DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh1 and Ephx1

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001029262.1	Gene:	Ephx1 / 25315	RGDID:	2557	Length:	455	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	192/470 - (40%)
Similarity:	277/470 - (58%)	Gaps:	30/470 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLILA-IAGGLVYRNVTQLWADLPAPKLDPQE-------WWGDEAQPKDYEAYLKNNSEVIGNR 64
            |.|:|| :.|.::|..|::          |.:|       |||..::|.     .|.:..:...:
  Rat     3 LELVLASLLGFVIYWFVSR----------DKEETLPLGDGWWGPGSKPS-----AKEDESIRPFK 52

  Fly    65 LSYPDKTIADLKERLNRTLRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYLPRWREREVFLWQFN 129
            :...|:.|.||.:|::| .|.:|||||..|.||||:||:|:||.|||:::  .||::...|.|:.
  Rat    53 VETSDEEIKDLHQRIDR-FRASPPLEGSRFHYGFNSNYMKKVVSYWRNEF--DWRKQVEILNQYP 114

  Fly   130 HFTTDIQGLRTHFLHLMVYDDNKVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTNLDN-NNKYIF 193
            ||.|.|:||..||:|:.. .....|:...|:|::||||||..|||..|.||....... :::::|
  Rat   115 HFKTKIEGLDIHFIHVKP-PQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKSHGLSDEHVF 178

  Fly   194 NVVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENV 258
            .|:.||:||||:|:.:|:|||.....|.:...||.|||:.||:||||||||:|.:|:|.:.|.:|
  Rat   179 EVICPSIPGYGYSEASSKKGLNSVATARIFYKLMTRLGFQKFYIQGGDWGSLICTNMAQMVPNHV 243

  Fly   259 LGYHSNMC-NNLSPKSLAKGLVAEFWPSLFVPSGFEDFFFPKSNEMRY-LMEESGYFHIQATKPD 321
            .|.|.||. .:.|..::...|...|...|.......:..:|...::.| :|.||||.||||||||
  Rat   244 KGLHLNMAFISRSFYTMTPLLGQRFGRFLGYTEKDIELLYPYKEKVFYSIMRESGYLHIQATKPD 308

  Fly   322 TIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNLMIYYLTNSITTSQRL 386
            |:|.||.|:||||||||||||||||...||.|.||||.:::.:|.||.|:|||:.|.:|.:|||.
  Rat   309 TVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLDDLLVNIMIYWTTGTIVSSQRY 373

  Fly   387 YAEQYAQAQRDLHLDRVPTRVPTGCARFKSDIMQFLDVQLKDKYTNLVHSTYHKKGGHFAALEVP 451
            |.|...|.......:.:...||||.:.|.|:::...:..:|.||..|:..:|.::||||||.|.|
  Rat   374 YKENLGQGIMVHKHEGMKVFVPTGFSAFPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEP 438

  Fly   452 KVLYKDFIDFVETVE 466
            |:|.:|...||...|
  Rat   439 KLLAQDIRKFVSLAE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	44/103 (43%)
		MhpC	159..465	CDD:223669	138/308 (45%)
		Abhydrolase_5	159..>255	CDD:289465	46/96 (48%)
Ephx1	NP_001029262.1	EHN	48..157	CDD:399447	47/112 (42%)
Ephx1	NP_001029262.1	Abhydrolase_1	142..401	CDD:395444	118/258 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346087
Domainoid	1	1.000	239	1.000	Domainoid score	I2198
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2235
OMA	1	1.010	-	-		QHG63273
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		mtm8991
orthoMCL	1	0.900	-	-		OOG6_103115
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2023
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770