DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and CG17999

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	115/552 - (20%)
Similarity:	207/552 - (37%)	Gaps:	126/552 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1114 GNRLAEAHGRDVGLAEDCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAE 1178
            |.|..:.:|.::.|.|       :|..||:..|:.     :..:.::.|   :.||.::|.:::.
  Fly    16 GPRGKDFYGPEMTLGE-------VIMRVLQINADQ-----VMQICDTTG---QELTGAQLAQQSA 65

  Fly  1179 KIAALLQERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVD 1243
            :||...:..| :..||.|.:.......|.......|..|   |.|.|.||:   .|..||:.:.|
  Fly    66 RIAQAFKRLG-LRRGDVVGISANNSTYLTSVIIAALLRG---IPINPLHPE---FTEETVKYMYD 123

  Fly  1244 VSKSGIVLSIQPIIKLLKSREAATSIDPKTWPP------------ILDI-------DDNPKRKYA 1289
            :::..::........::|      :::.|...|            :|||       |......|.
  Fly   124 ITEPKVIFCDVENYHIIK------TVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYV 182

  Fly  1290 GIATVSFDSSAYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVALCLDPYCGLGFV 1354
            ....:..|.:|::..|..|.|...||..:||||...|.:    ...|....|.|...|...:...
  Fly   183 PCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRSLLCNCKN----PNTYTRDSVLLSFSPLYWISGT 243

  Fly  1355 MWTLIGVYSGHHSILI-APYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQR 1418
            :..|..:.:|...|:. .||.||    ..|..:::|:|...|.:...|.|.:|. .:.:..||.:
  Fly   244 IILLASLLNGCRRIITNRPYSVE----YLLQLVARHKVTFLFLASHQIALLSKH-DSDVMELKAQ 303

  Fly  1419 NIDLRCVRTCVVVAEERPRVQLTQQFC-KLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQ 1482
               |:.:|..:....     ::.:..| ::::.:| |.|.| ..:|..
  Fly   304 ---LQSIRVLIGAGS-----KVCKAVCRRMYELIG-NQRFV-VGYGLS----------------- 341

  Fly  1483 VYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIANPETKGHCGDSHLGEIWVQAPHNA 1547
               :|..|..|      .|.|.. |   .||::..|::.:.: :.|...|.:.:|.|:.:.....
  Fly   342 ---EMGGLSKN------VGGPVG-C---EGKVMRNVELRVLD-KLKMPLGINEVGIIYARLRFKW 392

  Fly  1548 NGYFTIYGDETDYNDHFNAKLVTGATSE--LYARTGYLGFLRRTECSQSASLLDETTPSVASRDS 1610
            .||:.            |.:....|.|.  ::.|||.:|:|      .|...|     .:.:||:
  Fly   393 AGYYR------------NPEATRRALSSDGMWFRTGDIGYL------DSEGYL-----YIQTRDT 434

  Fly  1611 DTESLNS--ISQLQLNFSNVSLGGNSEHSLVG 1640
            |....|:  |...|:....:.|.|.||..:.|
  Fly   435 DVFKFNNFQIYPEQIEEFILRLPGVSEACVFG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	94/467 (20%)
		AFD_class_I	1159..1762	CDD:302604	106/507 (21%)
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	112/543 (21%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	107/523 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810