DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and Acsf2

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	117/679 - (17%)
Similarity:	224/679 - (32%)	Gaps:	201/679 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 RPKRRPLPEFYEDNDIE--LEIAANTKDPNAPKPEGSTMTPVQGEQLS--IPAGLPRTLECALQR 455
            |..|.||...:.::.::  ...::...|...|.|.|. ::.:||...|  :...:...|:...||
  Rat    21 RGPRTPLSRPWPNSKLQGVRAFSSGMVDCTNPLPIGG-LSYIQGHTDSHLVNKTVGECLDATAQR 84

  Fly   456 YGTNSFKSPMATVLDPNGKV------TTTLTYGKLLSRAQKIAHALSTKIFSKGPEQVTLKPGDR 514
            :              ||.:.      ...|.:.:|.....:.|..|.:         :.|:.|||
  Rat    85 F--------------PNREALVIIHENIRLNFAQLKEEVDRAASGLLS---------IGLRKGDR 126

  Fly   515 VALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPPQQVGFLLSSCG-------ITVALT 572
            :.:..||:      .||            :.:.|:::     |.|.:|.|..       :...|.
  Rat   127 LGMWGPNS------YAW------------VLIQLATA-----QAGIILVSVNPAYQASELEYVLR 168

  Fly   573 SEACLKGL--PKSTTTGE------------------IAKLKGWPRLQWFVTEHLPKP-------- 609
            ...| ||:  ||...|.:                  ..|.:..|.|...::...|.|
  Rat   169 KVGC-KGIVFPKQFKTQQYYNILKQVCPELEKAQPGALKSERLPDLTTVISVDAPLPGTLLLDEV 232

  Fly   610 ----PKEFNVGNLRADDS-AAAY----IEYTTDKEGSVMGVTVTRAAMINHC----RALTMACHY 661
                .||.|:..||.... .:.|    |::|:...|:..|.|::...::|:.    :.|.|....
  Rat   233 VAAGGKEQNLAQLRYHQGFLSCYDPINIQFTSGTTGNPKGATLSHHNIVNNSNLIGQRLKMPAKT 297

  Fly   662 TEGETIVCVLDFKREVGLWHSVLTSVLNGMHVIFIPYALMKLRPS----SWMQLITKHRASCCLV 722
            .|...:|........:|.....:.||::|.       .|:...||    ..::.|::.:.: .|.
  Rat   298 AEELRMVLPCPLYHCLGSVGGTMVSVVHGA-------TLLLSSPSFNGKKALEAISREKGT-LLY 354

  Fly   723 KSRDLHWGLLATKDHKDISLSSLRMLLVADGANPWSLSSCDQFLSVFQAKGLRSDAICPCASSSE 787
            .:..:...:|...|......:::|..::|....|..|              :|  ||....:..|
  Rat   355 GTPTMFVDILNQPDFSSYDFTTIRGGVIAGSLAPPEL--------------IR--AIISKMNMKE 403

  Fly   788 VFTVSLRRPGRGSCGFSPSATGRGVLSMAALSHGVVRVDSEDSLTSLTLQDCGQVMPAAQMVVVR 852
            :..|      .|:...||                |..::..:..........|::||..:..:|.
  Rat   404 LVVV------YGTTENSP----------------VTFMNFPEDTLEQKAGSVGRIMPHTEAQIVN 446

  Fly   853 SEGPPVLCKTDQVGEICVTSGSTSASYFGLDGMTNSTFKVQPLLEELEQPKDGNGTVNIISKPIG 917
            .| ...|.|.:..||:|:........|:|....|..|                          :|
  Rat   447 ME-TGELTKLNMPGELCIRGYCVMQGYWGEPQKTFET--------------------------VG 484

  Fly   918 EDFYVRSGLLGFLGPGGLVFVCG-SRDGLMTVTGRKHNADDIIATVLAVEPMRFIYR-GRIAVFS 980
            :|.:.|:|.:..:...|...:.| |:|  |.:.|.::        :...|...|.:: .::....
  Rat   485 QDRWYRTGDIASMDEQGFCRIVGRSKD--MIIRGGEN--------IYPAELEDFFHKHPQVQEAQ 539

  Fly   981 IKVLRDERV------CVIAEQRPDCSEEE 1003
            :..::|:|:      |:..:.....:|||
  Rat   540 VVGVKDDRMGEEICACIRLKSGETTTEEE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403	103/600 (17%)
		Dip2	470..1054	CDD:213273	103/600 (17%)
		AMP-binding	1142..1587	CDD:278902
		AFD_class_I	1159..1762	CDD:302604
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	109/643 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900