DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jheh1 and ephx1

DIOPT Version :9

Sequence 1:	NP_611385.1	Gene:	Jheh1 / 251984	FlyBaseID:	FBgn0010053	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001121449.1	Gene:	ephx1 / 100158543	XenbaseID:	XB-GENE-995306	Length:	457	Species:	Xenopus tropicalis

Alignment Length:	482	Identity:	187/482 - (38%)
Similarity:	273/482 - (56%)	Gaps:	50/482 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLILAIAGGLVYRNVTQLWADLPAPKLDPQE----WWGDEAQPKDYEAYLKNNSEVIGNRLSYP 68
            |:|.||: |.|:|..:.:       .|.:..|    |||...:|.:     :.:.|:...::...
Frog     5 LLLTLAV-GALLYHFIFK-------KKKETLEMGDGWWGPGVRPDN-----EGDEEIHPFKIETT 56

  Fly    69 DKTIADLKERLNRTLRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYLPRWREREVFLWQFNHFTT 133
            ::.:.||.:|::.| |.:.||||..|.||||:..|::||.|||:.:  .||::...|.:|.||.|
Frog    57 EEELKDLFDRIDHT-RYSEPLEGSRFNYGFNSTPLRKVVAYWRNTF--NWRKQLDILNKFPHFKT 118

  Fly   134 DIQGLRTHFLHLMVYDDNKV-----GKKHYPVLLLHGWPGSVREFYDFIHLLHQT---NLDNNNK 190
            .|:||..||:|:      |.     |:...|::::||||||..|||..|..|...   .||  .:
Frog   119 KIEGLDIHFIHV------KPPHLPGGRTAIPIIMVHGWPGSFYEFYKIIPFLTDPGSHGLD--TQ 175

  Fly   191 YIFNVVVPSLPGYGWSQGTSRKGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYP 255
            |||.|:.||:|||.:|:.:.::|.....||.:...||.|||:.:|:.|||||||:|.:|:|.:.|
Frog   176 YIFEVICPSIPGYSFSEASHKQGCESVAVARIFYKLMRRLGFREFYAQGGDWGSLICTNLAQIAP 240

  Fly   256 ENVLGYHSNMCNNLSPK--SLAKGLVAEFWPSLFVPSGFEDF-------FFPKSNEMRYLMEESG 311
            ..|.|.|.||......|  .:...::.:.:|.||   |..|.       ||.|  .:.::::|||
Frog   241 NQVKGLHINMAAAFPTKLPQILSVVLGQRFPGLF---GLHDEDVRRIFPFFKK--VVSHVIKESG 300

  Fly   312 YFHIQATKPDTIGAALTDNPVGLAAYILEKFSTWTNPSYRSLPDGGLTKRYKMDALLDNLMIYYL 376
            |.|:|||||||.|..|.::||||||||||||||||:|.:|...||||.:::.:|.||.|:|||:|
Frog   301 YMHLQATKPDTAGCGLNNSPVGLAAYILEKFSTWTDPDFRDHEDGGLERKFSLDDLLTNIMIYWL 365

  Fly   377 TNSITTSQRLYAEQYAQAQRDLHLDRVPTRVPTGCARFKSDIMQFLDVQLKDKYTNLVHSTYHKK 441
            :.||.:|.|.|.|...:.......|||...||||.|.|.::::.......|.||.|::...|..:
Frog   366 SGSIVSSMRFYKEVVGKGFGTAKHDRVQVTVPTGVASFPNELVHCPPFWAKQKYVNIISFNYMPR 430

  Fly   442 GGHFAALEVPKVLYKDFIDFVETVERK 468
            ||||||.|.|::|.||...||..||:|
Frog   431 GGHFAAFEEPELLAKDVQQFVGKVEQK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh1	NP_611385.1	EHN	64..168	CDD:283978	39/108 (36%)
		MhpC	159..465	CDD:223669	135/317 (43%)
		Abhydrolase_5	159..>255	CDD:289465	43/98 (44%)
ephx1	NP_001121449.1	EHN	50..152	CDD:283978	39/110 (35%)
		Abhydrolase	137..>231	CDD:304388	41/95 (43%)
		Abhydrolase_1	143..364	CDD:278959	100/227 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2384
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2515
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		mtm9414
Panther	1	1.100	-	-	O	PTHR21661
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150