Protein Alignment DIP2 and Dip2b

DIOPT Version :10

• Sequence 1: NP_612019.2
• Gene: DIP2 / 252479
• FlyBaseID: FBgn0024806
• Length: 1773
• Species: Drosophila melanogaster
• Sequence 2: XP_011243931.1
• Gene: Dip2b / 239667
• MGIID: 2145977
• Length: 1619
• Species: Mus musculus
• Alignment Length: 1841
• Identity: 897/1841 - (48%)
• Similarity: 1141/1841 - (61%)
• Gaps: 307/1841 - (16%)

  Fly     5 ASLPGYVREKLAELDLELSEGDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNS 69
            |:||..||.:||||:|||||||||||||||||:|||.|:
Mouse    14 AALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPY-------------------------- 52

  Fly    70 TNHGNINNDGVIVSSEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAPGYENM 134
                                        |.|.:.:..|.   |...:.:.||.:....||...:.
Mouse    53 ----------------------------SPQTQETDSIG---QKERNQTPAPTAAQTSAPSKYHR 86

  Fly   135 RPQGGAVGDPGYQNTREPSAFQNQQSTNNSQHRQRRTQRKVTHNEKRYHSEVRQEAVQQALAALK 199
            ...|||                                     .::||.|::..||||.|||..|
Mouse    87 SRSGGA-------------------------------------RDERYRSDIHTEAVQAALAKHK 114

  Fly   200 GRPKPSLPMPSKRTSVLNRSPGCNDELDSSTDDESIPEETISPDKEYNYPRDH------ISNSIL 258
             ..|.:||||:||.|...:||.          |...|.:|.|..::....|..      :..|:.
Mouse   115 -EQKMALPMPTKRRSTFVQSPA----------DACTPPDTSSASEDEGSLRRQAALSAALQQSLQ 168

  Fly   259 PPEPIIKPPIRESSMGSQQHARTDVKQNQITNQKYT-APNSAPERRPPQNLPPLPTS-------- 314
            ..|..|...|:.||..|.  |.:.:...::.....: |...|..|....:.||..|:
Mouse   169 NAESWINRSIQGSSTSSS--ASSTLSHGEVKGTSGSLADVFANTRIENVSAPPDVTATTSSSSSS 231

  Fly   315 -EPLSSDYPPIAYKRENDFSDKAFKQKQYNAPDITQFNNAHRAADRVTRYVNVSQNELNETDANG 378
             .|.:.|.||....:                       ..|:.::|         :.|.:| |:|
Mouse   232 LRPANIDLPPSGIVK-----------------------GMHKGSNR---------SSLMDT-ADG 263

  Fly   379 ---KWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPNAPKPEGSTMTPVQGEQLS 440
               ..:||.||||||||||||||.||.||:.|:..|:.......|||.|||||..||||:||.|.
Mouse   264 VPVNSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEGIPQPDPNQPKPEGRQMTPVKGEPLG 328

  Fly   441 IPAGLPRTLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLLSRAQKIAHALSTKIFSKGPE 505
            :....|..||.||||:|:...|.|..|.||..||...|||||||.||:.|:|:.|..|:.:|  .
Mouse   329 VICNWPPALESALQRWGSTQAKCPCLTGLDVTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTK--N 391

  Fly   506 QVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPPQQVGFLLSSCGITVA 570
            :..||||||||||||||||:.|:.|:|||:...::|:|||:||:..|...||:||||.||||.:|
Mouse   392 EPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALA 456

  Fly   571 LTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEFNVGNLRADDSAAAYIEYTTD 633
            ||||.||||||| |..|||.:.||||||:|.||:  :|.||||::. .::....:..|||||.|.
Mouse   457 LTSEICLKGLPK-TQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQ-PHISPAGTEPAYIEYKTS 519

  Fly   634 KEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREVGLWHSVLTSVLNGMHVIFIPY 698
            ||||||||||:|.||::.|:||:.||:|:||||:|.|||||::.||||.:..:|:|.||.|.:||
Mouse   520 KEGSVMGVTVSRLAMLSQCQALSQACNYSEGETVVNVLDFKKDAGLWHGMFANVMNKMHTISVPY 584

  Fly   699 ALMKLRPSSWMQLITKHRASCCLVKSRDLHWGLLATKDHKDISLSSLRMLLVADGANPWSLSSCD 763
            ::||..|.||:|.:..|:|...|||.|||||.::|.:|.:|:||||||||:|.|||||||:||||
Mouse   585 SVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCD 649

  Fly   764 QFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSA--TGRGVLSMAALSHGVVRVD 826
            .|||:||:.||:.:||||||:|:|..||::||||      .|.|  .||.:|||..||:||:||:
Mouse   650 AFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPG------VPGAPLPGRAILSMNGLSYGVIRVN 708

  Fly   827 SEDSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEICVTSGSTSASYFGLDGMTNSTFK 891
            :||..::||:||.|.|||...|.:|:.:|.|.||:||::|||||:|.:....||||.|:|.:||:
Mouse   709 TEDKNSALTVQDVGHVMPGGMMCIVKPDGLPQLCRTDEIGEICVSSRTGGMMYFGLAGVTKNTFE 773

