DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jheh1 and W01A11.1

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_504650.1	Gene:	W01A11.1 / 179036	WormBaseID:	WBGene00020909	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	182/486 - (37%)
Similarity:	267/486 - (54%)	Gaps:	60/486 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVTVKILVLILAIAGGLVYRNVTQLWADLPAPKLDPQE--WWGD-EAQPKDYEAYLKNNSEVIG 62
            ||:...|||   .:|.|::   ...:|..||..:::.:|  ::|. :|:|        :|:|:..
Worm     1 MGILKLILV---PVAIGVL---AAAVWNLLPEKEINVEENNYYGSGKAKP--------DNTEIKP 51

  Fly    63 NRLSYPDKTIADLKERLNRTLRLTPPL--EGVAFEYGFNTNYLKEVVEYWRDDYLPRWREREVFL 125
            .:::.....|.|||.|| :..|::..:  :...|.||||:..|.::.:||.:.|  .||::|..:
Worm    52 FKVNVEQSVIDDLKHRL-QNARISHSVLEDSDDFYYGFNSKQLLKLRDYWLNKY--DWRKQEATI 113

  Fly   126 WQFNHFTTDIQGLRTHFLHLMVYDDNKVGKKHYPVLLLHGWPGSVREFYDFIHLL---HQTNLDN 187
            .||..|.|:|:||:.||||:   ...|..|...|:|:.|||||:|.|||.||.||   .:..:|:
Worm   114 NQFPQFKTEIEGLQVHFLHV---KPPKSYKNVKPILVAHGWPGNVFEFYKFIPLLTDPKKHGIDS 175

  Fly   188 NNKYIFNVVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIAT 252
            :  :.|.|:.||:||||||....:.|......|.:.|.||||||||||::||||||:||.|.:..
Worm   176 D--FAFEVIAPSIPGYGWSDQPKKTGFSQLACARVFRKLMLRLGYNKFYLQGGDWGAIITSLLTK 238

  Fly   253 LYPENVLGYHSNMCNNLSPKSLAKGLVAEFWPSL--FVPSGFEDFFFPKS----NEMRYLMEESG 311
            :||:||:..|.||    .|.......:..|:..|  .:||........|:    ::...|:.|:|
Worm   239 VYPQNVMALHLNM----MPAMPGANALGTFYDILGWLIPSTLSSKEIQKTHNPFSKFGLLIVETG 299

  Fly   312 YFHIQATKPDTIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNLMIYYL 376
            |.|:|||||||.|.:|.|:|:||||||:||||||||...|:||||||.||:..|.||..:|||:.
Worm   300 YMHLQATKPDTAGTSLNDSPIGLAAYIIEKFSTWTNTENRALPDGGLNKRFTNDELLTIVMIYWT 364

  Fly   377 TNSITTSQRLYAEQYAQAQRDLHLDR---------VPTRVPTGCARFKSDIMQFLDVQLKDKYTN 432
            ..:|.:|||.|        |::.|||         |.|  ||..|...:::.....:::.....|
Worm   365 NGNIVSSQRFY--------REMFLDRRCEALGKRYVST--PTAHASGLNELYDRTPIEVSRHSYN 419

  Fly   433 LVHSTYHKKGGHFAALEVPKVLYKDFIDFVE 463
            :.|.| ....|||||.|.||.|.:....||:
Worm   420 ITHYT-EIDMGHFAAFEAPKPLAQSVFKFVK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	37/105 (35%)
		MhpC	159..465	CDD:223669	134/323 (41%)
		Abhydrolase_5	159..>255	CDD:289465	48/98 (49%)
W01A11.1	NP_504650.1	EHN	51..153	CDD:283978	37/107 (35%)
		MhpC	122..449	CDD:223669	142/346 (41%)
		Abhydrolase	126..>232	CDD:304388	52/110 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162517
Domainoid	1	1.000	223	1.000	Domainoid score	I1459
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I1529
Isobase	1	0.950	-	0	Normalized mean entropy	S2784
OMA	1	1.010	-	-		QHG63273
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		otm14366
orthoMCL	1	0.900	-	-		OOG6_103115
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2361
SonicParanoid	1	1.000	-	-		X2023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750