Protein Alignment Gucy1b2 and Gyc89Db

DIOPT Version :9

• Sequence 1: NP_001257640.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 742
• Species: Rattus norvegicus
• Sequence 2: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 198/729 - (27%)
• Similarity: 338/729 - (46%)
• Gaps: 150/729 - (20%)

  Rat     1 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQDV----FMTYTVYDDIITIKLIQEACKVLDV-- 59
            |||.:...:|..:.:::|.|||.|:   .::.|.    |.|:.:|.|    ||:.:....|..
  Fly     1 MYGMLYESVQHYIQQEYGMETWRKV---CQIVDCKHQSFKTHQIYPD----KLMPDFAAALSAST 58

  Rat    60 --SMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEE 122
              |.:..:..||..|.:|....|||:|:|:.|....:|::::|.:|..:..:|.:|.:||.::..
  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123

  Rat   123 -GADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQK 186
             ..|||::| |.|.|.|:...:.|.:..|||:|:..|:...:|:
  Fly   124 MDDDGAVIL-YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLE--------------------- 166

  Rat   187 AHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLR 251
            :...|.|..|...:.:|          |.|..:.:..|:.     :.....|.|.:|:
  Fly   167 SQNDICGGTAGPIKLTE----------GPLTVIVKYRLDF-----DNRDYMAKRVNVI------- 209

  Rat   252 DTFQPVYPERL---WVEEEVFCDAFPFHIVFDEALRVKQAGVNIQK----YVPGILTQKF----A 305
                 .:|.:|   .|:..||.:.|||.||.|..:::..||..|.:    :.||:..:.|    .
  Fly   210 -----AHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHI 269

  Rat   306 LDEY------------------------FSII---HPQVTFNISSICKFIN-------------- 329
            |:.:                        |.:|   |.:..::.:....|.|
  Fly   270 LERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMA 334

  Rat   330 ----SQFVLKTRKEMMPKARKSQP----------------MLKLRGQMIWMESLRCMIFMCSPKL 374
                .:|..:..||....|..|:.                .:.|:|||.:::.:..:||:|||.:
  Fly   335 LASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLI 399

  Rat   375 RSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIE-KKKTE 438
            .:|.||....::|:|:.||..:|:|::...|..:::|:..:.|:::.:....|..||.. |::.:
  Fly   400 ENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGD 464

  Rat   439 TLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTF-----TNICAACEPIQIVNMLNSMYS 498
            .|||:|:|..:|.::::..:.....||..:::|.:|:..     .||..|   :|.|..||.::|
  Fly   465 ELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDA---MQAVTTLNKVFS 526

  Rat   499 KFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRV 563
            ..|.......||||||:|..||.|.|.|.....||:...:.||  |:..|...:.:.|  :.|||
  Fly   527 ALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL--RVMKKVKAHALPG--VAIRV 587

  Rat   564 GIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIE 628
            ||::|||:|||||.|:||||||||||||||||||...|..:.||......::..|:::..||.::
  Fly   588 GINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVK 652

  Rat   629 VKGKGKMTTYFLIQ 642
            |||||:|.||:|::
  Fly   653 VKGKGEMETYWLLE 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	48/169 (28%)
		HNOBA	267..453	CDD:285003	56/255 (22%)
		CYCc	432..622	CDD:214485	75/195 (38%)
		Guanylate_cyc	459..642	CDD:278633	79/187 (42%)
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	48/166 (29%)
		HNOBA	218..479	CDD:400168	57/260 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	78/183 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780