DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg1 and pyd

DIOPT Version :9

Sequence 1:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	201/911 - (22%)
Similarity:	345/911 - (37%)	Gaps:	297/911 - (32%)

- Green bases have known domain annotations that are detailed below.

  Rat   203 NTDSLETPT---------YVNGTDADYEYEEITLER-GNSGLGFSIAGGTDNPHIGD-DSSIFIT 256
            |::.|||.:         :..|....:||..:.:.| ...|.|.:::||.||||..: |.||.::
  Fly   220 NSNLLETASTHSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVS 284

  Rat   257 KIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIK 321
            .::.||.|  :.||:|||.|:.||...:.:|.::.||:.|:::|:.|:|.||||.|.:.
  Fly   285 DVLKGGPA--EDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNP------ 341

  Rat   322 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA--------------------------- 359
                     .:.||.|.:||....:|:.:.....||.|
  Fly   342 ---------INAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPI 397

  Rat   360 ----HKDGK-------------------------------LQIGDKLLAV--------------- 374
                .|.||                               ||.||.:..:
  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462

  Rat   375 ----------NSVCLEEVTHEEAVTALK-------NTSDFVY------LKVAKPTSMYINDGYAP 416
                      |.|.|.::|::.||:.|.       ..|..:|      :.....::..:.|.|.|
  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLP 527

  Rat   417 ---------------------PDITNS-----------------------SSQSVDNHVSP---- 433
                                 |:|..:                       |.|.:|..|:|
  Fly   528 GGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGR 592

  Rat   434 SSYLGQTPASPAR------------YSPISKAVLGDDEITREPRKVVLHR-GSTGLGFNIVGGED 485
            |:.:.:.|..|..            ||  |:..|.::..:.|||.:...: ||.|:  .:.||.:
  Fly   593 SAAIDEPPRPPPPRGSSGGAAQEDFYS--SRRQLYEERQSAEPRFISFQKEGSVGI--RLTGGNE 653

  Rat   486 GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEY 550
            . |||::.:..|.||.|.| |..||:|:.||.:|:...:.|:|...|.:....:.::.||..|||
  Fly   654 A-GIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEY 716

  Rat   551 SRFEAKIHDLREQMMNSSVSSGSGSLRTSQK-RSLYVRALFDYDKTKDSGLPSQG-LNFKFGDIL 613
            .                       .:.|:|: .|.:::..|..|.      ||:| :.||.||:.
  Fly   717 D-----------------------EVVTNQRGDSFHIKTHFHCDN------PSKGEMAFKAGDVF 752

  Rat   614 HVINASDD---EWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGQSFNDK 675
            .||:...:   ..||..::....:..:.||||:|.|.|:     |.|.:||:.   .|..:.|:.
  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEE-----LATAQFNAT---KKEMNANES 809

  Rat   676 RKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEP 740
            |......|:....::|..|.:...|.      ..|||.|.:                   .:||.
  Fly   810 RGNFFRRRRSTHRRSKSLSRENWDDV------VFSDSISKF-------------------PAYER 849

  Rat   741 VNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQME 805
            |..:...:.|||::.||:.|...:.|..:|||||.:       |.:|.:
  Fly   850 VVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFST-------PLQDDD---------------- 891

  Rat   806 KDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSM 870
                     ::...:.......:.::|.|.::|||.:||::.||:.||..||.||:.||:|..|.
  Fly   892 ---------KSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSK 947

  Rat   871 ENIMEMNKRL---TDEQARKTFERAVRLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIW 932
            ..|.::...|   ..:.::|..|:..:||:.::..|:..:.....|..|.:::..|:.|....:|
  Fly   948 HVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVW 1012

  Rat   933 V 933
            :
  Fly  1013 M 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492	30/85 (35%)
		PDZ_signaling	317..403	CDD:238492	25/185 (14%)
		PDZ_assoc	404..465	CDD:402299	18/120 (15%)
		PDZ	463..547	CDD:214570	28/84 (33%)
		SH3_DLG1	582..648	CDD:212964	20/69 (29%)
		Guanylate_kin	748..926	CDD:395500	43/180 (24%)
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306	6/28 (21%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	30/86 (35%)
		PDZ_signaling	396..477	CDD:238492	9/80 (11%)
		PDZ_signaling	633..710	CDD:238492	25/80 (31%)
		SH3_ZO	729..790	CDD:212793	19/66 (29%)
		GuKc	831..1007	CDD:214504	51/232 (22%)
		ZU5	2263..2351	CDD:279170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910