DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and ACSF3

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	XP_005256350.1	Gene:	ACSF3 / 197322	HGNCID:	27288	Length:	610	Species:	Homo sapiens

Alignment Length:	729	Identity:	149/729 - (20%)
Similarity:	235/729 - (32%)	Gaps:	251/729 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1063 MCPHTCVTNLPKPRELHQGVQTAAKLSSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVGL 1127
            |.||..:|.    |.|              ||.:...                |||.|..|..||
Human     1 MLPHVVLTF----RRL--------------GCALASC----------------RLAPARHRGSGL 31

  Fly  1128 AEDC-----ERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQER 1187
            ....     :|...:.|     ||....|.|  .|::..|    ..|..||:.|:.:::   ||.
Human    32 LHTAPVARSDRSAPVFT-----RALAFGDRI--ALVDQHG----RHTYRELYSRSLRLS---QEI 82

  Fly  1188 GRI---EPGD----HVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVS 1245
            .|:   ..||    .|:.:.......:.|.:.....|.:.:.:...||      ...:..::..|
Human    83 CRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLYRKHP------AAQLEYVICDS 141

  Fly  1246 KSGIVLSIQPIIKLLKS--REAATSIDPKTWPPILDIDDNPKRKYAGI----ATVSF------DS 1298
            :|.:||:.|..::||..  |:....:.|.| |.|          |.|.    |.|..      :.
Human   142 QSSVVLASQEYLELLSPVVRKLGVPLLPLT-PAI----------YTGAVEEPAEVPVPEQGWRNK 195

  Fly  1299 SAYLDFSVSTCGRLSGVNITHRSLSSLCASL--KLACELYPSRHVALCLDPYCGLGFVMWT---- 1357
            .|.:.::..|.||..||..||:::.::...|  |.|                       ||
Human   196 GAMIIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWA-----------------------WTKDDV 237

  Fly  1358 LIGVYSGHH-----SILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQ 1417
            ::.|...||     :.|:.|..|.|. .:.:...|..:|.:.|            ||:..|.:
Human   238 ILHVLPLHHVHGVVNALLCPLWVGAT-CVMMPEFSPQQVWEKF------------LSSETPRI-- 287

  Fly  1418 RNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQ 1482
             |: ...|.|......|......||...:.|      .|.|     |.....:.|.| |:|....
Human   288 -NV-FMAVPTIYTKLMEYYDRHFTQPHAQDF------LRAV-----CEEKIRLMVSG-SAALPLP 338

  Fly  1483 VYVDMRALRNNRVALVERGAPNSLCVIESGKL-------------LPGVKVIIA--NPETKGHCG 1532
            |....:.:..:  .|:||.....:.:..||.|             ||||:|.|.  ||:.:. |.
Human   339 VLEKWKNITGH--TLLERYGMTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREA-CS 400

  Fly  1533 DSHLGEIWVQAPHNANGYFTIY--GDE--TDYNDHFNAKLVTGATSELYAR--TGYLGFLRRTEC 1591
                              :||:  |||  |.....|..|     ..||..|  :.:..:..:.|.
Human   401 ------------------YTIHAEGDERGTKVTPGFEEK-----EGELLVRGPSVFREYWNKPEE 442

  Fly  1592 SQSASLLD---ETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDA 1653
            ::||..||   :|..:|..:|                        .::.:.|..|
Human   443 TKSAFTLDGWFKTGDTVVFKD------------------------GQYWIRGRTS---------- 473

  Fly  1654 VYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAV-----FTWTNLLVVVVELDGNESEAL 1713
                  || :|...|.....:::|..:: .|..|.:.||     .||...:..||.|  .|..:|
Human   474 ------VD-IIKTGGYKVSALEVEWHLL-AHPSITDVAVIGVPDMTWGQRVTAVVTL--REGHSL 528

  Fly  1714 DLVPLVTNTVLEDH 1727
            ....|.....|::|
Human   529 SHRELKEWARLKEH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	103/495 (21%)
		AFD_class_I	1159..1762	CDD:302604	127/628 (20%)
ACSF3	XP_005256350.1	MCS	55..546	CDD:341264	130/636 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900