Protein Alignment DIP2 and Dip2a

DIOPT Version :9

• Sequence 1: NP_612019.2
• Gene: DIP2 / 252479
• FlyBaseID: FBgn0024806
• Length: 1773
• Species: Drosophila melanogaster
• Sequence 2: XP_006514002.1
• Gene: Dip2a / 64451
• MGIID: 2385920
• Length: 1572
• Species: Mus musculus
• Alignment Length: 1808
• Identity: 908/1808 - (50%)
• Similarity: 1145/1808 - (63%)
• Gaps: 285/1808 - (15%)

  Fly     5 ASLPGYVREKLAELDLELSEGDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNS 69
            |.||..|.|.||||:|||||||||||||||||||||..::...:|..
Mouse    11 APLPAEVLESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGVD------------------ 57

  Fly    70 TNHGNINNDGVIVSSEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAPGYENM 134
                                    |.|.:..:
Mouse    58 ------------------------PCLQTENR--------------------------------- 65

  Fly   135 RPQGGAVGDPGYQNTREPSAFQNQQSTNNSQHRQRRTQRKVTHNEKRYHSEVRQEAVQQALAALK 199
                    .||...|...:..|..::||:              .::|:.|:|..||||.|||..|
Mouse    66 --------IPGPLLTAATAKPQKSRATNS--------------RDERFRSDVHTEAVQAALAKYK 108

  Fly   200 GRPKPSLPMPSKRTSVLNRSPGCNDELDSSTDDESIPEETISPDKEYNYPR-DHISNSILPPEPI 263
            .|   .:||||||.|.|         :.||.:..:.|:.:.:.:.|.:..| ..:::::|.....
Mouse   109 ER---KMPMPSKRRSAL---------VHSSVETYTPPDTSSASEDEGSLRRPGRLTSTLLQSHSG 161

  Fly   264 IKPPIRESSMGSQQHARTDVKQNQITNQKYTAPNSAPERRPPQNLPPLPTSEPLSS--------- 319
            |:|.:.....||.            |:...::.:|.|..|        |.:.|.:|
Mouse   162 IEPWLDRVIQGSS------------TSSSASSTSSHPGGR--------PAAAPSASTALAGLTAH 206

  Fly   320 ------DYPPIAYKRENDFSDKAFKQKQYNAPDITQFNNAHRAADRVTRYVNVSQNELNETD--- 375
                  ..||       |.:....:...|..|.:.......|...|         |.|...|
Mouse   207 AHIDLHSAPP-------DVTTGLVEHSSYERPQMASVRGIPRGHGR---------NVLETADGVP 255

  Fly   376 ANGKWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPNAPKPEGSTMTPVQGEQLS 440
            .|.  :||:||||||||||||||.||.||:.| |.|..:.....|||.|||||..|..::||.||
Mouse   256 VNS--RVSSKIQQLLNTLKRPKRPPLKEFFVD-DFEELLEVQQPDPNQPKPEGDQMAVLKGEPLS 317

  Fly   441 IPAGLPRTLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLLSRAQKIAHALSTKIFSKGPE 505
            :....|.:|..|||.:||...|:|..|.||..||.|.|||||||.||:.|:|:.|..|:.||  .
Mouse   318 VGTNGPLSLLAALQLWGTTQPKAPCLTALDTAGKATCTLTYGKLWSRSLKLAYTLLNKLTSK--N 380

  Fly   506 QVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPPQQVGFLLSSCGITVA 570
            :..|.||||||||:||:||:.|:.|:|||:...|||:|||:||:..|...|||||||.|||:|:|
Mouse   381 EPLLNPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVTLA 445

  Fly   571 LTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEFNVGNLRAD-DSAAAYIEYTT 632
            ||::||.|||||: .|||:|..||||.|.|.|.:  ||.:|||::.  .|..| .|..|||||.|
Mouse   446 LTTDACQKGLPKA-PTGEVATFKGWPPLAWLVIDGKHLTRPPKDWY--PLAQDTGSRTAYIEYKT 507

  Fly   633 DKEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREVGLWHSVLTSVLNGMHVIFIP 697
            .||||.:||||:.::::..|:|||.||.|||.||:..||||||:.||||.|||||:|.||||.||
Mouse   508 SKEGSTVGVTVSHSSLLAQCQALTQACGYTEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVITIP 572

  Fly   698 YALMKLRPSSWMQLITKHRASCCLVKSRDLHWGLLATKDHKDISLSSLRMLLVADGANPWSLSSC 762
            |||||:.|.||:|.:..::|...||||||:||.|||.:..:|:.|||||||:|||||||||:|||
Mouse   573 YALMKVNPLSWIQKVCSYKARAALVKSRDMHWSLLAQRGQRDVCLSSLRMLIVADGANPWSISSC 637

  Fly   763 DQFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSATG----RGVLSMAALSHGVV 823
            |.||:|||::|||.:.|||||||.|..||::|||        |...|    :.||||..||:||:
Mouse   638 DAFLNVFQSRGLRPEVICPCASSPEALTVAIRRP--------PDLGGPPPRKAVLSMNGLSYGVI 694

