DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and CG4563

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	126/697 - (18%)
Similarity:	219/697 - (31%)	Gaps:	240/697 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 HGRDVGLAEDCERKPQLITGVLR-WRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALL 1184
            |...||         |::...|| |..|      :..:.:..|.:   ||.:::...|.:||...
  Fly    29 HNTSVG---------QIVFNSLRCWPTN------VIQITDDDGTV---LTNADMLAYATRIALFF 75

  Fly  1185 QERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGI 1249
            :..| :...|.|.:|......::.....|.:...      |.|..|.:.....|:.:..|:|..|
  Fly    76 KSEG-LTQEDRVGIIANSSTFVIPVATACFFQAT------PFHAVNYSREPAIVQGLYSVTKPKI 133

  Fly  1250 VLSIQP---------------IIKLLKSREAATSIDPKTWPPILDIDDNPKRKY---AGIATVSF 1296
            :....|               :|.|....|..|||:....|       :|..|.   |.:|| ..
  Fly   134 MFIDGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKP-------HPAEKIYVPASLAT-GG 190

  Fly  1297 DSSAYLDFSVSTCGRLSGVNITHR---SLSSLCASLKLACELYPSRHVALCLDPYCGLGFVMWTL 1358
            |..|.:..|..|.|....|.::||   |.:|||.|..:   ||.|    ..:|...|...   |:
  Fly   191 DQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCISTDV---LYTS----ATIDWMTGFSI---TV 245

  Fly  1359 IGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLR 1423
            :.:..|...| |:.....|..:|:|  :|:::|
  Fly   246 MNLTCGFTRI-ISRRTFSAETALYL--VSKYKV-------------------------------- 275

  Fly  1424 CVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQV----- 1483
               ||:.:|.              :||..|.|..::||              ...||.::
  Fly   276 ---TCLAMAP--------------WQAYELFTSPLATS--------------EQLESLKIAFVIG 309

  Fly  1484 -YVDMRALRNNRVAL-----------VERGA-----PNSL-CVIESGKLLPGVKVIIANPETKGH 1530
             ::.:..||..:..|           .|.|.     .:|| |.:  |:|.||:::.|.. |....
  Fly   310 GWISLALLRRAQELLPKTYVMFSYGTTETGVVTINIDHSLECSV--GRLAPGMRIKIQG-EDGQQ 371

  Fly  1531 CGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTECSQSA 1595
            .|.:..||:.:.......||.:            |.:.......:.:...|.||:.
  Fly   372 LGVNQTGEVLIDIGLKWEGYLS------------NPEDTATTLQDGWINLGDLGYF--------- 415

  Fly  1596 SLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAV 1660
                         |.|..                                        :|:|...
  Fly   416 -------------DEDNN----------------------------------------LYLVDRK 427

  Fly  1661 DEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLL-----VVVVELDGNESEALDLVPLVT 1720
            .:::..:..:|.|.:||..:....:....|.|.......     .::::.:|.|.....::..|.
  Fly   428 KDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVA 492

  Fly  1721 NTVLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLDPI 1767
            ..|:.|::.:...|:.||.  .|.|:.|:..|...|:.|  ::..||
  Fly   493 QRVVVDYKQLNAGVIFVDK--FPKNANGKVMRSLAREVF--EKTKPI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	96/489 (20%)
		AFD_class_I	1159..1762	CDD:302604	116/651 (18%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	124/691 (18%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	113/644 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900