DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arnt2 and cyc

DIOPT Version :9

Sequence 1:	NP_036913.3	Gene:	Arnt2 / 25243	RGDID:	2154	Length:	712	Species:	Rattus norvegicus
Sequence 2:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	166/408 - (40%)
Similarity:	248/408 - (60%)	Gaps:	36/408 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat    51 DFDDEDGEGPSKFSR-ENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK 114
            ::|:|.....|..:| :||||||:|||:||..||.|||.|:|.|.|:.||.||||:|||||.|::
  Fly    17 NYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLR 81

  Rat   115 SMRGTGN----KSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQ 175
            .:||:|:    ..:|  |:||||::||||.:||:|::||||||..:.||::||||||:.|||..|
  Fly    82 GIRGSGSLHPFNGSD--YRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQ 144

  Rat   176 SEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFIC 239
            ::..|.:.::.:||.|:.|::|||.:.|.....|::|.||. .||.:..||..|:|.|:||||.|
  Fly   145 ADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFC 209

  Rat   240 RMRCGNA-------PLDHLPLNRITTMRK-RFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMSI 296
            ||:...|       ..|....:|.:|.|| |...|        .:|.|:.||||:|:|.|    |
  Fly   210 RMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTG--------HKYRVIQCTGYLKSWTP----I 262

  Rat   297 PEEDADVGQGSK----YCLVAIGRL--QVTSS--PVCMDMSGMSVPTEFLSRHNSDGIITFVDPR 353
            .:||.|.....:    .|||||||:  .|.:|  |..:|.........|:|||:.:|...|:|.|
  Fly   263 KDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQR 327

  Rat   354 CISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSF 418
            ...|||:.||::||....|:.|.||.:.|.||.:.|:::..:|.:.:||||.|:..::.:::...
  Fly   328 ATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWR 392

  Rat   419 TFQNPYSDEIEYVICTNT 436
            .|:||::.||:|:|..|:
  Fly   393 AFKNPWTSEIDYIIAKNS 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arnt2	NP_036913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		10/23 (43%)
		bHLH-PAS_ARNT	62..124	CDD:381517	36/66 (55%)
		PAS	137..243	CDD:395786	51/106 (48%)
		PAS_11	336..436	CDD:405306	36/99 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..712
cyc	NP_524168.2	HLH	31..84	CDD:278439	33/52 (63%)
		PAS	111..212	CDD:279347	47/100 (47%)
		PAS	111..173	CDD:214512	29/61 (48%)
		PAS_11	311..411	CDD:291273	37/100 (37%)
		PAS	311..406	CDD:238075	35/94 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820