DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp1 and Drice

DIOPT Version :9

Sequence 1:	NP_036894.3	Gene:	Casp1 / 25166	RGDID:	2274	Length:	402	Species:	Rattus norvegicus
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	85/326 - (26%)
Similarity:	139/326 - (42%)	Gaps:	52/326 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat    91 SGPSAETVFVTEDSKGGHPFSSETKEKLNKEGGAFPGPSGSLKFCPLEIAQKLWKENHSEIYPIM 155
            ||.:..:..|...|   ||:.|..   :.:....:..||.|.:    :...|:..:.|:..|. |
  Fly    35 SGGAGSSGLVAGSS---HPYGSGA---IGQLANGYSSPSSSYR----KNVAKMVTDRHAAEYN-M 88

  Rat   156 KTPTRTRLALIICNTDFQ--HLSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFA 218
            :...| .:|||..:..|:  .|..|.|.:||...:..:|:.|.:.|.|.::....::.:.: |:|
  Fly    89 RHKNR-GMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTI-EYA 151

  Rat   219 ACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQA 283
            |...|..||...:..:|||..    |..|:.:..  .|:|.|:.......||||..|||:..|||
  Fly   152 ASQNHSDSDCILVAILSHGEM----GYIYAKDTQ--YKLDNIWSFFTANHCPSLAGKPKLFFIQA 210

  Rat   284 CRGEK--QGVVLLKDSVGNSEEGFLTDAIFEDDGIK----KAHIEKDFIAFCSSTPDNVSWRHPV 342
            |:|::  .||.:.:...             |.||..    |..:..||:...|:.|...|||:..
  Fly   211 CQGDRLDGGVTMQRSQT-------------ETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTT 262

  Rat   343 QGSLFIESLIKHMKEYAWSCD----LEDIFRKVRFSFEQ--PDS-----RLQMP-TTERVTLTKR 395
            :||.|::||...:.......|    |..:.::|...||.  ||:     :.|:| .|..:|...|
  Fly   263 RGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILR 327

  Rat   396 F 396
            |
  Fly   328 F 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp1	NP_036894.3	CARD_CASP1-like	6..87	CDD:260036
Casp1	NP_036894.3	CASc	152..400	CDD:214521	73/265 (28%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	73/265 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910