DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arsb and CG7402

DIOPT Version :9

Sequence 1:	NP_254278.1	Gene:	Arsb / 25227	RGDID:	2158	Length:	528	Species:	Rattus norvegicus
Sequence 2:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	206/556 - (37%)
Similarity:	300/556 - (53%)	Gaps:	64/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    22 LLLLL----LLWPARASDAAPPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYY 81
            :|:||    :|..|..|..:..|::|.:|.||:|.||:.|||| .|.||::||||..|::|:.:|
  Fly     6 ILVLLVVSSILSLAYGSGYSTKPNIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNGILLNKHY 70

  Rat    82 VQPLCTPSRSQLLTGRYQIHMGLQHYLIMTCQPNCVPLDEKLLPQLLKDAGYATHMVGKWHLGMY 146
            |..||||||:.||||:|.||.|:||::|:|.:|..:|..|:|:|::.:||||:||:|||||||.:
  Fly    71 VPNLCTPSRATLLTGKYPIHTGMQHFVIITDEPWGLPQRERLMPEIFRDAGYSTHLVGKWHLGFW 135

  Rat   147 RKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIECLNGTRCA-LDLRDGEEPAKEYTDIYSTNIF 210
            ||:..||.||||.:|||..|..|||.|:    :..|:....| ||.|...||..|....|:|..|
  Fly   136 RKDLTPTMRGFDHHFGYYNGYIDYYDHQ----VRMLDRNYSAGLDFRRDLEPCPEANGTYATEAF 196

  Rat   211 TKRATTLIANHPPEKPLFLYLAFQSVH-----DPLQVPEEYMEPYDFIQDKHRRIYAGMVSLLDE 270
            |..|..:|..|...||||:.|:..:||     .|:|.|||.:..:..|:|..||.||||:|.||:
  Fly   197 TSEAKRIIEQHDKSKPLFMVLSHLAVHTGNEDSPMQAPEEEVAKFPHIRDPKRRTYAGMISSLDK 261

  Rat   271 AVGNVTKALKSRGLWNNTVLIFSTDNGGQT----RSGGNNWPLRGRKGTLWEGGIRGAGFVASPL 331
            :|.....|||..|:.||::::..:|||..|    .:.|:|:|.||:|.:.||||||.||.:.|||
  Fly   262 SVAQTIGALKDNGMLNNSIILLYSDNGAPTIGIHSNAGSNYPYRGQKESPWEGGIRSAGALWSPL 326

  Rat   332 LKQKGVKSRELMHITDWLPTLVNLAGGSTHGTKPLDGFDVWETISEGSPSPRVELLLNIDPDFF- 395
            ||::|..|.:.:|..||||||...||.|.....||||.::|..:| |:..|:...::::..:.|
  Fly   327 LKERGYVSNQAIHAVDWLPTLAGAAGVSLPQDLPLDGINLWPMLS-GNEEPKPRTMIHVLDEVFG 390

  Rat   396 ------------DGLPCPGKNT----TPEKNDSFPLEHSAFNTSIHAGIRYKNWKLLTGYPG--- 441
                        :|....|:..    ..|.|:..||     ..|....:...:.:.|.|..|
  Fly   391 YSSYMRDTLKYVNGSSFKGRYDQWLGELETNEDDPL-----GESYEQHVLASDVQSLLGNRGLTK 450

  Rat   442 -------------CGYWFPPPSQSNISEVPSVDSPTKTLWLFDINRDPEERHDVSREHPHIVQNL 493
                         |    ||....|..|......|.|....||:.:||.||:::::.:|..:|.|
  Fly   451 DRIRQMRSEATETC----PPIEGQNPLESHFKCEPLKAPCFFDLAKDPCERYNLAQMYPLQLQQL 511

  Rat   494 LSRLQYYHEHSVPS-YFPPLDPRCDPK-GTGVWSPW 527
            ...|:...:.::|| ..|..|.|.:|. ..|.|..|
  Fly   512 ADELEQIRKTAIPSARVPHSDSRANPTFHNGNWEWW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arsb	NP_254278.1	AslA	36..484	CDD:225661	187/491 (38%)
Arsb	NP_254278.1	4-S	40..483	CDD:293753	187/486 (38%)
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	174/443 (39%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	171/417 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351145
Domainoid	1	1.000	308	1.000	Domainoid score	I1294
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H73870
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8957
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660