DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and dip2ca

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	XP_009295792.1	Gene:	dip2ca / 563890	ZFINID:	ZDB-GENE-031118-39	Length:	1618	Species:	Danio rerio

Alignment Length:	1818	Identity:	939/1818 - (51%)
Similarity:	1177/1818 - (64%)	Gaps:	259/1818 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPGYVREKLAELDLELSEGDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNSTN 71
            ||..||.:||||:|||||||||||||||||:|||..:|..|.|
Zfish     9 LPLEVRARLAELELELSEGDITQKGYEKKRSKLLGAYLPHPPG---------------------- 51

  Fly    72 HGNINNDGVIVSSEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAPGYENMRP 136
                                                   .:|:|:....|....:.|..|...|.
Zfish    52 ---------------------------------------LEASMAHDRRPPMAPSSASRYHRRRS 77

  Fly   137 QGGAVGDPGYQNTREPSAFQNQQSTNNSQHRQRRTQRKVTHNEKRYHSEVRQEAVQQALAALKGR 201
            .|          ||                            ::||.|:|..||||.|||..|.|
Zfish    78 SG----------TR----------------------------DERYRSDVHTEAVQAALAKHKER 104

  Fly   202 PKPSLPMPSKRTSVLNRS-------PGCN--------DELDSSTDDESIPEETISPDKEYNYPRD 251
             |.::||||||.|::.::       ||.:        .:..|.:::|....|......:.:...:
Zfish   105 -KMAVPMPSKRRSLVVQTSMDAYTPPGLSPLSSLPPLTDTSSGSEEEGGQGEGTPTSSQGSVSME 168

  Fly   252 H-ISNSILPPEPIIKPPIRESSMGSQQHAR-TDVKQNQITNQKYTAPNSAPERRP----PQNLPP 310
            | ||.:|..............|.||....| .||.......:.....:.:.:|:.    .:|...
Zfish   169 HWISRAIHQGSTTSSSSSSTQSGGSGAAGRLADVLAQTHMGKSGPIAHLSLKRKTMLGVAENGNS 233

  Fly   311 LPTSEPLSSD--YPPIAYKRENDFSDKAFKQKQYNAPDITQFNNAH---------RAADRVT-RY 363
            |..|....||  :||.....||..:          .||:|.:.:.|         ....|.| :|
Zfish   234 LRRSCEFGSDLLWPPPLESEENHSA----------PPDVTTYTSEHPVQVERPQVSTVPRTTPKY 288

  Fly   364 VNVSQNELNETDANG---KWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPNAPK 425
            .|.   ||.|| .:|   ..:||||||||:||||:|:|.||.||:.| |.|..:.....|||.|:
Zfish   289 GNA---ELMET-GDGVPVSSRVSAKIQQLVNTLKQPRRPPLREFFVD-DFEELLEVQQPDPNQPR 348

  Fly   426 PEGSTMTPVQGEQLSIPAGLPRTLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLLSRAQK 490
            |||:.|.|::||.|.:....|.:||.||||:||.|.|:|..|.:|.|||....||||||.||:.|
Zfish   349 PEGAQMVPIRGEPLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYVLTYGKLWSRSIK 413

  Fly   491 IAHALSTKIFSKGPEQVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPP 555
            :|:.:..|:.:|  ::..::||||||||:|||||.:|:.|:|||:...:||:|||:||:..|...
Zfish   414 VAYNILHKLGTK--QEPMVRPGDRVALVFPNNDPAAFMVAFYGCLLAEVVPVPIEVPLTRKDAGS 476

  Fly   556 QQVGFLLSSCGITVALTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEFNVGNL 618
            ||:||||.|||:||||||:||.|||||. .||||.:.||||:|.|||||  ||.|||::: ..::
Zfish   477 QQIGFLLGSCGVTVALTSDACHKGLPKG-PTGEIPQFKGWPKLLWFVTESKHLSKPPRDW-FPHI 539

  Fly   619 RADDSAAAYIEYTTDKEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREVGLWHSV 683
            :..::..|||||.|.|:|||:||||||.|::.||:|||.:|.|||.|.||.|||||::|||||.:
Zfish   540 KDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQSCGYTEAEIIVNVLDFKKDVGLWHGI 604

  Fly   684 LTSVLNGMHVIFIPYALMKLRPSSWMQLITKHRASCCLVKSRDLHWGLLATKDHKDISLSSLRML 748
            ||||:|.||||.|||:|||:.|.||:|.:.:::.....|||||:||.|:|.:|.:||:|||||||
Zfish   605 LTSVMNMMHVISIPYSLMKVNPLSWIQKVCQYKGKVACVKSRDMHWALVAHRDQRDINLSSLRML 669

  Fly   749 LVADGANPWSLSSCDQFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSATGRGVL 813
            :||||:||||:||||.||:|||:||||.:.|||||||:|..||::|||    ...|....|||||
Zfish   670 VVADGSNPWSISSCDAFLNVFQSKGLRPEVICPCASSAEALTVAIRRP----TDDSNQPPGRGVL 730

  Fly   814 SMAALSHGVVRVDSEDSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEICVTSGSTSAS 878
            ||..||:||:|||||:.|:.||:||.|.|||.|.|.||:.||.|.||:||::||:||.|.:|..|
Zfish   731 SMQGLSYGVIRVDSEERLSVLTVQDVGTVMPGALMCVVKPEGVPQLCRTDEIGELCVCSIATGMS 795

