Protein Alignment FUS and NRP1

DIOPT Version :10

• Sequence 1: NP_004951.1
• Gene: FUS / 2521
• HGNCID: 4010
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_010114.1
• Gene: NRP1 / 851387
• SGDID: S000002326
• Length: 719
• Species: Saccharomyces cerevisiae
• Alignment Length: 630
• Identity: 105/630 - (16%)
• Similarity: 153/630 - (24%)
• Gaps: 278/630 - (44%)

Human     5 DYTQQATQS----YGAYP-------------TQPGQGYSQQSSQPY--GQQSYSGY------SQS 44
            |.||...:|    ||..|             :.....:|..:| ||  .|.|.||:      .::
Yeast   236 DTTQSELESWFTQYGVRPVGFWTVKNIVEDTSNVNNNWSLNNS-PYVEDQDSISGFVVFQTHEEA 299

Human    45 TDTSGY-GQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQ----- 103
            |:.... |:|..|:...::..............|||....:|...|.:.|..:.|..|..
Yeast   300 TEVLALNGRSILSNLANTKQPRVVEHVLELQPSSTGVLDKAQEILSPFPQSKNKPRPGDWNCPSC 364

Human   104 ----------------PAPSST------SGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQ 146
                            ||||::      |.:..:||:::...:..||| |...|.......||..
Yeast   365 GFSNFQRRTACFRCSFPAPSNSQIHTANSNNNVNSSRNNLNNRVNSGS-SSNISNTAANHPYGAP 428

Human   147 Q----SYNPPQG-------------YGQQNQYNSSSGGGGGG-------GGGGNYGQDQSSMSSG 187
            :    :.|.|..             ..:||..|.:....|..       .|..|...:....::.
Yeast   429 EFNMIANNTPAALTYNRAHFPAITPLSRQNSLNMAPSNSGSPIIIADHFSGNNNIAPNYRYNNNI 493

Human   188 GGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRG 252
            ..:.....|...                                 ||.:......|.|.|.|...
Yeast   494 NNNNNNINNMTN---------------------------------NRYNINNNINGNGNGNGNNS 525

Human   253 GMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKT 317
                             :..:.|::..:|:.:|                       |.|.:|..|
Yeast   526 -----------------NNNNNHNNNHNNNHHN-----------------------GSINSNSNT 550

Human   318 GQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNG 382
            ..                                                        |....||
Yeast   551 NN--------------------------------------------------------NNNNNNG 559

Human   383 RGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQC 447
            .........:|.||.|         ...|.         |||||||  .||...||:....|.:|
Yeast   560 NNSNNCNSNIGMGGCG---------SNMPF---------RAGDWKC--STCTYHNFAKNVVCLRC 604

Human   448 KAPKP------------DGPGGGP---------------GGSHMGGNYGDDRRG----------- 474
            ..||.            |....||               |||:.|...|:|.:|
Yeast   605 GGPKSISGDASETNHYIDSSTFGPASRTPSNNNISVNTNGGSNAGRTDGNDNKGRDISLMEFMSP 669

Human   475 ----GRGGYDRGGYRGRGGDRGGFRGGRGG------GDRGGFGPG 509
                .......|.  |.|.....|:..:..      ||...||.|
Yeast   670 PLSMATKSMKEGD--GNGSSFNEFKSDKANVNFSNVGDNSAFGNG 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..286		58/357 (16%)
		RRM_FUS_TAF15	283..368	CDD:409951	5/84 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..424		9/48 (19%)
		zf-RanBP	422..449	CDD:395516	13/26 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..526		23/114 (20%)
NRP1	NP_010114.1	RRM_ARP_like	226..328	CDD:409886	19/92 (21%)
		zf-RanBP	355..384	CDD:395516	3/28 (11%)
		RanBP2-type Zn finger	359..378	CDD:275376	0/18 (0%)
		zf-RanBP	581..609	CDD:395516	14/29 (48%)
		RanBP2-type Zn finger	585..604	CDD:275376	8/20 (40%)