DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and CG11391

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_650830.1	Gene:	CG11391 / 42353	FlyBaseID:	FBgn0038732	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	99/497 - (19%)
Similarity:	170/497 - (34%)	Gaps:	155/497 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1131 CER----KPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIE 1191
            |.|    ..:|..|.:.:|........||.:.::...   .||..::.:.|.||...|:::|..:
  Fly    22 CSRHSLYNEELTVGQIIFRQLQRQPQRIFQISHTDNT---RLTRFQMLQNAAKIGCYLRDQGFKK 83

  Fly  1192 PGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPI 1256
            ..|.|.|:......:....||||:.|.      |.|..|.|....|:..:..:::..|:......
  Fly    84 ETDLVGLMARNSTHVGALAYGCLFNGT------PFHAVNPNLEHNTISSLYKITRPRILCCDTAD 142

  Fly  1257 IKLLKSREAA-----TSIDPKTWPPILDIDD----------NPKRKYAGI--------------- 1291
            .:.:|...|:     .:::.|. |.::.:.|          .|.:...|:
  Fly   143 YEKIKDIGASLGALIITVNGKL-PGVISVADILQNPLPDDYEPAQFQRGVDRTMAILCSSGTTGT 206

  Fly  1292 ---ATVS-----FDSSAYL-----DFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVAL 1343
               .|:|     |:..:||     .::.||...|:|: ||..:.:.......::.|::.:.|.
  Fly   207 PKAVTLSNSRKLFEMHSYLGSDDVQYAPSTLDWLTGL-ITLVTAAVFGTVRLISSEMFSTAHF-- 268

  Fly  1344 CLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKAL 1408
             || .|....|.||::.  :.|.::|       ||                         |.|..
  Fly   269 -LD-ICEQHEVSWTIMA--NSHVAML-------AN-------------------------CPKTS 297

  Fly  1409 SNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCK----LFQALGLNTRCVSTSFGCRVNPA 1469
            :..:.|||..   |.....|:|..     ::..|.|..    |..|.||      |..|..|:..
  Fly   298 AQKLRSLKHL---LFAGGHCLVAT-----LKKMQSFLHGSGILRNAYGL------TEVGTLVSYN 348

  Fly  1470 ICVQGASSAESAQVYVDMRALRNNRVALVE--------RGAPNSLCVIESGKLLPGVKVIIANP- 1525
            ...|...::..       |.:.|.||.:|:        :|....||  .:|:...|   .:.||
  Fly   349 YDTQSKPTSVG-------RLMANIRVKIVDSSGQLQGPKGLGEILC--HNGQPWSG---YVGNPL 401

  Fly  1526 ---ETKGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHF 1564
               |.:...|..|.|::         |||    ||    ||:
  Fly   402 ATAEMRDSAGWYHTGDV---------GYF----DE----DHY 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	95/482 (20%)
		AFD_class_I	1159..1762	CDD:302604	92/465 (20%)
CG11391	NP_650830.1	CaiC	24..541	CDD:223395	98/495 (20%)
CG11391	NP_650830.1	AFD_class_I	51..527	CDD:302604	92/468 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900