DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyro3 and dpr3

DIOPT Version :9

Sequence 1:	NP_058788.1	Gene:	Tyro3 / 25232	RGDID:	3923	Length:	880	Species:	Rattus norvegicus
Sequence 2:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	64/296 - (21%)
Similarity:	109/296 - (36%)	Gaps:	70/296 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat    37 GAPVKMTVSQGQ-PVKLNCSVEGMDDPDIHWMKD--------GAVVQNAS---QVSISISEQNWI 89
            |.|..:|...|. ...:.|.|:.:.|..:.|::.        |.....:.   ||:.|...:.|
  Fly   241 GMPRNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREW- 304

  Rat    90 GLLSLKSAERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAV---PPNVPFQ---- 147
             .|.:|:....|:|:|.|||  ..|.|:|.:..|.:     ..:.|...||   ||::.|:
  Fly   305 -TLHVKAPLAKDSGIYECQV--NTEPKMSMAFQLNI-----IEISPDAKAVISGPPDLHFKAGSA 361

  Rat   148 --LSC-------EAVGPPEPVTIFWWRGPTKV-------GGPA---------------SSPSVLN 181
              |:|       :.:||     |:|:||...:       |.|.               :||:.:
  Fly   362 IILNCLVQQPSVKDIGP-----IYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDI- 420

  Rat   182 VTGVTQRTEFSCE---AHNIKGLATSRPAIIRLQAPPAAPFNITVTTISSSNASVAWVPGADGLA 243
            ::.|..:.||:..   ...:.....||..|...|......:....||.||::..|..:...:..|
  Fly   421 MSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTCQPTTASSASVLVHVINDENPAA 485

  Rat   244 LLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLA 279
            :..|.....|..|  .:.|..::.:|....|...||
  Fly   486 MQKSGACPCALGP--LQLLLHLLLLPELLLLRAGLA 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyro3	NP_058788.1	IG_like	39..125	CDD:214653	24/97 (25%)
		IGc2	46..111	CDD:197706	18/76 (24%)
		Ig2_Tyro3_like	131..209	CDD:143226	23/118 (19%)
		IG_like	135..204	CDD:214653	21/109 (19%)
		FN3	215..307	CDD:238020	14/65 (22%)
		fn3	315..396	CDD:278470
		PTKc_Tyro3	498..781	CDD:270659
		Pkinase_Tyr	508..776	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..864
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	22/90 (24%)
		IG_like	243..329	CDD:214653	21/89 (24%)
		Ig	350..464	CDD:299845	22/119 (18%)
		IG_like	<441..477	CDD:214653	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910