DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh1 and Ephx1

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_034275.1	Gene:	Ephx1 / 13849	MGIID:	95405	Length:	455	Species:	Mus musculus

Alignment Length:	472	Identity:	195/472 - (41%)
Similarity:	277/472 - (58%)	Gaps:	34/472 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLILA-IAGGLVYRNVTQLWADLPAPKLDPQE-------WWGDEAQPKDYEAYLKNNSEVIGNR 64
            |.|||| :.|.::|..|::          |.:|       |||..::|.     .|.:..:...:
Mouse     3 LELILASVLGFVIYWFVSR----------DKEETLPLEDGWWGPGSKPS-----AKEDESIRPFK 52

  Fly    65 LSYPDKTIADLKERLNRTLRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYLPRWREREVFLWQFN 129
            :...|:.|.||.:|::| .|.:|||||..|.||||::|||:||.:||:::  .||::...|.|:.
Mouse    53 VETSDEEIKDLHQRIDR-FRASPPLEGSRFHYGFNSSYLKKVVSFWRNEF--DWRKQVEILNQYP 114

  Fly   130 HFTTDIQGLRTHFLHLMVYDDNKVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTNLDN-NNKYIF 193
            ||.|.|:||..||:|:.. .....|:...|:|::||||||..|||..|.||....... :::::|
Mouse   115 HFKTKIEGLDIHFIHVKP-PQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKTHGLSDEHVF 178

  Fly   194 NVVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENV 258
            .|:.||:||||:|:.:|:|||.....|.:...||.|||:.||:||||||||:|.:|||.:.|.:|
Mouse   179 EVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGFQKFYIQGGDWGSLICTNIAQMVPNHV 243

  Fly   259 LGYHSNM---CNNLSPKSLAKGLVAEFWPSLFVPSGFEDFFFPKSNEMRY-LMEESGYFHIQATK 319
            .|.|.||   ..|:  .||...|...|...|.......:..:|...::.| :|.||||.||||||
Mouse   244 KGLHLNMSFISRNI--YSLTPLLGQRFGRFLGYTEKDLELLYPFKEKVFYNIMRESGYLHIQATK 306

  Fly   320 PDTIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNLMIYYLTNSITTSQ 384
            |||:|.||.|:||||||||||||||||...||.|.||||.:::.::.||.|:|||:.|.:|.:||
Mouse   307 PDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLEDLLTNIMIYWTTGTIVSSQ 371

  Fly   385 RLYAEQYAQAQRDLHLDRVPTRVPTGCARFKSDIMQFLDVQLKDKYTNLVHSTYHKKGGHFAALE 449
            |.|.|...|.......:.:...||||.:.|.|:|:...:..:|.||..|:..:|.::||||||.|
Mouse   372 RFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPEKWVKVKYPKLISYSYMERGGHFAAFE 436

  Fly   450 VPKVLYKDFIDFVETVE 466
            .||:|.:|...||...|
Mouse   437 EPKLLAQDIRKFVSLAE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	43/103 (42%)
		MhpC	159..465	CDD:223669	141/310 (45%)
		Abhydrolase_5	159..>255	CDD:289465	47/96 (49%)
Ephx1	NP_034275.1	EHN	50..152	CDD:283978	43/105 (41%)
		MhpC	121..448	CDD:223669	145/329 (44%)
		Abhydrolase	124..>255	CDD:304388	57/131 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842628
Domainoid	1	1.000	241	1.000	Domainoid score	I2235
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2307
Isobase	1	0.950	-	0	Normalized mean entropy	S2784
OMA	1	1.010	-	-		QHG63273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		otm42699
orthoMCL	1	0.900	-	-		OOG6_103115
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2361
SonicParanoid	1	1.000	-	-		X2023
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740