Protein Alignment sav and SAV1

DIOPT Version :9

• Sequence 1: NP_788721.1
• Gene: sav / 252554
• FlyBaseID: FBgn0053193
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_068590.1
• Gene: SAV1 / 60485
• HGNCID: 17795
• Length: 383
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 154/590 - (26%)
• Similarity: 217/590 - (36%)
• Gaps: 220/590 - (37%)

  Fly    15 MLSRRNKEKSQHKEG-VVGKYMKKDTPPDISVINVWSDQRAKKKSLQRCASTSPSCEFHPRSSST 78
            ||||:..:....|.. |.|||:||:|.|.:         |....|..|...|.|
Human     1 MLSRKKTKNEVSKPAEVQGKYVKKETSPLL---------RNLMPSFIRHGPTIP----------- 45

  Fly    79 SRNTYSCTDSQPDYYHARRAQSQMPLQQHSHSHPHSLPHPSHPHVRSHPPLPPHQFRASSNQLSQ 143
             |.|..|                             ||..|           |:.|..|.:.:|:
Human    46 -RRTDIC-----------------------------LPDSS-----------PNAFSTSGDVVSR 69

  Fly   144 NSSNYVNFEQIERMRRQQSSPLLQTTSSPAPGAGGFQRSYSTTQRQHHPHLGGDSYDADQGLLSA 208
            |.|                  .|:|.         .||:.....|:....|...||      |:.
Human    70 NQS------------------FLRTP---------IQRTPHEIMRRESNRLSAPSY------LAR 101

  Fly   209 SYANMLQLPQRPHSPAHYAVPPQQQQHPQIHQQHASTPFGSTLRFDRAAMSIRERQPRYQPTSSP 273
            |.|::         |..|.               :|..|.:.:.|   |:...:...||..:.:.
Human   102 SLADV---------PREYG---------------SSQSFVTEVSF---AVENGDSGSRYYYSDNF 139

  Fly   274 MQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVISMRATQSQRSESPIYSNTTASS 338
            ...|:::..                |..:.:.|..||
Human   140 FDGQRKRPL----------------GDRAHEDYRYYE---------------------------- 160

  Fly   339 ATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGASTSVQSLYVPPRTPPSAVAGAGGS 403
                    ::|.....:|...|         ..:||..|.|:||:.:|                :
Human   161 --------YNHDLFQRMPQNQG---------RHASGIGRVAATSLGNL----------------T 192

  Fly   404 ANGSLQKVPSQQSLTEPEELPLPPGWATQYTLHGRKYYIDHNAHTTHWNHPLEREGLPVGWRRVV 468
            .:||             |:|||||||:..:|:.|||||||||.:||||:|||||||||.||.||.
Human   193 NHGS-------------EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVE 244

  Fly   469 SKMHGTYYENQYTGQSQRQHPCLTSYYVYTTSAEPPKAIRPEASLYAPPTHTHNALVPANPYLLE 533
            |...||||.:....::|.:|||..|...|  ...||...:|:.:     ....:.|||||||...
Human   245 SSEFGTYYVDHTNKKAQYRHPCAPSVPRY--DQPPPVTYQPQQT-----ERNQSLLVPANPYHTA 302

  Fly   534 EIPKWLAVYSEADSSKDHLLQFNMFSLPELEGFDSMLVRLFKQELGTIVGFYERYRRALILE-KN 597
            |||.||.||:.|....||:|::.:|.|.:|:.:..||..||.:||..||..||.||:||:.| :|
Human   303 EIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELEN 367

  Fly   598 RRAGQ 602
            |:..|
Human   368 RKQRQ 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sav	NP_788721.1	WW	425..454	CDD:278809	19/28 (68%)
SAV1	NP_068590.1	WW	202..232	CDD:238122	20/29 (69%)
		WW	237..266	CDD:238122	12/28 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148219
Domainoid	1	1.000	115	1.000	Domainoid score	I6057
eggNOG	1	0.900	-	-		E1_KOG1891
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284488at2759
OrthoFinder	1	1.000	-	-		FOG0006401
OrthoInspector	1	1.000	-	-		oto90680
orthoMCL	1	0.900	-	-		OOG6_110166
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4746
SonicParanoid	1	1.000	-	-		X5360
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.640