DRSC/TRiP Functional Genomics Resources

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Protein Alignment Jheh1 and Ephx2

DIOPT Version :9

Sequence 1:NP_611385.1 Gene:Jheh1 / 251984 FlyBaseID:FBgn0010053 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_031966.2 Gene:Ephx2 / 13850 MGIID:99500 Length:554 Species:Mus musculus


Alignment Length:383 Identity:74/383 - (19%)
Similarity:126/383 - (32%) Gaps:127/383 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 FTTDIQGLRTHFLHLMVYDDNKVGKKHYPVL-LLHGWPGSVREFYDFIHLLHQTNLDNNNKYIFN 194
            :.|...|:|.||:        ::|..  |.| |.||:|.|...:...|..|.|..        |.
Mouse   239 YVTVKPGIRLHFV--------EMGSG--PALCLCHGFPESWFSWRYQIPALAQAG--------FR 285

  Fly   195 VVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLML--------RLGYNKFFIQGGDWGSIIGSNIA 251
            |:...:.|||.|.       .|.::......|:.        :||..:....|.||..::..|:|
Mouse   286 VLAIDMKGYGDSS-------SPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMA 343

  Fly   252 TLYPENVLGYHSNMCN--------NLSPKSLAKGLVAEFWPSLFVPSG-------------FEDF 295
            ..|||.|....|  .|        ::||..:.:.:....:...|...|             |:.|
Mouse   344 LFYPERVRAVAS--LNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSF 406

  Fly   296 FFPKSNEMRYLMEESGYFHIQATKPDTIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTK 360
            |        ...:|:|:  |...|...||..|.:.|                      .|..|:|
Mouse   407 F--------RASDETGF--IAVHKATEIGGILVNTP----------------------EDPNLSK 439

  Fly   361 RYKMDALLDNLMIYYLTNSITTSQRL--YAEQYAQA--QRDLHLDRVPTR--------------V 407
                               |||.:.:  |.:|:.:.  :..|:..|...|              |
Mouse   440 -------------------ITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILV 485

  Fly   408 PTGCARFKSDIMQFLDVQLK-DKYTNLVHSTYHKKGGHFAALEVPKVLYKDFIDFVET 464
            |......:.||:...::... :|:...:...:.:..||:..:|.|..:.:..|.:::|
Mouse   486 PALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQT 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Jheh1NP_611385.1 EHN 64..168 CDD:283978 11/37 (30%)
MhpC 159..465 CDD:223669 68/355 (19%)
Abhydrolase_5 159..>255 CDD:289465 25/104 (24%)
Ephx2NP_031966.2 Phosphatase 1..224
HAD_sEH-N_like 3..214 CDD:319790
Phosphate binding. /evidence=ECO:0000250|UniProtKB:P34913 123..124
Epoxide hydrolase 233..554 74/383 (19%)
Abhydrolase_1 257..530 CDD:395444 65/340 (19%)
Microbody targeting signal. /evidence=ECO:0000255 552..554
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2361
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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