  Fly   824 RVDSEDSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEICVTSGSTSASYFGLDGMTNS 888
            |||:|:.|:.||:||.|||||.|.:.||:.:|.|.|||||::|||||.|.:|..:|:||.|:|.:
Mouse   695 RVDTEEKLSVLTVQDVGQVMPGASVCVVKVDGAPYLCKTDEIGEICVNSVATGTAYYGLLGITKN 759

  Fly   889 TFKVQPLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKH 953
            ||:..|:      ..||        .|:.:..:.|:|||||:||..||||.|..||||.|..|:|
Mouse   760 TFETVPV------TADG--------VPVSDRPFTRTGLLGFIGPDNLVFVVGKLDGLMVVGVRRH 810

  Fly   954 NADDIIATVLAVEPMRFIYRGRIAVFSIKVLRDERVCVIAEQRPDCSEEESFQWMSRVLQAVDSI 1018
            |||||:||.||||||:|:|||||||||:.||.|:|:.::||||||.|||:|||||||||||:|||
Mouse   811 NADDIVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSI 875

  Fly  1019 HQVGIYCLALVPPNHLPKTPLGGIHLCEARRRFLEGSLHPANVLMCPHTCVTNLPKPRELHQGVQ 1083
            ||||:|||||||.|.|||.||||||:.|.::|||||:|||.|||||||||||||||||:
Mouse   876 HQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQ------ 934

  Fly  1084 TAAKLSSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVGLAEDCE--RKPQLITGVLRWRA 1146
                         ....|||||::|||||.|.|:|:|.||::...||.:  ||...:..||:|||
Mouse   935 -------------KQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRA 986

  Fly  1147 NTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIEPGDHVALIFPPGLDLLCAFY 1211
            :|:|||.:|.|||:||.:..|.||.:||||||::||.|.|:||::.||||||::|||:||:.|||
Mouse   987 HTTPDHPLFLLLNAKGTVTSTATCIQLHKRAERVAAALMEKGRLDAGDHVALVYPPGVDLIAAFY 1051

  Fly  1212 GCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPIIKLLKSREAATSIDPKTWPP 1276
            ||||.|.:|:|:||||||||.||||||:|||:||||..|||.|.|.:||||:|||.::|.:|||.
Mouse  1052 GCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLSTQAITRLLKSKEAAAAVDVRTWPT 1116

  Fly  1277 ILDIDDNPKRKYAGI-ATVSFDSSAYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRH 1340
            |||.||.||:|.|.| ...|.|..|||||||||.|.|:||.::|.:.|:||.|:||.|||||||.
Mouse  1117 ILDTDDIPKKKVASIFRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQ 1181

  Fly  1341 VALCLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCT 1405
            :|:||||||||||.:|.|..|||||.|:|:.|.|:|:|.|||||.:||::.|.|||||.|:|:||
Mouse  1182 IAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCT 1246

  Fly  1406 KALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAI 1470
            |.|.....:|:.:.::|.|||||:||||||||:.|||.|.|||:.|||..|.|||:||||||.||
Mouse  1247 KGLGAQTGALRMKGVNLSCVRTCMVVAEERPRISLTQSFSKLFKDLGLPARAVSTTFGCRVNVAI 1311

  Fly  1471 CV----------QGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIANP 1525
            |:          ||.:..:...|||||||||::||.|||||:|:||.::||||:|||||||||:.
Mouse  1312 CLQPNRLGKLAEQGTTGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHT 1376

  Fly  1526 ETKGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTE 1590
            ||||..||||||||||.:||||.||:|:||:||.:.|||:|:|..|.|..::|||||||||||||
Mouse  1377 ETKGPLGDSHLGEIWVSSPHNATGYYTVYGEETLHADHFSARLSFGDTQTIWARTGYLGFLRRTE 1441

  Fly  1591 CSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVY 1655
            .:.::.                                                    |.|||:|
Mouse  1442 LTDASG----------------------------------------------------ERHDALY 1454

  Fly  1656 VVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNESEALDLVPLVT 1720
            |||::||.:.||||.|||||||.||:|.|:.|||||||||||||||||||||.|.:|||||.|||
Mouse  1455 VVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVT 1519

  Fly  1721 NTVLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1773
            |.|||:|.|:|||||:|||||:|||||||||||||||||||||||||||||||
Mouse  1520 NVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995	33/109 (30%)
		ARG80	33..369	CDD:227400	61/351 (17%)
		PRK09192	470..1061	CDD:236403	348/597 (58%)
		Dip2	470..1054	CDD:213273	343/590 (58%)
		AMP-binding	1142..1587	CDD:278902	281/455 (62%)
		AFD_class_I	1159..1762	CDD:302604	364/613 (59%)
Dip2a	XP_006514002.1	DMAP_binding	10..122	CDD:368923	58/210 (28%)
		Dip2	342..918	CDD:341231	350/602 (58%)
		Dip2	994..1568	CDD:341231	374/625 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831114
Domainoid	1	1.000	613	1.000	Domainoid score	I190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1698	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52530
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001187
OrthoInspector	1	1.000	-	-		otm44120
orthoMCL	1	0.900	-	-		OOG6_101035
Panther	1	1.100	-	-	O	PTHR22754
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1757
SonicParanoid	1	1.000	-	-		X1019
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930