DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and acs-2

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_506869.1	Gene:	acs-2 / 3565680	WormBaseID:	WBGene00009221	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	737	Identity:	142/737 - (19%)
Similarity:	224/737 - (30%)	Gaps:	267/737 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1049 RRFLEGSLHPANVLMCPHTC--VTNLPKPRELHQGVQTAAKLSSSSGCGITDTGVGPASVMVGNL 1111
            |||       |:||...|..  .:|:|.....|....:..:..::|...      |.:::.:.|.
Worm     8 RRF-------AHVLTSTHAAPSTSNIPTTDSHHLTHPSVHRQHTNSYIH------GTSNIPLRNE 59

  Fly  1112 VQGNRLAEAHGRDVGLAEDCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKR 1176
            ..|..|...          .||.|             ..:..:|    ||..|.||.  .|.:..
Worm    60 TLGQTLRNT----------TERVP-------------DKEFCVF----SKYPIRKTY--EEFYHD 95

  Fly  1177 AEKIAALLQERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRP---------------- 1225
            ..::||.|...| :|.||.|.:..|...:.:...|.|.:.|.|.:.:.|
Worm    96 VRQMAASLYTLG-LEKGDRVGVWGPNYYEWVVLQYACAFAGVIQVNVNPHYLHEELRFVMRKTGM 159

  Fly  1226 ---------PHPQNLNTTL---------------------PTVRMIV----DVSKSGIVLSIQPI 1256
                     .|...::|.|                     |.:|.||    ||...|..: ...:
Worm   160 KVLFAPKRHKHSNYVHTMLEAMPEMRRGQPGVGHIKSHDIPELRHIVLYGDDVPVHGAWV-YSDL 223

  Fly  1257 IKLLKSREAA--TSIDPKTWPPILDIDDNPKRKYAGIATVSFDSSAYLDFSVSTCGRLSGVNITH 1319
            |....|.|.|  ..:|.|..|                     |....:.|:..|.|...|..:||
Worm   224 IHAAGSAERAKLEDMDRKLRP---------------------DEPVNMQFTSGTTGHPKGATLTH 267

  Fly  1320 RSL--SSLCASLKLACELYPSRHVALCL-DPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSL 1381
            ..|  ::..|.::|..:....|   :|: :|       ::...|
Worm   268 FGLNNNAYFAGIRLGWDREDHR---ICIPNP-------LYHCFG--------------------- 301

  Fly  1382 WLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCK 1446
                          |:.|||.......:...||......|
Worm   302 --------------CAVGVINAVNHGQTVVFPSKSYHVPD------------------------- 327

  Fly  1447 LFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIES 1511
            :|:|: .|.:| :|.||   .|.:.:....|....|  .|:.:||...:.    |||..:.:.|
Worm   328 IFEAI-QNEKC-TTMFG---TPTMFIDVLKSPLMKQ--FDISSLRGGVIG----GAPCPMALCE- 380

  Fly  1512 GKLLPGVK-----VIIANPETKGHCGDSHL-----------GEIWVQAPHNANGYFTIYGDETDY 1560
             |::..::     ||..:.||......|.|           |.:   .||          .|...
Worm   381 -KMVKEMRMTDFSVIYGSTETSPLVTMSELHVDPFERIKSVGSV---MPH----------QELAI 431

  Fly  1561 NDHFNAKLVTGATSELYARTGY---LGFLRRTECSQSASLLDETTPSVASRDSDTESLNSISQLQ 1622
            .|.|...:.|||..||::| ||   ||:....:.:..|...|....|     .||.::|
Worm   432 VDEFGVPVPTGAKGELWSR-GYSTMLGYWADHDKTNLAITRDRWYKS-----GDTATMN------ 484

  Fly  1623 LNFSNVSLGGNSEHSLVGGASNAN----DQELHDAVY-----VVGAVDE--------VISLRGMN 1670
             ....:::.|.:...:|.|..|..    :|.||...|     |||..|:        .:.||..:
Worm   485 -EDGTINIVGRTRDMIVKGGENVYPTEIEQFLHKLDYVADAHVVGVPDDRYGENICAWVRLRVED 548

  Fly  1671 YHPIDIENSVMRCHKKIAECAV 1692
            ...|..|:....|.:.:|...|
Worm   549 EGKITAEHIKKACKRGMAHYKV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403	4/11 (36%)
		Dip2	470..1054	CDD:213273	3/4 (75%)
		AMP-binding	1142..1587	CDD:278902	99/518 (19%)
		AFD_class_I	1159..1762	CDD:302604	123/625 (20%)
acs-2	NP_506869.1	PRK08315	46..609	CDD:236236	132/692 (19%)
acs-2	NP_506869.1	FACL_like_2	244..595	CDD:213284	87/457 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900