DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jheh1 and ephx5

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_021336553.1	Gene:	ephx5 / 322331	ZFINID:	ZDB-GENE-030131-1050	Length:	480	Species:	Danio rerio

Alignment Length:	490	Identity:	193/490 - (39%)
Similarity:	265/490 - (54%)	Gaps:	66/490 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILVLILAIAGG---LVYRNVTQLWADLPAPKLDP--QEWWGDEAQPKDYEAYLKNNSEVIGNRL 65
            |:.:|.|:.||.   |.|.:    |.  ..||..|  ..|||                  .|.:.
Zfish    25 KLQLLALSSAGVGALLCYLS----WR--KGPKTIPIGDGWWG------------------AGQKS 65

  Fly    66 SYPDKT------------IADLKERLNRTLRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYLPRW 118
            ...|||            |.||.:|::.| |.|.|||...|.||||:.||:.||.|||..:  .|
Zfish    66 LTEDKTIQRFVVKTSVEEIEDLHKRIDLT-RFTDPLEDSKFNYGFNSTYLRRVVSYWRHQF--NW 127

  Fly   119 REREVFLWQFNHFTTDIQGLRTHFLHLMVYDDNKVGKKHYPVLLLHGWPGSVREFYDFIHLLHQT 183
            .::...:.|:.||.|.|:|:..||:|  |....|.|:...|::::||||||..|||..|.||  |
Zfish   128 EKQVKVINQYPHFKTKIEGIDVHFVH--VRPLQKSGQTVVPLMMVHGWPGSFYEFYGIIPLL--T 188

  Fly   184 NLDNNNKYIFNVVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGS 248
            ..|:|  .:|.|:.||:||||:|:...:||....:.|.:...||.|||:::|::||||||:.|.|
Zfish   189 KTDSN--VVFEVICPSIPGYGYSEAPHKKGFNTMEAARIFLKLMERLGFSEFYVQGGDWGAFITS 251

  Fly   249 NIATLYPENVLGYHSNM--CNNLSPKSLAKGLVAEFWPSLFVPSGF--EDF--FFPKSNEMRY-L 306
            |:|.:.|:.|.|.|.||  ....|...|...::..:.|.|.   ||  ||.  .:|...:..| :
Zfish   252 NMAQMKPDCVRGLHLNMVIARTDSTAQLLSLVIGRYLPFLV---GFTKEDVRRLYPYMEKNIYDI 313

  Fly   307 MEESGYFHIQATKPDTIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNL 371
            :.|:||.|||||||||.|..|.|:|||||||||||||||||...|.|.||||.:::.:|.||.|:
Zfish   314 LRETGYLHIQATKPDTAGCGLNDSPVGLAAYILEKFSTWTNLENRDLEDGGLERKFNLDDLLTNV 378

  Fly   372 MIYYLTNSITTSQRLYAEQYAQAQRDL--HLDRVPT-RVPTGCARFKSDIMQFLDVQLKDKYTNL 433
            |||:.|.||..|.|.|.|   ..::|.  .:|||.: .||||.|.|..:::.........:::::
Zfish   379 MIYWTTCSIIPSMRFYKE---NLKKDFKTRVDRVTSIHVPTGLAAFPDELLHCPRAWASSRFSDV 440

  Fly   434 VHSTYHKKGGHFAALEVPKVLYKDFIDFVETVERK 468
            ...||..:||||||.|.|::|.:|.|.|.|.||.|
Zfish   441 RSFTYMPRGGHFAAFEEPQLLAQDIIQFAEKVEGK 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	42/115 (37%)
		MhpC	159..465	CDD:223669	137/315 (43%)
		Abhydrolase_5	159..>255	CDD:289465	44/95 (46%)
ephx5	XP_021336553.1	EHN	72..180	CDD:310799	42/112 (38%)
ephx5	XP_021336553.1	Abhydrolase_1	166..396	CDD:306935	111/236 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2378
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6546
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920