfish   497 VTLP-FKSGRRRERSSSRDRKDTGREDGHKGRSKSPKHLDNEPGKERGRPIINLLSSPRETRAGL 560

  Fly   495 ASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPL--DSHYGAVYAAALGGTHT 557
            ..||         |||      ||         |:|.::.|....|  :....||.      .|.
Zfish   561 REQS---------PMP------SP---------ETMALLEDVARKLLNEDEVAAVM------RHC 595

  Fly   558 EKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKL----------------K 606
            ::..                      :...::::...|.....:||||                :
Zfish   596 KRFL----------------------VDRVVEDLVRPLLAILDKPEKLLLLREVRMIIPATDLGR 638

  Fly   607 FCDEVLPTDPD-----------SPVW-VPRKG--------TTISTAQGAAADEEPDTDLETDRLL 651
            |...|||.:.:           |||. .||.|        |.|...:| ....:|..|||.:|
Zfish   639 FDSMVLPFELEAYDILKSRSVRSPVLRSPRHGGTPRRHLITPIPDYRG-GFHLQPVQDLERER-- 700

  Fly   652 GQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNP-----NPMNNSKPQTYSTATI-- 709
                         |.:.|         .....|.|......|     .|:.:....||.|.::
Zfish   701 -------------QLIED---------LERMRLAGLPTGRLPPPRAFTPLLDVPVDTYITDSLRN 743

  Fly   710 ------RQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRN 768
                  |.|...|.:|.|         |:.:..||.: :....|..|:.|..||.....::..||
Zfish   744 RSLSPARSGFSHSESPYS---------TERTGRSPLR-RDNGFPHDSLSSRGDSVPERGRSPYRN 798

  Fly   769 KEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDL 833
                                         |...|:.:.:..:|
Zfish   799 -----------------------------GHRMKTDKSLNGKE---------------------- 812

  Fly   834 FISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDV--PT 896
                                     :.|       .|:.|.||          ..:||..|  |:
Zfish   813 -------------------------VKY-------TVMSAHRR----------SRTPLSQVFAPS 835

  Fly   897 PGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKE 961
            |     |...|||::.|            ||...                            ..|
Zfish   836 P-----EQHWKEPVNGH------------SDSQD----------------------------RTE 855

  Fly   962 MDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVI---VESGWGSMLPTVVIANLMS 1023
            .||  ||.:                   |.:.|.| :.||:.|   :||   .:.|.|.|..:..
Zfish   856 QDY--VLTT-------------------VTISKTK-QSLGISISGGIES---KVQPMVKIEKIFP 895

  Fly  1024 SGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKA 1088
            .|||:....|..|.:|::::|.||.|:........||.|.:..|.:    |...:|:|    ||.
Zfish   896 GGAASTSDVLKAGFELVSVDGESLQGVTHQHAVDAIRRAFSNKAKE----PMEFIVKV----PKR 952

  Fly  1089 L 1089
            |
Zfish   953 L 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	20/180 (11%)
		PDZ_signaling	988..1065	CDD:238492	24/79 (30%)
		PDZ_signaling	1092..1151	CDD:238492
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492	11/82 (13%)
		PDZ_signaling	194..274	CDD:238492	9/79 (11%)
		HN_PDZD7_like	568..645	CDD:259824	16/113 (14%)
		PDZ_signaling	860..948	CDD:238492	27/114 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910