DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and CG11453

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	683	Identity:	127/683 - (18%)
Similarity:	204/683 - (29%)	Gaps:	254/683 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1146 ANTSPDHIIFTLL----NSKGAIAKT----LTCSELHKRAEKIAALLQERGRIEPGDHVALIFPP 1202
            |:.|...|:|..:    ||...|:.|    ||..|....|.:||..|:..| ::..|.|.::...
  Fly    26 ADCSIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRIAQQLKAMG-LKQDDVVGIVGTN 89

  Fly  1203 GLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIV---------LSIQPIIK 1258
            ...|:....|||..|.....:.|...::      |::.:..:::..::         |||  |.:
  Fly    90 TTYLMPVVLGCLLNGTPFHAVSPWQDED------TIKHLFSITRPKLIFCDGKCFQRLSI--IAR 146

  Fly  1259 LLKSREAATSIDPKTWPPILDIDDNPKRKYAGIATVSFDSSAYLDFSVSTCGRLSGVNITHRSLS 1323
            :|||............|.:.|:.:
  Fly   147 ILKSHVYTLKDHRLGMPRVEDLLE----------------------------------------- 170

  Fly  1324 SLCASLKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSILI--------APYEVEANPS 1380
                  ....|||                :|..||:  ..|.|::.|        .|..|..:.|
  Fly   171 ------PTTAELY----------------YVPETLL--LGGDHTVAILCTSGTTGLPKAVCISNS 211

  Fly  1381 LWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERP-----RVQL 1440
            ..|........:|...|:..|:.          |....|:...|......:..:||     .:||
  Fly   212 ACLFDFGFVTGQDVLLSFSTIDW----------SAGMFNMLFSCCHGSTRIITDRPYTPEYMIQL 266

  Fly  1441 T------------QQFCKLFQALGLN------TRCVSTSFG-CRVNPAICVQ----------GAS 1476
            .            ||...|.:...||      .|.||...| |.|...:.:|          |.:
  Fly   267 VEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYVANLLKLQEFLITGQISYGYA 331

  Fly  1477 SAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIANPETKGHCGDSHLGEIWV 1541
            ..|...|..:|...:           |:|:     |:::|||:|.|.: |.....|....|||.|
  Fly   332 LTECGGVAANMGVAK-----------PSSV-----GRIVPGVRVKILD-EAGRSLGHGETGEILV 379

  Fly  1542 QAPHNA---NGYFTIYGDE---TDYNDHFNAKLVTGATSELYARTGYLGFLRRTECSQSASLLDE 1600
               ||.   |||:....:.   .||...|:              ||.:|:.
  Fly   380 ---HNGKVWNGYYANPNESKRMQDYQGWFH--------------TGDMGYF-------------- 413

  Fly  1601 TTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAVDEVIS 1665
                                                        .|:..||    :|...::::.
  Fly   414 --------------------------------------------DNENYLH----IVERKEDLLR 430

  Fly  1666 LRGMNYHPIDIENSVMRCHKKIAECAVFTWTNL-----LVVVVELDGNESEALDLVPLVTNTVLE 1725
            ..|..|.|.:||..:......|..|....|..:     ...||::.|:....:|:|..|...::.
  Fly   431 FHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEYVAKRLVV 495

  Fly  1726 DH-QLIVGVVVVVDPGVVPINSRGEKQRMHLRD 1757
            || ||..||..:.:   :|....|:..|...||
  Fly   496 DHKQLHCGVFFLPE---LPKTGSGKVLRQQARD 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	98/505 (19%)
		AFD_class_I	1159..1762	CDD:302604	123/666 (18%)
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	127/683 (19%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	118/655 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900