DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sav and MAGI1

DIOPT Version :9

Sequence 1:	NP_788721.1	Gene:	sav / 252554	FlyBaseID:	FBgn0053193	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	399	Identity:	83/399 - (20%)
Similarity:	126/399 - (31%)	Gaps:	118/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GLLSASYANMLQLPQRPHSPAH------------YAVP-----PQQQQHPQIHQQHASTPFGSTL 251
            |.|:....:.|....:..||.|            :|||     |::.:.|.:.....:......|
Human   106 GRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDL 170

  Fly   252 RFDRAAMSIRERQPRYQPTSSPMQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVI 316
            ......:.:...:..|..|..|..|....:......|...|..:.......:.||...:|...|
Human   171 EQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV- 234

  Fly   317 SMRATQSQRSESP-IYSNTTASSATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGAS 380
              .|...:..:.| :.|:.||.|..    .:.|.....|:|..:
Human   235 --HAENEEEDDVPEMNSSFTADSGE----QEEHTLQETALPPVN--------------------- 272

  Fly   381 TSVQSLYVPPRTPPSAVAGAGGSANGSLQKVPSQQSLTEPEEL-PLPPGWATQYTLHGRKYYIDH 444
               .|:...|.|.||             ||.|....|:..:.| |||..|...||.:|..|:|||
Human   273 ---SSIIAAPITDPS-------------QKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDH 321

  Fly   445 NAHTTHW---------NHPLER----EG-----------LPVGWRRVVSKMHGTYYENQYTGQSQ 485
            |..||.|         ..|||.    ||           ||.||.::...::|.||.:....::|
Human   322 NTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQ 386

  Fly   486 RQHPCLTSYYVYTTSAEPPKAIRPEASLYAPP---------------THTHNALV--------PA 527
            .::|.|        .|:..|.:..:.......               |..|:|||        |:
Human   387 YENPVL--------EAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPS 443

  Fly   528 NPYLLEEIP 536
            ||....|:|
Human   444 NPEPAREVP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sav	NP_788721.1	WW	425..454	CDD:278809	14/37 (38%)
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	36/214 (17%)
		WW	303..332	CDD:238122	13/28 (46%)
		WW	361..390	CDD:278809	8/28 (29%)
		PDZ	469..555	CDD:214570
		PDZ	640..723	CDD:214570
		MAGI_u5	722..805	CDD:293271
		PDZ_signaling	819..894	CDD:238492
		PDZ_signaling	968..1062	CDD:238492
		PDZ	1123..1205	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284488at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010