DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dyrk1a and Hipk

DIOPT Version :9

Sequence 1:NP_036923.1 Gene:Dyrk1a / 25255 RGDID:2528 Length:763 Species:Rattus norvegicus
Sequence 2:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster


Alignment Length:923 Identity:253/923 - (27%)
Similarity:362/923 - (39%) Gaps:263/923 - (28%)


- Green bases have known domain annotations that are detailed below.


  Rat    50 DQQVSALS----YSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEV 110
            ||.|:|.:    :.:|.||.|..|....|:          |.|||:.... ||....|       
  Fly    43 DQTVTATTDGTRHQEQQQQQLQQQQQQHIL----------RQPATSASTS-SVAAAAT------- 89

  Rat   111 YYAKKKRR--------------H----QQ-----------------GQGDD---------SSHKK 131
              :|:||:              |    ||                 |.|.|         ::|.|
  Fly    90 --SKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTK 152

  Rat   132 ------------ERKVYNDGYDDDNYDYIVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRVE 181
                        ..|..:.|.|.   ||.:...|   .....||:...:|:|:||||||.:.|..
  Fly   153 VATSGGHANTQPPSKRSSSGADG---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGT 214

  Rat   182 QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLY 246
            .|.|||||:||..::..|.||||.:|..:::.:.: ::..|.....|..:||.|||||||..|||
  Fly   215 SEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLY 278

  Rat   247 DLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFG 309
            |.|:...|..:.|...|...:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::|||
  Fly   279 DFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFG 341

  Rat   310 SSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
            |:..:.:.:.. |:|||:||:||::||:|:..|||||||||::.|:..|.||:.|::|.||:..|
  Fly   342 SASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYI 406

  Rat   374 VEVLGIPPAHILDQAPKARKFFEKLPDGT---WSLKKTKDGKRE--YKPPGTRK-LHNIL----- 427
            .:..|:|..|:|:.|.|..|||.:..|.|   |.||.|::.:.|  .|....|| :.|.|     
  Fly   407 SQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQ 471

  Rat   428 -GVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSN 491
             .|.|...||:...|.    .|..:|.||:.|||..|.:.|:.|..||.|||.:.|........|
  Fly   472 VNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCN 532

  Rat   492 SVSTSPAM-----------EQSQSSGTTSSTSSSSGGSSGTSN---------------------- 523
            :|..|..|           .|..|:..|:...||:...:.|.|                      
  Fly   533 NVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGL 597

  Rat   524 ----SGR--ARSDP---THQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAP-----LGWSGTEAP 574
                :||  ||..|   |...:|.      .|..:.|    |...|..|:|     :|.:..:.|
  Fly   598 YQIYNGRSVARQYPQTRTDSFQHQ------LVSNILC----PPSYQTMPSPTKHVVVGSATMQPP 652

  Rat   575 TQVTVE----------------------THPVQ-------ETTFHVA-----PQQNALH------ 599
            .||..:                      |:.||       :|...:|     |||...|      
  Fly   653 LQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDS 717

  Rat   600 -----------HHHGN--------SSHHHH---------HHHHHHHHHGQQALGNRTRPRVYNSP 636
                       .||.|        .|..||         ..|....|.....:..|.:.   :||
  Fly   718 TPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKE---SSP 779

  Rat   637 TNSSSTQDSMEVG---HSHHS---------MTSLSSSTTSSSTSSSS--TGNQGNQAYQNRPVAA 687
            .:....|.:..|.   |:||:         ..|..|...||:.|||:  .|:..:..:.:.||| 
  Fly   780 PHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVA- 843

  Rat   688 NTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAH----YMTEGHLTMRQGADREES 748
                ..|..:......:.||.....|..|...||    ..|||    :..:.|....|.....:.
  Fly   844 ----HAQPYSSSSGHHIVSNCNANGGAGGAVVYQ----QPPAHAHQQHGQQPHPQSSQHPQHVKQ 900

  Rat   749 PMTGVCVQQSPVA 761
            |...:....||.|
  Fly   901 PTITIHDTPSPTA 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dyrk1aNP_036923.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..56 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 11/76 (14%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 9/72 (13%)
PKc_DYRK1 148..484 CDD:271128 140/353 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 18/96 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..679 25/130 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..763 4/18 (22%)
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 137/334 (41%)
PHA03378 <1080..1327 CDD:223065
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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