DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh1 and Jheh2

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_611386.2	Gene:	Jheh2 / 37181	FlyBaseID:	FBgn0034405	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	251/459 - (54%)
Similarity:	319/459 - (69%)	Gaps:	8/459 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILVLILAIAGGLVYRNVTQLWADLPAPKLDPQEWWGDEAQPKDYEAYLKNNSEVIGNRLSYPDK 70
            :|||..|.|...:.|:|...|.|....|.||...:||    |...|.| :.|..::...:|...:
  Fly     7 RILVGALTILVAVGYKNYRDLSAPGKRPDLDNNAYWG----PTLKEPY-RENKAILPFDISVKPE 66

  Fly    71 TIADLKERLNRTLRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYLPRWREREVFLWQFNHFTTDI 135
            .|.||..:|:|.|:...|||||.|:||||.|.|.:||:||||.|||:|.|||.:|.:.:|:.|:|
  Fly    67 VIEDLIGQLSRPLKAQAPLEGVGFQYGFNANELAKVVKYWRDTYLPKWSEREEYLKKLDHYQTEI 131

  Fly   136 QGLRTHFLHLMVYD-DNKVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTNLDNNNKYIFNVVVPS 199
            |||:.||:|..... ..:..||..|:||:|||||:||||||||.||  |...:.:.|:|.|:.||
  Fly   132 QGLKIHFIHAKPSQVKGQKPKKVLPLLLMHGWPGTVREFYDFIPLL--TTPSDKSDYVFEVIAPS 194

  Fly   200 LPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENVLGYHSN 264
            |||||||||:|:.|.|.|||||:|||||||:|::||.:||||||||||||:|:|:||||||||||
  Fly   195 LPGYGWSQGSSKTGFGVAQVAVVMRNLMLRVGFDKFLVQGGDWGSIIGSNVASLFPENVLGYHSN 259

  Fly   265 MCNNLSPKSLAKGLVAEFWPSLFVPSGFEDFFFPKSNEMRYLMEESGYFHIQATKPDTIGAALTD 329
            ||.|.||....|.::|.|:||.||.|.:.||:....:....:|||.||.||||:||||||.||.|
  Fly   260 MCGNNSPMGQLKMVLASFFPSWFVDSEYADFYKGLGHLFSTIMEEMGYAHIQASKPDTIGNALID 324

  Fly   330 NPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNLMIYYLTNSITTSQRLYAEQYAQA 394
            ||.|||:|||||||||||.::|||||||||||:..|.||||:||||:|||||||.|||:|....:
  Fly   325 NPTGLASYILEKFSTWTNTAFRSLPDGGLTKRFTYDQLLDNVMIYYVTNSITTSMRLYSESMVAS 389

  Fly   395 QRDLHLDRVPTRVPTGCARFKSDIMQFLDVQLKDKYTNLVHSTYHKKGGHFAALEVPKVLYKDFI 459
            |..|.:|.||.:...||.||..:|..|.|..|.:|:.||||||:|:.||||.|.|:|:.||.||:
  Fly   390 QFALAVDSVPIKAKAGCTRFAHEITHFSDSVLANKFPNLVHSTHHRDGGHFPAFELPQQLYDDFV 454

  Fly   460 DFVE 463
            .||:
  Fly   455 SFVQ 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	50/104 (48%)
		MhpC	159..465	CDD:223669	189/305 (62%)
		Abhydrolase_5	159..>255	CDD:289465	65/95 (68%)
Jheh2	NP_611386.2	EHN	58..165	CDD:283978	50/106 (47%)
		Abhydrolase	111..>251	CDD:304388	83/141 (59%)
		Abhydrolase_1	156..370	CDD:278959	142/215 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457244
Domainoid	1	1.000	230	1.000	Domainoid score	I2378
eggNOG	1	0.900	-	-		E2759_KOG2565
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2516
Isobase	1	0.950	-	0	Normalized mean entropy	S2784
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		mtm6546
orthoMCL	1	0.900	-	-		OOG6_103115
Panther	1	1.100	-	-	P	PTHR21661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2361
SonicParanoid	1	1.000	-	-		X2023
	13	12.780