DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP2 and acs-7

DIOPT Version :9

Sequence 1:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster
Sequence 2:	NP_495979.1	Gene:	acs-7 / 174472	WormBaseID:	WBGene00007228	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	121/688 - (17%)
Similarity:	232/688 - (33%)	Gaps:	206/688 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 HGRDVGLAEDCERKPQLITGVL--RWRAN--TSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIA 1181
            ||      |..|...:.:..||  |::.:  ..||::.|....::.   .:|...:|.|:..:|:
Worm     4 HG------EQLENHDKPVHEVLLERFKVHQEKDPDNVAFVTAENED---DSLGFQQLGKKVLQIS 59

  Fly  1182 ALLQERGRIEPGDHVALIFPPGLDLLCAF--YGCL--YLGAIPITIRPPHPQNLNTTLPTVRMIV 1242
            ....|.| .:.||    :|     ||.::  :.|.  .|||....:......:..|:......|.
Worm    60 EWFVENG-YKKGD----VF-----LLASYNNWRCFAAALGAWRAGLIVSAAASQFTSFEMNYQIE 114

  Fly  1243 DVSKSGIVL-------SIQPIIKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGIATVSFDSS- 1299
            | |:|.::|       .:|...|.||..:...||......|::..|....|....:.....|..
Worm   115 D-SQSQVILVDKHTLPVVQEACKNLKFVKQIISISANPPSPVIKFDVLTSRLVRNLKMPLIDPKN 178

  Fly  1300 --AYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVALCLDP-------------YC 1349
              .:|.:|..|.|:..||.|:|.:.|.:   |:.:...:.:...|:.|.|             |.
Worm   179 DIVFLPYSSGTTGKPKGVMISHLNFSMM---LESSLRFFDANAKAIGLPPDFVLPYDLHFLPMYH 240

  Fly  1350 GLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPS 1414
            .:| :..||:..|.|...|:...:::|    |.|..:.::.:.       |:.|        :|:
Worm   241 AMG-MFRTLLTSYRGTTQIMFTKFDME----LMLKNIEKYSIM-------VLSL--------VPA 285

  Fly  1415 LKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAE 1479
            :..|.::                       ..|.|...::: .||.:.|....|.     ::|.:
Worm   286 IAVRMLN-----------------------SPLLQKYDVSS-LVSVTVGSAPFPE-----SASKK 321

  Fly  1480 SAQVYVDMRALRNNRVA-------LVERGAPNSLCVIESGKLLPGVKVIIANPETKGHCGDSHLG 1537
            ..|:..::..::...:.       |...|:|:.    ..|:|:||..:.: ..|....||...:|
Worm   322 LKQLLPNVNIVQGYGMTELTFATHLQSPGSPDG----SVGRLVPGTSMKV-KKEDGTLCGPHEIG 381

  Fly  1538 EIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTECSQSASLLDE-- 1600
            |:|::.|....||:                                    :.| .|:..||||
Worm   382 ELWIKGPQMMKGYW------------------------------------KKE-QQTNELLDEHG 409

  Fly  1601 --TTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAVDEV 1663
              .|..:...|.:.|:                                        ::...:.|:
Worm   410 FMRTGDIVYFDKNGET----------------------------------------FICDRIKEL 434

  Fly  1664 ISLRGMNYHPIDIENSVMRCHKKIAECAVF------TWTNLLVVVVELDGNESEALDLVPLVTNT 1722
            |.:......|.::|:.::. |..:|:..||      :....:..||...|.:.|....:....|.
Worm   435 IKVNAKQVAPAELESVILE-HDDVADVCVFGVDDASSGERPVACVVSKRGRDMETSKAIMKHINQ 498

  Fly  1723 VLEDHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFL 1760
            .|..::.|..:..|.:   :.....|:..|..::..||
Worm   499 KLARYKHIKEIEFVSE---IMRTGTGKLLRRAMKKAFL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	87/482 (18%)
		AFD_class_I	1159..1762	CDD:302604	111/646 (17%)
acs-7	NP_495979.1	CaiC	12..540	CDD:223395	117/674 (17%)
acs-7	NP_495979.1	Firefly_Luc_like	35..524	CDD:213279	109/640 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900