  Fly   892 VQPLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKHNAD 956
            |.|              |.....|:|:..::|||||||:|||.||||.|..|||:.|:||:||||
Mouse   774 VIP--------------VTSSGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNAD 824

  Fly   957 DIIATVLAVEPMRFIYRG---------------------------------------------RI 976
            ||:||.||||.::.:|||                                             ||
Mouse   825 DIVATGLAVESIKTVYRGRHTGLLAVPQTCQARPYLRTFPLSVPSVRNPLPPDLRVARVLTSFRI 889

  Fly   977 AVFSIKVLRDERVCVIAEQRPDCSEEESFQWMSRVLQAVDSIHQVGIYCLALVPPNHLPKTPLGG 1041
            ||||:.|..|||:.|:||||||.|||:|||||||||||:|||||||:|||||||.|.||||||||
Mouse   890 AVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGG 954

  Fly  1042 IHLCEARRRFLEGSLHPANVLMCPHTCVTNLPKPRELHQGVQTAAKLSSSSGCGITDTGVGPASV 1106
            ||:.:.::.||||||||.|:|||||||||||||||:                   ...|||||||
Mouse   955 IHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQ-------------------KQPGVGPASV 1000

  Fly  1107 MVGNLVQGNRLAEAHGRDVGLAE--DCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLT 1169
            ||||||.|.|:|:|.|||:|..|  |..||.|.:..:|:|||..:|||::|.|||:||....|.:
Mouse  1001 MVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTAS 1065

  Fly  1170 CSELHKRAEKIAALLQERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTT 1234
            |.:||||||:||::|.::|.:..||:|.|::|||::|:.|||||||.|.||:|:||||.|||..|
Mouse  1066 CLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTAT 1130

  Fly  1235 LPTVRMIVDVSKSGIVLSIQPIIKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGI-ATVSFDS 1298
            ||||||:|||||:..||:.|.:::||||||||.::|.||||.|:|.||.|:::...: ...:.:.
Mouse  1131 LPTVRMVVDVSKAACVLTTQTLMRLLKSREAAAAVDVKTWPAIIDTDDLPRKRLPQLYKPPTPEM 1195

  Fly  1299 SAYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYS 1363
            .|||||||||.|.|:||.::|.::::||.::||.||||.||.:|:||||||||||.:|.|..|||
Mouse  1196 LAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYS 1260

  Fly  1364 GHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLRCVRTC 1428
            ||.|:||.|.|:|.|..|||:|::|:::|||||||.|:|||||.|.|.:..||.|.|:|.|:|||
Mouse  1261 GHQSVLIPPMELENNLFLWLATVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCIRTC 1325

  Fly  1429 VVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQVYVDMRALRNN 1493
            ||||||||||.|.|.|.|||:.:||:.|.|||:||.|||.|||:||.|..:...||||:::||::
Mouse  1326 VVVAEERPRVSLQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHD 1390

  Fly  1494 RVALVERGAPNSLCVIESGKLLPGVKVIIANPETKGHCGDSHLGEIWVQAPHNANGYFTIYGDET 1558
            ||.|||||||.||.:.||||:||||||:|.||||||..||||||||||.:||.|:||:|||..||
Mouse  1391 RVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSET 1455

  Fly  1559 DYNDHFNAKLVTG-ATSELYARTGYLGFLRRTECSQSASLLDETTPSVASRDSDTESLNSISQLQ 1622
            ...||||.:|..| |...|:||||||||:||||.:.:..
Mouse  1456 LQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATG-------------------------- 1494

  Fly  1623 LNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKI 1687
                                      |.|||:|||||:||.:.|||:.|||||||.||.|.|:.|
Mouse  1495 --------------------------ERHDALYVVGALDETLELRGLRYHPIDIETSVSRVHRSI 1533

  Fly  1688 AECAVFTWTNLLVVVVELDGNESEALDLVPLVTNTVLEDHQLIVGVVVVVDPGVVPINSRGEKQR 1752
            ||||||||||||||||||.|:|.|||||||||||.|||:|.||||||||||||||||||||||||
Mouse  1534 AECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVVPINSRGEKQR 1598

  Fly  1753 MHLRDGFLADQLDPIYVAYNM 1773
            |||||.|||||||||||||||
Mouse  1599 MHLRDSFLADQLDPIYVAYNM 1619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:368923	34/109 (31%)
		ARG80	33..369	CDD:227400	65/351 (19%)
		Dip2	465..1061	CDD:341231	343/644 (53%)
		Dip2	1154..1769	CDD:341231	361/616 (59%)
Dip2b	XP_011243931.1	DMAP_binding	14..130	CDD:368923	60/210 (29%)
		Dip2	353..974	CDD:341231	343/644 (53%)
		Dip2	1050..1615	CDD:341231	361/616 (59%)