DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FUS and Fus

DIOPT Version :9

Sequence 1:	NP_004951.1	Gene:	FUS / 2521	HGNCID:	4010	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_001012137.1	Gene:	Fus / 317385	RGDID:	1308864	Length:	518	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	501/529 - (94%)
Similarity:	504/529 - (95%)	Gaps:	14/529 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSY-SSYGQSQNT 64
            |||||||||||||||||||||||||||||:|||||||||||.||.|||||||||| |||||:|||
  Rat     1 MASNDYTQQATQSYGAYPTQPGQGYSQQSNQPYGQQSYSGYGQSADTSGYGQSSYGSSYGQTQNT 65

Human    65 GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGS 129
            ||||||.|||||||||||||||||||||||||||||||||||||||||||.|||||||||||||.
  Rat    66 GYGTQSAPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGGSSQSSSYGQPQSGG 130

Human   130 YSQQPSYGGQQQSYGQQQ-SYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGG 193
            |.||..|||||||||||| |||||||||||||||||| |||||||||||||||||| ||||.|||
  Rat   131 YGQQSGYGGQQQSYGQQQSSYNPPQGYGQQNQYNSSS-GGGGGGGGGNYGQDQSSM-SGGGGGGG 193

Human   194 YGNQDQSGGGGSG-GYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGS 257
            |||||||||||.| |.||||||||||        |||||||||||||||||||||||||||||||
  Rat   194 YGNQDQSGGGGGGYGGGQQDRGGRGR--------GGGGGYNRSSGGYEPRGRGGGRGGRGGMGGS 250

Human   258 DRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMI 322
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   251 DRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMI 315

Human   323 NLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRG 387
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   316 NLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRG 380

Human   388 RGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKP 452
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
  Rat   381 RGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRSECNQCKAPKP 445

Human   453 DGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEH 517
            ||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||
  Rat   446 DGPGGGPGGSHMGGNYGDDRR-GRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEH 509

Human   518 RQDRRERPY 526
            |||||||||
  Rat   510 RQDRRERPY 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..286		261/287 (91%)
		RRM_FUS_TAF15	283..368	CDD:240979	84/84 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..424		48/48 (100%)
		zf-RanBP	422..449	CDD:279035	25/26 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..526		80/81 (99%)
Fus	NP_001012137.1	RRM	<257..>367	CDD:223796	109/109 (100%)
		RRM_FUS_TAF15	276..361	CDD:240979	84/84 (100%)
		zf-RanBP	415..442	CDD:279035	25/26 (96%)
		RanBP2-type Zn finger	419..440	CDD:275376	19/20 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83694245
Domainoid	1	1.000	531	1.000	Domainoid score	I6282
eggNOG	1	0.900	-	-		E1_KOG1995
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I5105
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43140
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	1	1.000	-	-		oto130331
orthoMCL	1	0.900	-	-		OOG6_127496
Panther	1	1.100	-	-	LDO	PTHR23238
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.270