Protein Alignment DIP2 and DIP2A

DIOPT Version :10

• Sequence 1: NP_612019.2
• Gene: DIP2 / 252479
• FlyBaseID: FBgn0024806
• Length: 1773
• Species: Drosophila melanogaster
• Sequence 2: XP_047296663.1
• Gene: DIP2A / 23181
• HGNCID: 17217
• Length: 1616
• Species: Homo sapiens
• Alignment Length: 1828
• Identity: 914/1828 - (50%)
• Similarity: 1157/1828 - (63%)
• Gaps: 281/1828 - (15%)

  Fly     5 ASLPGYVREKLAELDLELSEGDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNS 69
            |.||..|||.||||:|||||||||||||||||||||..::...:|..
Human    11 APLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGID------------------ 57

  Fly    70 TNHGNINNDGVIVSSEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAPGYENM 134
                                    |||.:..:                ...|....|.||..:..
Human    58 ------------------------PSLQAENR----------------IPGPSQTTAAAPKQQKS 82

  Fly   135 RPQGGAVGDPGYQNTREPSAF---------QNQ----QSTNNSQHRQRRTQRKVTHNEKRYHSEV 186
            ||.  |..|..:::......|         :|:    |.:|.|...|.              .:|
Human    83 RPT--ASRDERFRSANIQPMFIWLLLVWLLRNKFIWTQDSNKSYTLQL--------------VDV 131

  Fly   187 RQEAVQQALAALKGRPKPSLPMPSKRTSVLNRSPGCNDELDSSTDDESIPEETISPDKEYNYPRD 251
            ..||||.|||..|.|   .:||||||.|||         :.||.:..: |.:|.|..::
Human   132 HTEAVQAALAKYKER---KMPMPSKRRSVL---------VHSSVETYT-PPDTSSASED------ 177

  Fly   252 HISNSILPPEPIIKPPIRESSMGSQQHARTD-----VKQNQITNQKYTAPNSAPERRPPQNLPPL 311
                     |..::.|.|.:|...|.|:..:     |.|...|:...::.:|.|..|
Human   178 ---------EGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGR-------- 225

  Fly   312 PTSEPLSSDYPPIA----------------YKRENDFSDKAFKQKQYNAPDITQFNNAHRAADRV 360
            ||:.|.::..|..|                :....|.:....:...:..|.:....:..|..
Human   226 PTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGC--- 287

  Fly   361 TRYVNVSQNELNETDANG---KWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPN 422
                   ...:.|| |:|   ..:||:||||||||||||||.||.||:.| |.|..:.....|||
Human   288 -------SGSMLET-ADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVD-DFEELLEVQQPDPN 343

  Fly   423 APKPEGSTMTPVQGEQLSIPAGLPR--TLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLL 485
            .||||||..:.::||.|:  ||:||  :|...|||:||...|||..|.||..||...|||||||.
Human   344 QPKPEGSETSVLRGEPLT--AGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLW 406

  Fly   486 SRAQKIAHALSTKIFSKGPEQVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSS 550
            ||:.|:|:.|..|:.||  .:..||||||||||:||:||:.|:.|:|||:...|||:|||:||:.
Human   407 SRSLKLAYTLLNKLTSK--NEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTR 469

  Fly   551 SDTPPQQVGFLLSSCGITVALTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEF 613
            .|...|||||||.|||:.:|||::||.|||||: .|||:|..||||.|.|.|.:  ||.||||::
Human   470 KDAGSQQVGFLLGSCGVFLALTTDACQKGLPKA-QTGEVAAFKGWPPLSWLVIDGKHLAKPPKDW 533

  Fly   614 NVGNLRAD-DSAAAYIEYTTDKEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREV 677
            :  .|..| .:..|||||.|.||||.:||||:.|:::..|||||.||.|:|.||:..||||||:.
Human   534 H--PLAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDA 596

  Fly   678 GLWHSVLTSVLNGMHVIFIPYALMKLRPSSWMQLITKHRASCCLVKSRDLHWGLLATKDHKDISL 742
            ||||.|||||:|.|||:.:||||||..|.||:|.:..::|...||||||:||.|||.:..:|:||
Human   597 GLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYKARAALVKSRDMHWSLLAQRGQRDVSL 661

  Fly   743 SSLRMLLVADGANPWSLSSCDQFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSA 807
            ||||||:|||||||||:||||.||:|||::|||.:.|||||||.|..||::|||        |..
Human   662 SSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRP--------PDL 718

  Fly   808 TG----RGVLSMAALSHGVVRVDSEDSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEI 868
            .|    :.||||..||:||:|||:|:.|:.||:||.|||||.|.:.||:.||.|.|||||:||||
Human   719 GGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLCKTDEVGEI 783

