DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and Acsf2

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_722502.1	Gene:	Acsf2 / 264895	MGIID:	2388287	Length:	615	Species:	Mus musculus

Alignment Length:	763	Identity:	142/763 - (18%)
Similarity:	246/763 - (32%)	Gaps:	242/763 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1068 CVTNLPK--PRELHQGVQTAAKLSS----SSGCGITDTGVGPASVMVGNL--VQGNRLAEAHGRD 1124
            |:.:|..  ||.|....:..:||.|    |||. :..|...|    :|.|  :||:..:......
Mouse    14 CIASLGARGPRTLLSRPRPNSKLQSVRALSSGM-VNCTNPLP----IGGLSYIQGHTDSHLVNTT 73

  Fly  1125 VGLAEDCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGR 1189
            ||   :|          |...|...||.....:|:..    ..|..::|.:..:|.|:.|...|
Mouse    74 VG---EC----------LDATAQRFPDREALVILHEN----IRLNFAQLKEEVDKAASGLLSIG- 120

  Fly  1190 IEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQ 1254
            :..||.:.:..|.....:.........|.|.:::.|.:.   ::.|..|  :..|...|||...|
Mouse   121 LRKGDRLGMWGPNSYAWVLIQLATAQAGIILVSVNPAYQ---SSELEYV--LRKVGCKGIVFPKQ 180

  Fly  1255 -------PIIK------------LLKSRE-----AATSIDPKTWPPILDIDD--NPKRKYAGIAT 1293
                   .|:|            .|||..     ...|:|... |..|.:||  ....|...:|.
Mouse   181 FKTQQYYDILKQVCPELEKAQPGALKSERLPDLTTVISVDAPL-PGTLLLDDIVAAGGKEQNLAQ 244

  Fly  1294 VSFDS---SAY----LDFSVSTCGRLSGVNITHRSL--SSLCASLKLACELYPSRHVALCLDP-- 1347
            :.::.   |.|    :.|:..|.|...|..::|.::  :|:....:|......:..:.|.|..
Mouse   245 LRYNQRFLSCYDPINIQFTSGTTGNPKGATLSHHNIVNNSMLIGQRLKMPTKTAEELRLVLPSPL 309

  Fly  1348 YCGLGFVMWTLIGVYSGHHSILIAP-----YEVEA-----------NPSLWLSTLSQHRVRDTFC 1396
            |..||.|..|::.:..|...:|.:|     ..:||           .|::::..|:|    ..|.
Mouse   310 YHCLGSVGGTMVSMMHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQ----PDFS 370

  Fly  1397 SYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQAL--GLNTRCVS 1459
            ||                      |...:|..|:.....|.        :|.:|:  .:|.:.:.
Mouse   371 SY----------------------DFTSIRGGVIAGSPAPP--------ELIRAIINKMNMKELV 405

  Fly  1460 TSFGCRVNPAICVQGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIAN 1524
            ..:|...|..:                  ...|.....:|:.|.:      .|:::|..:..|.|
Mouse   406 VVYGTTENSPV------------------TFMNFPEDTLEQKAGS------VGRIMPHTEAQIVN 446

  Fly  1525 PETKGHCGDSHL-GEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRR 1588
            .|| |...:.:: ||::::......||   :|:.        .|.......:.:.|||
Mouse   447 VET-GELTNLNVPGELYIRGYCVMQGY---WGEP--------QKTFETVGQDKWYRTG------- 492

  Fly  1589 TECSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHD- 1652
                 ..:|:||.                      .|..:.  |.|:..::.|..|....||.|
Mouse   493 -----DIALMDEQ----------------------GFCKIV--GRSKDMIIRGGENIYPAELEDF 528

  Fly  1653 --------AVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNE 1709
                    ...|||..||                   |..::|..|            :.|...|
Mouse   529 FLKHPQVQEAQVVGVKDE-------------------RMGEEICAC------------IRLKSGE 562

  Fly  1710 SEALDLVPLVTNTVLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRD 1757
            :...:.:.......: .|..|...:|.|:.  .|:...|:.|:..||:
Mouse   563 TTTAEEIKAFCKGKI-SHFKIPRYIVFVEG--YPLTISGKIQKFKLRE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	92/500 (18%)
		AFD_class_I	1159..1762	CDD:302604	117/664 (18%)
Acsf2	NP_722502.1	PRK08315	57..615	CDD:236236	128/715 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900