DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyro3 and dpr10

DIOPT Version :9

Sequence 1:	NP_058788.1	Gene:	Tyro3 / 25232	RGDID:	3923	Length:	880	Species:	Rattus norvegicus
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	61/305 - (20%)
Similarity:	95/305 - (31%)	Gaps:	94/305 - (30%)

- Green bases have known domain annotations that are detailed below.

  Rat    39 PVKMTVSQGQPVKLNCSVEGMDDPDIHWMKD--------GAVVQNAS---QVSISISEQNWIGLL 92
            |..:|...|:...|.|.|:.:.:..:.|::.        |.......   |.|.......|  .|
  Fly    60 PRNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDIDEW--TL 122

  Rat    93 SLKSAERSDAGLYWCQVK-----------------DGEETKISQSVW------------------ 122
            .:|.|::.|||:|.||:.                 |.|.:.|.|..:
  Fly   123 QIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVYQSSND 187

  Rat   123 --------LTVEGVPFFTV-EPKDLAVPPNVPFQLSCEAVGPPEPVTIFWWRGPTKV------GG 172
                    :....||..|: ...||.|.......|:|.....|||.|..:|....||      ||
  Fly   188 EFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSGG 252

  Rat   173 --------PASSPSVLNV--TGVTQRTEFSCEAHN-------IKGLATSRPAIIRLQAPPAA--- 217
                    ...:.|:|.:  ..:....::||...|       :..|...||..::..|.|||
  Fly   253 RLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASIRVHVLQGERPEAMQTNAAPAAVAL 317

  Rat   218 -----PFNITVTTISSSNASVAWVPGADGLALLHSCTVQVAHAPG 257
                 .|......:...:..||      .|.||.:|:..:..:.|
  Fly   318 ACWSCHFGQATQAVRVISTMVA------ALVLLEACSSLLLQSGG 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyro3	NP_058788.1	IG_like	39..125	CDD:214653	24/139 (17%)
		IGc2	46..111	CDD:197706	18/92 (20%)
		Ig2_Tyro3_like	131..209	CDD:143226	23/101 (23%)
		IG_like	135..204	CDD:214653	20/91 (22%)
		FN3	215..307	CDD:238020	11/51 (22%)
		fn3	315..396	CDD:278470
		PTKc_Tyro3	498..781	CDD:270659
		Pkinase_Tyr	508..776	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..864
dpr10	NP_729591.1	Ig	63..143	CDD:299845	19/81 (23%)
		IG_like	210..297	CDD:214653	19/86 (22%)
		IGc2	217..287	CDD:197706	15/69 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910