  Fly   879 YFGLDGMTNSTFKVQPLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPGGLVFVCGSRD 943
            |:||.|||.:||:|.|:              .|...||.|..::|:|||||:|||||||:.|..|
Zfish   796 YYGLSGMTKNTFEVFPM--------------TISGAPISEYPFIRTGLLGFIGPGGLVFISGKMD 846

  Fly   944 GLMTVTGRKHNADDIIATVLAVEPMRFIYRGRIAVFSIKVLRDERVCVIAEQRPDCSEEESFQWM 1008
            |||.|:||:||||||:||.||||||:|:|||||||||:.||.|||:.|:||||||.:||:|||||
Zfish   847 GLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVVVAEQRPDSTEEDSFQWM 911

  Fly  1009 SRVLQAVDSIHQVGIYCLALVPPNHLPKTPLGGIHLCEARRRFLEGSLHPANVLMCPHTCVTNLP 1073
            ||||||:||||.||::||||||.|.|||||||||||.|.::.||||||||.||||||||||||||
Zfish   912 SRVLQAIDSIHNVGVFCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLP 976

  Fly  1074 KPRELHQGVQTAAKLSSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVGLAEDCE--RKPQ 1136
            |||:                   ....:|||||||||||.|.|:|:|.|||:|..||.:  ||..
Zfish   977 KPRQ-------------------KQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFL 1022

  Fly  1137 LITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIEPGDHVALIFP 1201
            .::.||:|||.|:|||::||||:|:||:..:|||.:|||||||||.:|.|||.::.||||||::|
Zfish  1023 FLSEVLQWRAQTTPDHVLFTLLSSRGAVLSSLTCLQLHKRAEKIATMLMERGHLQDGDHVALVYP 1087

  Fly  1202 PGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPIIKLLKSREAA 1266
            ||:||:.|||||||.|.:|||:|||||||:.||||||:|||:||:|..|::.|.|.|||||:||:
Zfish  1088 PGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACVMTTQIISKLLKSKEAS 1152

  Fly  1267 TSIDPKTWPPILDIDDNPKRKYAGIATVSF-DSSAYLDFSVSTCGRLSGVNITHRSLSSLCASLK 1330
            .::|.:||||:||.||.||:|...:...|. |:.|||||||||.|.|:||.::|.:.|:.|.|:|
Zfish  1153 AAVDVRTWPPVLDTDDLPKKKPPQLYKPSNPDTLAYLDFSVSTTGMLAGVKMSHTATSAFCRSIK 1217

  Fly  1331 LACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTF 1395
            |.|||||||.||:|||||||||||:|.|..|||||.||||.|.|:|.||:|||..:||.||||||
Zfish  1218 LQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPSELEVNPALWLLAVSQFRVRDTF 1282

  Fly  1396 CSYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVST 1460
            |||.|:|||||.|.....|||.|.:||..|||||||||||||:.|||.|.|||:.|||:.|.|||
Zfish  1283 CSYSVMELCTKGLGLQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVST 1347

  Fly  1461 SFGCRVNPAICV----------QGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLL 1515
            |||||||.|||:          ||.|..:...|||||||||::||.|||||:|:||.::||||:|
Zfish  1348 SFGCRVNLAICLQPHRLGKLADQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKIL 1412

  Fly  1516 PGVKVIIANPETKGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYART 1580
            |||::|||||||||..||||||||||...||.:||||:||||...:||||::|..|.|..::|||
Zfish  1413 PGVRIIIANPETKGPLGDSHLGEIWVHCAHNGSGYFTVYGDEALQSDHFNSRLSFGDTQTVWART 1477

  Fly  1581 GYLGFLRRTECSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNA 1645
            ||||||||||.:.::.
Zfish  1478 GYLGFLRRTELTDASG------------------------------------------------- 1493

  Fly  1646 NDQELHDAVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNES 1710
               |.|||:|||||:||.:.||||.|||||||.||:|.||.|.|||||.|||||||||||:|:|.
Zfish  1494 ---ERHDALYVVGALDEAMELRGMRYHPIDIETSVIRTHKSIMECAVFPWTNLLVVVVELEGSEQ 1555

  Fly  1711 EALDLVPLVTNTVLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1773
            |||||||||||.|||:|.||||||||||.||:|||||||||||||||||||||||||||||||
Zfish  1556 EALDLVPLVTNAVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995	32/107 (30%)
		ARG80	33..369	CDD:227400	73/368 (20%)
		PRK09192	470..1061	CDD:236403	355/592 (60%)
		Dip2	470..1054	CDD:213273	349/585 (60%)
		AMP-binding	1142..1587	CDD:278902	289/455 (64%)
		AFD_class_I	1159..1762	CDD:302604	373/613 (61%)
dip2ca	XP_009295792.1	DMAP_binding	6..118	CDD:283995	61/208 (29%)
		CaiC	369..960	CDD:223395	365/612 (60%)
		Dip2	393..957	CDD:213273	349/585 (60%)
		AMP-binding	1028..1512	CDD:278902	305/535 (57%)
		AFD_class_I	1047..1607	CDD:302604	372/611 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574076
Domainoid	1	1.000	603	1.000	Domainoid score	I187
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40996
Inparanoid	1	1.050	1718	1.000	Inparanoid score	I70
OMA	1	1.010	-	-		QHG52530
OrthoDB	1	1.010	-	-		D539697at2759
OrthoFinder	1	1.000	-	-		FOG0001187
OrthoInspector	1	1.000	-	-		otm25628
orthoMCL	1	0.900	-	-		OOG6_101035
Panther	1	1.100	-	-	LDO	PTHR22754
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1019
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770