DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk1a and mnb

DIOPT Version :9

Sequence 1:	NP_036923.1	Gene:	Dyrk1a / 25255	RGDID:	2528	Length:	763	Species:	Rattus norvegicus
Sequence 2:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	442/920 - (48%)
Similarity:	533/920 - (57%)	Gaps:	202/920 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 TGGETSACKPSS-----VRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSDQI 62
            :||...|.:.|.     .|.||.:.....    |..:|.:|:       ::.....|..|.|
  Fly   165 SGGSVDAAQGSGSGGGRQRHAPLYGRFVD----AEDLPATHR-------DVMHHHSSPSSSS--- 215

  Rat    63 QQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG-DD 126
                      ::..:|.|:|..||:||:.|||||||||||||||||||||||||||.||.|| ||
  Fly   216 ----------EVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDD 270

  Rat   127 SSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK 191
            ||:|||||:|||||||||:|||:|||||::||||||||||||||||||||||..||..|||||||
  Fly   271 SSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIK 335

  Rat   192 NKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRG 256
            |||.|||||||||:|||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||||
  Fly   336 NKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRG 400

  Rat   257 VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY 321
            ||||||||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||.|
  Fly   401 VSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHY 465

  Rat   322 IQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD 386
            ||||||||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::||
  Fly   466 IQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLD 530

  Rat   387 QAPKARKFFEKL-PDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 450
            ||.|.||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:|||
  Fly   531 QAHKTRKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYL 594

  Rat   451 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515
            |||||||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:
  Fly   595 KFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGA 652

  Rat   516 GGSSG----------TSNSGRARSD----PTHQHRHS------------GGHFAAAVQ------- 547
            |||||          .|:||...|.    ||.....:            ||..:||.|
  Fly   653 GGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLP 717

  Rat   548 ---------------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE--TT 588
                           |.|.:.|       :......|.|....|....|..:....|....  :.
  Fly   718 LPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSL 782

  Rat   589 FHVAPQQNALHHHHGNSSHHHHHH-------------HH-----HHHH----------------- 618
            .|::|.....|:::.|||:::..|             ||     ::|:
  Fly   783 NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPP 847

  Rat   619 -----HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTSSS 666
                 ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|::
  Fly   848 PPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAA 912

  Rat   667 TSSSSTGNQGNQ---------AYQNRP------------------------------------VA 686
            ......||.|..         .:.::|                                    |:
  Fly   913 GGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVS 977

  Rat   687 ANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGAD-REESPM 750
            :.:...|..|   |.:.|....|..||.|.......|..:|     :.|..|....:| ...|||
  Fly   978 SGSASVGSGG---VGVGVVGQRRHITGPAAQVGISQSVGSG-----SSGSATGASSSDASSSSPM 1034

  Rat   751 TGVCVQQSPV 760
            .||||||:||
  Fly  1035 VGVCVQQNPV 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk1a	NP_036923.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..56		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		17/21 (81%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		13/17 (76%)
		PKc_DYRK1	148..484	CDD:271128	282/336 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		24/33 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		21/80 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679		25/143 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763		12/18 (67%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	284/339 (84%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	270/320 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348900
Domainoid	1	1.000	554	1.000	Domainoid score	I236
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	721	1.000	Inparanoid score	I601
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002707
OrthoInspector	1	1.000	-	-		oto96971
orthoMCL	1	0.900	-	-		OOG6_103522
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.750