  Fly   869 CVTSGSTSASYFGLDGMTNSTFKVQPLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPG 933
            ||:|.:|..:|:||.|:|.:.|:..|:.         .|...|..:|     :.|:|||||:||.
Human   784 CVSSSATGTAYYGLLGITKNVFEAVPVT---------TGGAPIFDRP-----FTRTGLLGFIGPD 834

  Fly   934 GLVFVCGSRDGLMTVTGRKHNADDIIATVLAVEPMRFIYRGRIAVFSIKVLRDERVCVIAEQRPD 998
            .|||:.|..||||....|:|||||::||.||||||:|:|||||||||:.||.|:|:.::||||||
Human   835 NLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPD 899

  Fly   999 CSEEESFQWMSRVLQAVDSIHQVGIYCLALVPPNHLPKTPLGGIHLCEARRRFLEGSLHPANVLM 1063
            .|||:|||||||||||:|||||||:|||||||.|.|||.||||||:.|.::|||||:|||.||||
Human   900 ASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLM 964

  Fly  1064 CPHTCVTNLPKPRELHQGVQTAAKLSSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVGLA 1128
            |||||||||||||:                   ....|||||::|||||.|.|:|:|.||::...
Human   965 CPHTCVTNLPKPRQ-------------------KQPEVGPASMIVGNLVAGKRIAQASGRELAHL 1010

  Fly  1129 EDCE--RKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIE 1191
            ||.:  ||...:..||:|||:|:|||.:|.|||:||.:..|.||.:||||||::||.|.|:||:.
Human  1011 EDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCVQLHKRAERVAAALMEKGRLS 1075

  Fly  1192 PGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPI 1256
            .||||||::|||:||:.|||||||.|.:|:|:||||||||.||||||:|||:||||..||:.|.:
Human  1076 VGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLTTQAV 1140

  Fly  1257 IKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGI-ATVSFDSSAYLDFSVSTCGRLSGVNITHR 1320
            .:||:|:|||.::|.:|||.|||.||.||:|.|.: ...|.|..|||||||||.|.|:||.::|.
Human  1141 TRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSPDVLAYLDFSVSTTGILAGVKMSHA 1205

  Fly  1321 SLSSLCASLKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLST 1385
            :.|:||.|:||.|||||||.:|:||||||||||.:|.|..|||||.|:|:.|.|:|:|.|||||.
Human  1206 ATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSA 1270

  Fly  1386 LSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQA 1450
            :||::.|.|||||.|:|:|||.|......|:.:.::|.|||||:||||||||:.|||.|.|||:.
Human  1271 VSQYKARVTFCSYSVMEMCTKGLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKD 1335

  Fly  1451 LGLNTRCVSTSFGCRVNPAICV----------QGASSAESAQVYVDMRALRNNRVALVERGAPNS 1505
            |||..|.|||:||||||.|||:          ||.:..:...|||||||||::||.|||||:|:|
Human  1336 LGLPARAVSTTFGCRVNVAICLQPNRLGKLAEQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHS 1400

  Fly  1506 LCVIESGKLLPGVKVIIANPETKGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVT 1570
            |.::||||:|||||||||:.||||..||||||||||.:||||.||:|:||:|..:.|||:|:|..
Human  1401 LPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSF 1465

  Fly  1571 GATSELYARTGYLGFLRRTECSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSE 1635
            |.|..::|||||||||||||.:.::                                   ||.
Human  1466 GDTQTIWARTGYLGFLRRTELTDAS-----------------------------------GGR-- 1493

  Fly  1636 HSLVGGASNANDQELHDAVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLV 1700
                           |||:||||::||.:.||||.|||||||.||:|.|:.||||||||||||||
Human  1494 ---------------HDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLV 1543

  Fly  1701 VVVELDGNESEALDLVPLVTNTVLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLD 1765
            |||||||.|.:|||||.||||.|||:|.|:|||||:|||||:|||||||||||||||||||||||
Human  1544 VVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLD 1608

  Fly  1766 PIYVAYNM 1773
            ||||||||
Human  1609 PIYVAYNM 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:368923	35/109 (32%)
		ARG80	33..369	CDD:227400	70/369 (19%)
		Dip2	465..1061	CDD:341231	347/602 (58%)
		Dip2	1154..1769	CDD:341231	370/625 (59%)
DIP2A	XP_047296663.1	DMAP_binding	10..158	CDD:368923	66/223 (30%)
		Dip2	386..962	CDD:341231	347/602 (58%)
		Dip2	1038..1612	CDD:341231	370/625 (59%)