DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and CG6178

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	129/703 - (18%)
Similarity:	233/703 - (33%)	Gaps:	219/703 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1104 ASVMVGNLVQGNRLAEAHGRDVGLAEDCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTL 1168
            :.::.||:|.|..:.|..      |:|.....|.|..    :..:..|..:  |:::...:  ..
  Fly     3 SKLLPGNIVYGGPVTERQ------AQDSRSLGQYILD----KYKSFGDRTV--LVDAVNGV--EY 53

  Fly  1169 TCSELHKRAEKIAALLQERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNT 1233
            :.|.:||...::|.:||:.| ::..|.|.|.....::...|.:..|.:||   |:.|     ||.
  Fly    54 SASFMHKSIVRLAYILQKLG-VKQNDVVGLSSENSVNFALAMFAGLAVGA---TVAP-----LNV 109

  Fly  1234 TLP--TVRMIVDVSKSGIV----LSIQPIIKLLKSRE-----AATSIDPKTWPPILDI-----DD 1282
            |..  .|...:::||..|:    ::|..:.|:....:     .|.|...|.:..|.|:     |:
  Fly   110 TYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDE 174

  Fly  1283 NPKRK--YAGIATVSFDSSAYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVALCL 1345
            ..|.:  :...|....:..:.:..|..|.|...||.:|..:|.:...| ::...:.|...|.|
  Fly   175 KFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDS-QIQPTVIPMEEVTL-- 236

  Fly  1346 DPYCGLGFVMW-------TLIGVYS-GHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIE 1402
                 |..:.|       |||.... |...:.:..:|    ..|:||.:.::||...|....::.
  Fly   237 -----LTVIPWFHAFGCLTLITTACVGARLVYLPKFE----EKLFLSAIEKYRVMMAFMVPPLMV 292

  Fly  1403 LCTKALSNSIPSLKQRNIDLRCVRTCVVV-----AEERPRVQLTQQFCKLFQALGLNTRCVSTSF 1462
            ...|.     |.:.:.::....|..|...     .|::.:.::...|.:  |..||:...:|
  Fly   293 FLAKH-----PIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIR--QGYGLSESTLS--- 347

  Fly  1463 GCRVNPAICVQGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIANPET 1527
                   :.||.....:...|                            |.|..|:...:.:|:|
  Fly   348 -------VLVQNDEFCKPGSV----------------------------GVLKVGIYAKVIDPDT 377

  Fly  1528 KGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTECS 1592
            ....|.:..||:..:......||.   ||         .|....|..:.:..||.:|:.
  Fly   378 GKLLGANERGELCFKGDGIMKGYI---GD---------TKSTQTAIKDGWLHTGDIGYY------ 424

  Fly  1593 QSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVV 1657
                            |.|.|                                        .::|
  Fly   425 ----------------DDDFE----------------------------------------FFIV 433

  Fly  1658 GAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNESEALDLVPLV--- 1719
            ..:.|:|..:|....|.:|| :::..:.||.:.||.             |...|....:||.
  Fly   434 DRIKELIKYKGYQVPPAEIE-ALLLTNDKIKDAAVI-------------GKPDEEAGELPLAFVV 484

  Fly  1720 --TNTVLEDHQLIV-------------GVVVVVDPGVVPINSRGEKQRMHLRD 1757
              .|..|.::::|.             |.|:.||.  :|.|..|:..|..||:
  Fly   485 KQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDE--IPKNPSGKILRRILRE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	89/475 (19%)
		AFD_class_I	1159..1762	CDD:302604	118/648 (18%)
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	122/674 (18%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	116/645 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900